Effect of intermittent convection movements on voltammogram and current transients.

The influence of intermittent convection movements on electrochemical voltammograms is investigated. When the bath temperature rises to 315 K, the voltammograms exhibit irregular plateaus that differ for independent voltammetry scans, even when the setup is maintained under exactly the same conditions. In this paper, we show that such behavior can be caused by convection movements that develop in the electrolytic cell as a consequence of velocity fluctuations, since no bubbles or regular convective patterns are observed at this temperature. Theoretical current-potential curves for the heterogeneous deposition of metals on silicon electrodes is derived from a model consisting of a one-dimensional balance equation that includes diffusion, convection, and reaction through a time-dependent boundary condition. We obtain the current density associated with the adsorption of particles on the surface and, through this expression, we consider the effect of constant convective velocities on voltammograms. Finally, we examine the effect of random convective movements, described by a Monte Carlo algorithm that takes into account the random temporal fluctuations around a null convective current. The model predicts accentuated fluctuations on the current profiles, especially on the current plateaus that correspond to a stationary current regime. The validity of the theoretical model is checked against experimental data.

Chromosome 11 segmental paternal isodisomy in amniocytes from two fetuses with omphalocoele: new highlights on phenotype-genotype correlations in Beckwith-Wiedemann syndrome.

BACKGROUND: The phenotypic variability in Beckwith-Wiedemann syndrome (BWS) reflects the genetic heterogeneity of the mechanism which by default leads to the deregulation of genes located at 11p15.5. Genotype-phenotype correlation studies have demonstrated an association between omphalocoele and CDKN1C/p57 mutations or hypermethylation. Paternal uniparental disomy 11 (pUPD11) has been described only in the mosaic condition with both uniparental and biparental cell lines, and no association with omphalocoele has been pointed out. METHODS: Two cases are presented here, in which a paternal segmental UPD11 was detected by molecular investigation of amniotic fluid cell cultures after the presence of apparently isolated omphalocoele was revealed in the fetuses by ultrasound scan. Further studies were performed on additional autoptic feto-placental tissues to characterise the distribution of the uniparental cell line and to unmask any biparental lineage in order to document in more detail the as yet unreported association between omphalocoele and pUPD11. RESULTS: Results on the UPD distribution profile showed that the abdominal organs have a predominant uniparental constitution. This condition could mimic the effect of CDKN1C/p57 inactivation, causing the omphalocoele. CONCLUSION: New genotype-phenotype correlations emerge from the investigated cases, suggesting that molecular analysis be extended to all cases with fetal omphalocoele in order to establish the incidence of pUPD11 in complete BWS and in monosymptomatic/mild forms.

Fast and slow degrees of freedom coupling two different reservoirs.

We considered a Hamiltonian system that can be described by two generalized variables. One of them relaxes quickly when the system is in contact with a heat bath at fixed temperature, while the second one, the slow variable, mimics the interaction of the system with another heat bath at a lower temperature. The coupling between these variables leads to an energy flow between the heat baths. Allahverdyan and Nieuwenhuizen [Phys. Rev. E 62, 845 (2000)] proposed a formalism to deal with such problem and calculated the steady states of the system and some related properties as entropy production, energy dissipation, etc. In this work we applied the formalism to a coupled system of ideal gases and also to an ideal gas interacting with a harmonic oscillator. If the temperatures of the heat baths are not too close, the Onsager relations do not apply.