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1.
Eur J Clin Microbiol Infect Dis ; 33(10): 1835-41, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24848130

RESUMO

The purpose of this study was evaluation of the prevalence of co-infection with Borrelia species, A. phagocytophilum and Babesia spp. in patients with tick-borne encephalitis (TBE). At total of 110 patients with TBE were included in the study. Serological tests for tick-borne encephalitis virus (TBEV), PCR for Borrelia species, Anaplasma phagocytophilum and Babesia spp., blood smears for A. phagocytophilum and Babesia spp. and BLAST analysis for Babesia spp. were performed. Results showed a significant majority of patients co-infected with Borrelia species (30/110; 27 %), much less with A. phagocytophilum (12/110; 10.9 %) and with Babesia spp. (1/110; 0.9 %). The BLAST analysis of the 18S rDNA sequence obtained with the Babesia spp. specific primers indicated that the patient was infected with Babesia microti. Triple co-infections (TBEV-Borrelia species- A. phagocytophilum) were observed in three (3/110; 2.7 %) patients. Conclusions were such that differential diagnosis in patients after the tick bite, presenting with acute symptoms, should include not only TBE and Lyme disease, but also other diseases transmitted by ticks. In patients with low parasitemia in suspicion of Babesia spp. infection PCR seems to be a more sensitive method than blood smear. Co-infection with various tick-borne pathogens must be always considered, especially in endemic regions.


Assuntos
Babesiose/epidemiologia , Coinfecção/epidemiologia , Ehrlichiose/epidemiologia , Encefalite Transmitida por Carrapatos/complicações , Doença de Lyme/epidemiologia , Anaplasma phagocytophilum/isolamento & purificação , Babesia microti/isolamento & purificação , Borrelia/isolamento & purificação , DNA de Protozoário/química , DNA de Protozoário/genética , DNA Ribossômico/química , DNA Ribossômico/genética , Feminino , Humanos , Masculino , Prevalência , RNA Ribossômico 18S/genética , Análise de Sequência de DNA
2.
Rheumatol Int ; 32(10): 3189-91, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21960047

RESUMO

Recently, a possible etiological connection between infection with Borrelia burgdorferi and various skin lesions, including morphea and systemic sclerosis (SSc), has been discussed. The aim of our study was the evaluation of frequency of skin thickening typical of SSc or morphea in the group of patients with Lyme disease (LD) with frequent exposition to tick bites. The group consisted of 110 patients with LD frequently exposed to tick bites form the northeastern Poland, which is an endemic area for this disease. To measure the skin lesions, the modified Rodnan total skin score (RTSS) was used. In the analyzed group, no skin changes typical of morphea or skin thickening were found. According to RTSS, all patients scored 0 points. Raynaud's phenomenon in all patients was not found. The relationship between scleroderma or morphea and LD is still a matter of controversy. Described by some authors, cases with LD and scleroderma may be associated with co-existence of B. burgdorferi infection with autoimmune process.


Assuntos
Doença de Lyme/complicações , Esclerodermia Localizada/patologia , Escleroderma Sistêmico/patologia , Pele/patologia , Adulto , Idoso , Borrelia burgdorferi/imunologia , Feminino , Humanos , Doença de Lyme/imunologia , Doença de Lyme/microbiologia , Doença de Lyme/patologia , Masculino , Pessoa de Meia-Idade , Esclerodermia Localizada/imunologia , Esclerodermia Localizada/microbiologia , Escleroderma Sistêmico/imunologia , Escleroderma Sistêmico/microbiologia , Índice de Gravidade de Doença , Pele/imunologia , Pele/microbiologia
3.
Adv Med Sci ; 56(2): 311-7, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22008312

RESUMO

PURPOSE: The aim of the study was to assess the concentration of chemokines: CXCL10, XCL11, CXCL12, CXCL13 in serum and cerebrospinal fluid (CSF) in patients with tick-borne encephalitis (TBE) before and after treatment. We evaluated also the usefulness of these molecules in diagnosis and monitoring of inflammation in TBE. METHODS: Twenty three patients hospitalized in The Department of Infectious Diseases and Neuroinfections of Medical University in Bialystok, Poland were included in the study. Patients were divided into 2 groups: TBE group-patients with confirmed TBE and control group (CG): patients with excluded TBE and other inflammatory diseases of CNS. Concentration of CXCL10/IP-10, CXCL11/I-TAC, CXCL12/SDF-1α, CXCL13/BLC/BCA-1 in serum and CSF were measured with ELISA kits (R&D Systems, USA) according to the protocols. RESULTS: The analysis of chemokines concentration in TBE patients before treatment and control group using ROC showed that serum CXCL10 and CXCL13 and CSF CXCL10, CXCL11, CXCL12 and CXCL13 differentiate both groups (p<0.05). The analysis of CXCL10, CXCL11, CXCL12 and CXCL13 before and after treatment showed that CXCL10 and CXCL11 in CSF and CXCL13 in serum differentiates both groups with p<0.05. CONCLUSIONS: Concentration of CSF CXCL10, CXCL11, CXCL12, CXCL13 and serum CXCL10, CXCL13 may be good biomarkers of CNS inflammation caused by TBEV. Moreover concentration of CXCL10 in CSF and CXCL13 in serum may be used as indicators of patients recovery.


Assuntos
Quimiocina CXCL10/sangue , Quimiocina CXCL10/líquido cefalorraquidiano , Quimiocina CXCL11/sangue , Quimiocina CXCL11/líquido cefalorraquidiano , Quimiocina CXCL12/sangue , Quimiocina CXCL12/líquido cefalorraquidiano , Quimiocina CXCL13/sangue , Quimiocina CXCL13/líquido cefalorraquidiano , Encefalite Transmitida por Carrapatos/metabolismo , Regulação da Expressão Gênica , Adulto , Idoso , Biomarcadores , Sistema Nervoso Central/metabolismo , Encefalite Transmitida por Carrapatos/tratamento farmacológico , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Humanos , Inflamação , Masculino , Pessoa de Meia-Idade , Polônia , Sensibilidade e Especificidade
4.
Eur J Neurol ; 18(5): 673-9, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21143706

RESUMO

BACKGROUND AND PURPOSE: Tick-borne encephalitis (TBE) is an emerging disease in Europe as in Poland, especially in north-eastern part of the country. The aim of the study was to characterize the epidemiology and clinical features of TBE in this region. METHODS: Clinical and epidemiological data of 687 patients hospitalized between 1993 and 2008 at the Department of Infectious Diseases and Neuroinfections with the diagnosis of TBE were analysed. RESULTS: In the case of 59 patients (9.5%), the disease was job related (forestry workers, farmers). In the examined group, TBE presented with meningitis in 282 cases (41%), with meningoencephalitis in 353 cases (51.3%) and with meningoencephalomyelitis in 52 cases (7.6%). The most common neurological abnormalities were ataxia in 88 cases (14.17%) and pareses in 53 cases (8.53%). Four patients (0.6%) died, 144 patients (23.2%) were discharged with neurological sequelae of TBE. Two hundred and seventy-two patients (43.8%) required further psychiatric treatment. At least 38 patients (6.1%) developed long-term sequelae and required further hospitalizations. Dexamethasone in the dosage of 6-32 mg was administered in 407 patients for 1-64 days. CONCLUSIONS: The diagnosis of TBE sometimes is difficult as the disease symptoms may be non-characteristic. Therefore, a detailed anamnesis is very important in the process of TBE diagnosis and may alone justify lumbar puncture conduction. Despite usually mild course of the disease, patients may develop neurological and psychiatrical sequelae.


Assuntos
Encefalite Transmitida por Carrapatos/diagnóstico , Encefalite Transmitida por Carrapatos/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Comorbidade , Exposição Ambiental/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Exposição Ocupacional/efeitos adversos , Polônia/epidemiologia , Estudos Retrospectivos , Adulto Jovem
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