1.
J Antibiot (Tokyo)
; 49(2): 124-8, 1996 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8621350
RESUMO
The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 1650I-759. The isolation was bioactivity-directed fractionation using an assay which measures the phosphatase activity of calcineurin. The compound was purified by countercurrent, reverse phase and gel filtration chromatographies. Several studies, including crystallographic, NMR and MS, revealed that dibefurin is a novel dimeric compound of a unique structural type.