RESUMO
OBJECTIVE: The aim of the study was the evaluation of risperidone effect on metabolite measures in the frontal lobe, temporal lobe and thalamus in schizophrenic patients on the basis of proton magnetic resonance spectroscopy ( (1)H MRS). METHODS: A group of 14 patients with the diagnosis of schizophrenia, according to DSM-IV, were examined in the study. The patients were examined twice, once after a period of at least 7 days without neuroleptics and for the second time at least 4 weeks after stable risperidone doses. RESULTS: The significant differences in the metabolite levels before and after the treatment were observed only in thalamus: an increase in myoinositol (mI) and N-acetylaspartate (NAA) levels. Positive symptoms before the treatment correlated positively with NAA level in the frontal lobes and negatively in the temporal lobes. Negative symptoms before the treatment correlated positively with Glx (a common signal for GABA, glutamine and glutamate) level in the temporal lobes. CONCLUSION: Our results seem to confirm the influence of risperidone on the brain metabolism, specifically in the region of thalamus.
Assuntos
Antipsicóticos/administração & dosagem , Metabolismo Energético/fisiologia , Espectroscopia de Ressonância Magnética , Risperidona/administração & dosagem , Esquizofrenia/diagnóstico , Lobo Temporal/efeitos dos fármacos , Tálamo/efeitos dos fármacos , Adulto , Ácido Aspártico/análogos & derivados , Ácido Aspártico/metabolismo , Colina/metabolismo , Creatina/metabolismo , Feminino , Lobo Frontal/efeitos dos fármacos , Lobo Frontal/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Prótons , Escalas de Graduação Psiquiátrica , Esquizofrenia/tratamento farmacológico , Estatística como Assunto , Lobo Temporal/metabolismo , Tálamo/metabolismoRESUMO
Presented patient was many times admitted to gynaecological wards and surgically treated with irreversible results. The complaints were mainly related to specific psychological disturbances.
Assuntos
Síndrome de Munchausen/diagnóstico , Adulto , Feminino , Humanos , Síndrome de Munchausen/psicologia , Convulsões/etiologiaRESUMO
The results of the insulin therapy of early schizophrenia patients in the Department of Psychiatry at the Medical Academy of Lublin are summarized in the article. The clinical data of 236 patients hospitalized in 1950-1983 was analysed with the use of standardized methods. The analysis showed that insulin therapy, is a relatively safe method of treatment. The antipsychotic effects of insulin therapy were substantial and comparable with the antipsychotic effectiveness of contemporary agents.