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OBJECTIVES: The objective of this investigation was to assess the impact of concurrent proton pump inhibitors (PPIs) on progression-free survival (PFS) in patients with hormone receptor-positive and HER2-negative metastatic breast cancer (mBC) who received palbociclib as first-line or successives therapy. MATERIALS AND METHODS: A retrospective observational study was conducted, enrolling patients diagnosed with estrogen receptor-positive, human epidermal growth factor receptor 2-negative mBC, and eligible for palbociclib treatment. Patients were categorized as "concurrent PPIs" if they received PPIs for at least two-thirds of the palbociclib therapy duration, and as "no concurrent PPIs" if they did not receive PPIs during the course of palbociclib treatment. RESULTS: A total of 165 patients were included in the study. Among first-line patients treated with palbociclib, those using concurrent PPIs exhibited a PFS of 8.88 months, while patients using palbociclib without concurrent PPIs had a PFS of 67.81 months (p < 0.0001). In second-line or subsequent treatments, patients on palbociclib with concurrent PPIs had a PFS of 7.46 months, whereas those using palbociclib without concurrent PPIs had a PFS of 17.29 months (p = 0.122). CONCLUSION: This study demonstrates that the concurrent use of PPIs in mBC patients receiving palbociclib negatively affects PFS, particularly in the first-line setting. Nevertheless, further investigation is warranted to explore the impact of PPIs on cycle-dependent kinase 4/6 inhibitors.
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BACKGROUND: In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe. METHODS: Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000-2020. RESULTS: A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P = .013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P < .001; odds ratio [95% confidence interval], 2.073 [1.37-3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P < .001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P < .001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P = .083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P = .004). CONCLUSIONS: Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies.
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Hospedeiro Imunocomprometido , Tuberculose , Humanos , Estudos de Casos e Controles , Criança , Masculino , Feminino , Adolescente , Europa (Continente)/epidemiologia , Tuberculose/epidemiologia , Tuberculose/diagnóstico , Pré-Escolar , Lactente , Teste Tuberculínico , Antituberculosos/uso terapêuticoRESUMO
BACKGROUND: Rheumatic and musculoskeletal diseases (RMDs) are chronic diseases that may alternate between asymptomatic periods and flares. These conditions require complex treatments and close monitoring by rheumatologists to mitigate their effects and improve the patient's quality of life. Often, delays in outpatient consultations or the patient's difficulties in keeping appointments make such close follow-up challenging. For this reason, it is very important to have open communication between patients and health professionals. In this context, implementing telemonitoring in the field of rheumatology has great potential, as it can facilitate the close monitoring of patients with RMDs. The use of these tools helps patients self-manage certain aspects of their disease. This could result in fewer visits to emergency departments and consultations, as well as enable better therapeutic compliance and identification of issues that would otherwise go unnoticed. OBJECTIVE: The main objective of this study is to evaluate the implementation of a hybrid care model called the mixed attention model (MAM) in clinical practice and determine whether its implementation improves clinical outcomes compared to conventional follow-up. METHODS: This is a multicenter prospective observational study involving 360 patients with rheumatoid arthritis (RA) and spondylarthritis (SpA) from 5 Spanish hospitals. The patients will be followed up by the MAM protocol, which is a care model that incorporates a digital tool consisting of a mobile app that patients can use at home and professionals can review asynchronously to detect incidents and follow patients' clinical evolution between face-to-face visits. Another group of patients, whose follow-up will be conducted in accordance with a traditional face-to-face care model, will be assessed as the control group. Sociodemographic characteristics, treatments, laboratory parameters, assessment of tender and swollen joints, visual analog scale for pain, and electronic patient-reported outcome (ePRO) reports will be collected for all participants. In the MAM group, these items will be self-assessed via both the mobile app and during face-to-face visits with the rheumatologist, who will do the same for patients included in the traditional care model. The patients will be able to report any incidence related to their disease or treatment through the mobile app. RESULTS: Participant recruitment began in March 2024 and will continue until December 2024. The follow-up period will be extended by 12 months for all patients. Data collection and analysis are scheduled for completion in December 2025. CONCLUSIONS: This paper aims to provide a detailed description of the development and implementation of a digital solution, specifically an MAM. The goal is to achieve significant economic and psychosocial impact within our health care system by enhancing control over RMDs. TRIAL REGISTRATION: ClinicalTrials.gov NCT06273306; https://clinicaltrials.gov/ct2/show/NCT06273306. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/55829.
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Telemedicina , Humanos , Telemedicina/métodos , Estudos Prospectivos , Artrite Reumatoide/imunologia , Artrite Reumatoide/terapia , Espanha , Masculino , FemininoRESUMO
Objetivo: El objetivo de este estudio fue analizar la relación entre el colesterol-HDL y el riesgo de infección por SARS-CoV-2 en mayores de 75 años residentes en la Comunidad de Madrid. Métodos: Estudio de una cohorte de base poblacional, compuesto por todos los residentes en Madrid (España) nacidos antes del 1 de enero de 1945 y vivos el 31 de diciembre de 2019. Los datos demográficos, clínicos y analíticos se obtuvieron de las historias clínicas electrónicas de atención primaria desde enero de 2015. La infección confirmada por SARS-CoV-2 se definió como un resultado positivo en la RT-PCR o en la prueba de antígeno. Los datos sobre infección por SARS-CoV-2 corresponden al periodo del 1 de marzo de 2020 hasta el 31 de diciembre de 2020. Resultados: De los 593.342 participantes de la cohorte, 501.813 tenían al menos una determinación de colesterol-HDL en los últimos 5 años. Su edad media era 83,4±5,6 años y el 62,4% eran mujeres. Un total de 36.996 (7,4%) tuvieron una infección confirmada por SARS-CoV2 durante el año 2020. El riesgo de infección (odds ratio [intervalo de confianza 95%]) por SARS-CoV2 según los quintiles crecientes de colesterol-HDL fue de 1; 0,960 (0,915-1,007), 0,891 (0,848-0,935), 0,865 (0,824-0,909) y 0,833 (0.792-0,876), tras ajustar por edad, sexo, factores de riesgo cardiovascular y comorbilidades. Conclusiones: Existe una relación inversa y dosis-dependiente entre la concentración de colesterol-HDL y el riesgo de infección por SARS-CoV2 en los mayores de 75 años de la Comunidad de Madrid. (AU)
Objective: The aim of this study was to analyze the relationship between HDL-cholesterol and the risk of SARS-CoV-2 infection in over 75-year-olds residing in the Community of Madrid. Methods: Study of a population-based cohort, composed of all residents in Madrid (Spain) born before January 1, 1945 and alive on December 31, 2019. Demographic, clinical and analytical data were obtained from primary care electronic medical records from January 2015. Confirmed SARS-CoV-2 infection was defined as a positive RT-PCR or antigen test result. Infection data correspond to the period March 1, 2020 through December 31, 2020. Results: Of the 593,342 cohort participants, 501,813 had at least one HDL-cholesterol determination in the past 5 years. Their mean age was 83.4±5.6 years and 62.4% were women. A total of 36,996 (7.4%) had a confirmed SARS-CoV2 infection during 2020. The risk of infection [odds ratio (95% confidence interval)] for SARS-CoV2 according to increasing quintiles of HDL-cholesterol was 1, 0.960 (0.915-1.007), 0.891 (0.848-0.935), 0.865 (0.824-0.909) and 0.833 (0.792-0.876), after adjusting for age, sex, cardiovascular risk factors and comorbidities. Conclusions: There is an inverse and dose-dependent relationship between HDL-cholesterol concentration and the risk of SARS-CoV2 infection in subjects aged over 75 years of age in the Community of Madrid. (AU)
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Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Pandemias , Infecções por Coronavirus/epidemiologia , HDL-Colesterol , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave , Fatores de Risco , RNA ViralRESUMO
Introduction: This study aimed to evaluate whether early vitamin C and thiamine administration was associated with a lower 28-day and in-hospital mortality in surgical critically ill patients with refractory septic shock. Patients and methods: We performed a retrospective before-and-after study on patients with refractory septic shock. According to local protocol, hydrocortisone is initiated in case of refractory septic shock. In January 2017, the protocol was changed and vitamin C and thiamine were included. Patients who were admitted in 2015-2016 and 2017-2018 were included in the control and treatment groups, respectively. The primary end point was 28-day and in-hospital mortality. Secondary end points were ICU mortality, ICU and hospital length of stay, duration of vasopressors and mechanical ventilation, use of renal replacement therapy (RRT), and the modification in serum procalcitonin and SOFA score during the first 72 h. Results: A total of 120 patients were included (58 in the treatment group and 62 in the control group). Log-rank test in Kaplan-Meier curves showed lower 28-day and in-hospital mortality over time in the treatment group (p=0.021 and p=0.035, respectively) but it not reached statistical significance in ICU mortality over time (p=0.100). The need of RRT was less frequent in treatment group (17.2% vs. 37.1%, p=0.024). There were no differences in other secondary outcomes. Conclusions: Intravenous vitamin C and thiamine administration in surgical patients with refractory septic shock may be associated with a lower 28-day and in-hospital mortality. Further prospective studies are needed in refractory septic shock. (AU)
Introducción: El objetivo de este estudio fue evaluar si la administración precoz de vitamina C y tiamina estaba asociada a una reducción en la mortalidad a los 28 días y hospitalaria en pacientes críticos quirúrgicos con shock séptico refractario. Pacientes y métodos: Realizamos un estudio retrospectivo antes-después en pacientes con shock séptico refractario. Según el protocolo local, se inicia tratamiento con hidrocortisona en situación de shock séptico refractario. En enero de 2017 se cambió el protocolo y se incluyó vitamina C y tiamina. Los pacientes que fueron ingresados en 2015-2016 y 2017-2018 se incluyeron en el grupo control y tratamiento, respectivamente. Los objetivos primarios fueron la mortalidad a los 28 días y hospitalaria. Los objetivos secundarios fueron la mortalidad en UCI, la duración de estancia en UCI y hospitalaria, la duración del tratamiento vasopresor y de la ventilación mecánica, el uso de técnicas de reemplazo renal (TRR), y la modificación en la procalcitonina sérica y la puntuación SOFA durante las primeras 72h. Resultados: Se incluyeron un total de 120 pacientes (58 en el grupo tratamiento y 62 en el grupo control). El test Log-rank en las curvas de Kaplan-Meier mostró mortalidad a los 28 días y hospitalaria más baja a lo largo del tiempo en el grupo tratamiento (p=0,021 and p=0,035, respectivamente) pero no alcanzó significación estadística en la mortalidad en UCI a lo largo del tiempo (p=0,100). La necesidad de TRR fue menos frecuente en el grupo tratamiento (17,2% vs. 37,1%, p=0,024). No hubo diferencias en otros resultados secundarios. Conclusiones: La administración de vitamina C y tiamina intravenosa en pacientes quirúrgicos con shock séptico refractario podría estar asociada a una menor mortalidad a los 28 días y hospitalaria. Se necesitan más estudios prospectivos en pacientes con shock séptico refractario. (AU)
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Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Vitamina D/uso terapêutico , Tiamina/uso terapêutico , Choque Séptico/tratamento farmacológico , Estudos Retrospectivos , VasoconstritoresRESUMO
Introduction: Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF). Aim: This study aimed to investigate the effects of air pollution on clinical worsening, lung function, and radiological deterioration in patients with IPF. Methods: This exploratory retrospective cohort study included 69 patients with IPF, monitored from 2011 to 2020. Data on air pollution levels, including carbon monoxide (CO), nitrogen dioxide (NO2), particulate matter ≤ 2.5 µM (PM2.5), ozone (O3), and nitrogen oxides (NOx), were collected from the nearest air quality monitoring stations (<3.5 km from the patients' homes). Patient outcomes such as clinical worsening, lung function decline, and radiological deterioration were assessed over various exposure periods (1, 3, 6, 12, and 36 months). The statistical analyses were adjusted for various factors, including age, sex, smoking status, and treatment. Results: There was an association between higher O3 levels and an increased likelihood of clinical worsening over 6 and 36 months of exposure (odds ratio [OR] and 95% confidence interval [CI] = 1.16 [1.01-1.33] and OR and 95% CI = 1.80 [1.07-3.01], respectively). Increased CO levels were linked to lung function decline over 12-month exposure periods (OR and 95% CI 1.63 = [1.01-2.63]). Lastly, radiological deterioration was significantly associated with higher CO, NO2, and NOx levels over 6-month exposure periods (OR and 95% CI = 2.14 [1.33-3.44], OR and 95% CI = 1.76 [1.15-2.66] and OR and 95% CI = 1.16 [1.03-1.3], respectively). Conclusion: This study suggests that air pollution, specifically O3, CO, NO2, and NOx, could affect clinical worsening, lung function, and radiological outcomes in patients with IPF. These findings highlight the potential role of air pollution in the progression of IPF, emphasizing the need for further research and air quality control measures to mitigate its effects on respiratory health.
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Poluição do Ar , Fibrose Pulmonar Idiopática , Humanos , Dióxido de Nitrogênio/efeitos adversos , Estudos Retrospectivos , Poluição do Ar/efeitos adversos , Pulmão/diagnóstico por imagemRESUMO
Objetivo: El objetivo de este estudio fue analizar la relación entre el colesterol-HDL y el riesgo de infección por SARS-CoV-2 en mayores de 75 años residentes en la Comunidad de Madrid. Métodos: Estudio de una cohorte de base poblacional, compuesto por todos los residentes en Madrid (España) nacidos antes del 1 de enero de 1945 y vivos el 31 de diciembre de 2019. Los datos demográficos, clínicos y analíticos se obtuvieron de las historias clínicas electrónicas de atención primaria desde enero de 2015. La infección confirmada por SARS-CoV-2 se definió como un resultado positivo en la RT-PCR o en la prueba de antígeno. Los datos sobre infección por SARS-CoV-2 corresponden al periodo del 1 de marzo de 2020 hasta el 31 de diciembre de 2020. Resultados: De los 593.342 participantes de la cohorte, 501.813 tenían al menos una determinación de colesterol-HDL en los últimos 5 años. Su edad media era 83,4±5,6 años y el 62,4% eran mujeres. Un total de 36.996 (7,4%) tuvieron una infección confirmada por SARS-CoV2 durante el año 2020. El riesgo de infección (odds ratio [intervalo de confianza 95%]) por SARS-CoV2 según los quintiles crecientes de colesterol-HDL fue de 1; 0,960 (0,915-1,007), 0,891 (0,848-0,935), 0,865 (0,824-0,909) y 0,833 (0.792-0,876), tras ajustar por edad, sexo, factores de riesgo cardiovascular y comorbilidades. Conclusiones: Existe una relación inversa y dosis-dependiente entre la concentración de colesterol-HDL y el riesgo de infección por SARS-CoV2 en los mayores de 75 años de la Comunidad de Madrid. (AU)
Objective: The aim of this study was to analyze the relationship between HDL-cholesterol and the risk of SARS-CoV-2 infection in over 75-year-olds residing in the Community of Madrid. Methods: Study of a population-based cohort, composed of all residents in Madrid (Spain) born before January 1, 1945 and alive on December 31, 2019. Demographic, clinical and analytical data were obtained from primary care electronic medical records from January 2015. Confirmed SARS-CoV-2 infection was defined as a positive RT-PCR or antigen test result. Infection data correspond to the period March 1, 2020 through December 31, 2020. Results: Of the 593,342 cohort participants, 501,813 had at least one HDL-cholesterol determination in the past 5 years. Their mean age was 83.4±5.6 years and 62.4% were women. A total of 36,996 (7.4%) had a confirmed SARS-CoV2 infection during 2020. The risk of infection [odds ratio (95% confidence interval)] for SARS-CoV2 according to increasing quintiles of HDL-cholesterol was 1, 0.960 (0.915-1.007), 0.891 (0.848-0.935), 0.865 (0.824-0.909) and 0.833 (0.792-0.876), after adjusting for age, sex, cardiovascular risk factors and comorbidities. Conclusions: There is an inverse and dose-dependent relationship between HDL-cholesterol concentration and the risk of SARS-CoV2 infection in subjects aged over 75 years of age in the Community of Madrid. (AU)
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Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Infecções por Coronavirus/epidemiologia , HDL-Colesterol , RNA Viral , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave , Espanha , PandemiasRESUMO
IntroducciónEn 2017 se realizó una encuesta a nivel mundial sobre el cumplimiento de las prácticas que promueve la Neo-IHAN (Iniciativa para la Humanización de la Asistencia al Nacimiento y la Lactancia en las unidades neonatales).Objetivo: Presentar los resultados de las unidades españolas que participaron en la encuesta mundial y compararlos con los obtenidos internacionalmente.Material y métodos: Estudio transversal mediante una encuesta sobre el cumplimiento de los requisitos de la Neo-IHAN («Tres principios básicos», «Diez pasos adaptados a unidades neonatales» y el «cumplimiento del Código internacional de comercialización de sucedáneos de leche materna»). El cumplimiento se calculó como la media en cada indicador y una puntuación media final para cada unidad neonatal. Para las puntuaciones parciales y finales de cada país y a nivel internacional se utilizó la mediana. Las puntuaciones van de 0 a 100.Resultados: La tasa de respuesta en España fue del 90% de las unidades de nivel 2 y 3. El rango de la media para las unidades neonatales fue de 37 a 99, sin diferencias según el nivel asistencial. La puntuación global de España (72) está por debajo de la mediana internacional (77), así como en 8 de los 14 requisitos de la Neo-IHAN. Las unidades neonatales de hospitales con maternidades acreditadas IHAN obtuvieron una puntuación media final significativamente mayor, así como en 9 de los 14 requisitos frente a las no acreditadas.Conclusiones: Los resultados, tanto internacionales como nacionales, indican una mejora de las prácticas de la lactancia materna en las unidades neonatales. Los beneficios de la acreditación IHAN de las maternidades alcanzan a las unidades neonatales. España tiene varios puntos clave por debajo de la puntuación internacional. (AU)
Introduction: In 2017, a worldwide survey was conducted on compliance with the practices promoted by Neo-BFHI (Baby-friendly Hospital Initiative expansion to neonatal wards).Objective: Present the results of the Spanish wards that participated in the global survey and compare them with those obtained internationally.Material and methods: Cross-sectional study through a survey on compliance with the Neo-BFHI (Three basic principles, Ten steps adapted to neonatal wards and the compliance with the International Code of Marketing of Breast-milk Substitutes and subsequent relevant World Health Assembly resolutions). Compliance was calculated as the mean in each indicator and a final mean score for each neonatal unit. For the partial and final scores for each country and at the international level, the median was used. All score ranged between 0 and 100.Results: The response rate in Spain was 90%. The range of the national mean for neonatal wards were from 37 to 99, with no differences in the final score according to the level of care. The global score for Spain (72) is below the international median (77) and this also occurs in 8 of 14 items. The neonatal wards from BFHI designated hospitals, obtained a significantly higher mean global score, and in 9 of 14 items than the non-accredited ones.Conclusions: Both international and national results indicate an improvement in breastfeeding practices in neonatal units. The benefits of the BFHI accreditation of maternity reach neonatal wards. Spain has several key points below the international score. (AU)
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Humanos , Aleitamento Materno/métodos , Aleitamento Materno/estatística & dados numéricos , Aleitamento Materno/tendências , Estudos Transversais , Inquéritos e Questionários , EspanhaRESUMO
Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial y en España. El objetivo de este estudio fue evaluar los FRCV clásicos modificables en una muestra de trabajadores del Hospital Universitario La Paz (HULP) con relación a la categoría profesional, edad, sexo, así como estimar el riesgo cardiovascular según el modelo SCORE para los trabajadores ≥ 40 años y con el Riesgo Relativo (RR) en menores de 40 años. MATERIAL Y MÉTODOS: Se realizó un estudio observacional descriptivo retrospectivo con un análisis de variables de FRCV en una muestra de 687 trabajadores del HULP de Madrid durante 2016. Se recogieron variables clínicas, antropométricas y sociodemográficas. Para el análisis comparativo, se aplicó la prueba de Chi-cuadrado de Pearson o el test exacto de Fisher para las variables cualitativas, mientras que la prueba de Kruskal-Wallis se usó para determinar la asociación entre variables cuantitativas y cualitativas. El riesgo cardiovascular se determinó mediante el baremo SCORE y el RR. RESULTADOS: La muestra fue de 687 trabajadores (70,8% mujeres, y 29,2% hombres). La prevalencia de tabaquismo fue del 21%, no fumadores (60%) y exfumadores (19%). Dislipemia: 58,8%. Hipertensión arterial: 24,3%. Inactividad física: 35,7%, con 3,8 ± 2 horas semanales de ejercicio físico. Obesidad/sobrepeso: 36,5%. DM: 4,5%. Alcohol: 37,8%. En el cálculo del riesgo cardiovascular se encontró un SCORE alto/muy alto: 15,2% y RR = 1 (83%), RR = 2 (16%) y RR = 3 (1%). CONCLUSIONES: Se halló una elevada prevalencia de FRCV en los sujetos que acuden a realizarse el examen de salud, similar a la hallada en otros estudios consultados con poblaciones laborales y no laborales. Se encontró mayor prevalencia de factores de riesgo modificables en personal de gestión y servicios y en técnicos sanitarios que en diplomados y licenciados sanitarios. Y conforme al aumento de edad y en el sexo masculino
OBJECTIVE: Cardiovascular diseases are the first cause of death worldwide and in Spain. The objective of this study was to research the classic cardiovascular risk factors (CVRF) in a population in Madrid Hospital La Paz by professional category, age and gender as well as to estimate the cardiovascular risk using the SCORE model for workers ≥ 40 years and with Relative Risk (RR) for under 40 years. MATERIAL AND METHODS: A descriptive observational retrospective study was carried out with a CVRF variables analysis in a 687 workers population at the Madrid HULP in 2016. Clinical, anthropometric, and sociodemographic variables were gathered. For the comparative analysis, Pearson's Chi-squared or Fisher exact test were applied for the qualitative variables, and Kruskal-Wallis was used to determine the association between qualitative and quantitative variables. Cardiovascular risk was determined by SCORE and RR. RESULTS: The sample was 687 workers (70,8% women and 29,2% men). Smoking prevalence was 21%, non-smoking (60%) and former smokers (19%). Dyslipidaemia: 58,8%. Arterial hypertension: 24,3%. Physical inactivity: 35,7%, with 3,8 ± 2 hours/week of physical exercise. Obesity/overweigh:36,5%. DM: 4,5%. Alcohol: 37,8%. Cardiovascular risk calculation was determined by SCORE high/very high: 15,2% and RR = 1 (83%), RR = 2 (16%) and RR = 3 (1%). CONCLUSIONS: A high CVRF prevalence was found in the subjects that came to the health surveillance screening, similar at the one in occupational and non-occupational studies that has been consulted. A higher prevalence of modifiable risk factors was found in management and services personnel and in medical technicians than in healthcare university graduates. And more as the age increases and in male gender
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Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Doenças Profissionais/etiologia , Doenças Cardiovasculares/etiologia , Hospitais Universitários/estatística & dados numéricos , Estudos Retrospectivos , Doenças Profissionais/epidemiologia , Doenças Cardiovasculares/epidemiologia , Fatores de Risco , Medição de Risco , Distribuição por Idade e Sexo , Fumar/efeitos adversos , Fumar/epidemiologia , Dislipidemias/complicações , Dislipidemias/epidemiologia , Hipertensão/complicações , Hipertensão/epidemiologia , Obesidade/complicações , Obesidade/epidemiologia , Prevalência , Espanha/epidemiologiaRESUMO
OBJETIVOS: La enfermedad cardiovascular es consecuencia en muchos casos de hábitos poco saludables, y la promoción de la salud en el trabajo incluye la realización de una serie de políticas y actividades diseñadas para ayudar a trabajadores a aumentar el control sobre su salud y a mejorarla. El objetivo de este estudio fue evaluar las estrategias de promoción de la salud cardiovascular realizadas en hospitales públicos de la Comunidad de Madrid para poder implementar en un futuro mejoras en las áreas más deficientes. Material y MÉTODOS: Se realizó un estudio observacional descriptivo prospectivo mediante una encuesta vía email a 10 hospitales públicos de la Comunidad de Madrid. Se utilizó el cuestionario Move Europe facilitado por el INSST. La descripción de las variables cualitativas se realizó con la frecuencia absoluta y porcentajes. RESULTADOS: La tasa de respuesta de los centros en la encuesta fue del 100%. Se encontró un muy bajo porcentaje de hospitales que alcanzasen la puntuación de "buenas prácticas" en las diferentes áreas estudiadas: "Política y Cultura" (40%), "Tabaquismo" (50%), "Alimentación" (10%), "Ejercicio Físico" (0%) y "Estrés" (0%). Un solo hospital obtuvo consideración de buenas prácticas en tres áreas, dos hospitales en dos áreas, tres hospitales en un área y cuatro no obtuvieron dicha clasificación en ningún área. CONCLUSIONES: Las estrategias de promoción de la salud implantadas en los hospitales de la Comunidad de Madrid encuestados son insuficientes en todas las áreas evaluadas. Se puede considerar que en todas estas materias se podría empezar por realizar estrategias de mejora, especialmente en "Ejercicio Físico", "Estrés" y "Alimentación" que son las más deficientes
OBJECTIVES: Cardiovascular disease is often caused by bad habits, and health promotion at work includes policies and activities designed to help workers control their own health and improve it. The objective of this study was the research of health promotion strategies in Comunidad de Madrid public hospitals to make improvements in the future in the areas with deficient results. MATERIAL AND METHODS: A descriptive observational prospective study was carried out with a email survey at 10 public hospitals in Comunidad de Madrid. The questionnaire that was used is the Move Europe available in Spanish at the INSST web page. Qualitative variables description was done with absolute frequency and percentages. RESULTS: The survey response rate was 100%. A very low percentage of centres that reached "good practices" was found: "Policy and Culture" (40%), "Smoking" (50%), "Nutrition" (10%), "Physical Activity" (0%) and "Stress" (0%). Only one hospital obtained "good practices" consideration in three areas, two hospitals in two areas, three hospitals in one area, and four of them didn't obtain that classification in any of the areas. CONCLUSIONS: The health promotion strategies implemented in the evaluated Comunidad de Madrid hospitals are not enough in all the studied areas. It can be considered that in all of this matters it could be possible to start strategies to promote improvement of them, especially in "Physical Activity", "Stress" y "Nutrition" that are the most deficient
Assuntos
Humanos , Masculino , Feminino , Promoção da Saúde/métodos , Doenças Cardiovasculares/prevenção & controle , Saúde Ocupacional/estatística & dados numéricos , Hospitais Públicos/estatística & dados numéricos , Estudos Prospectivos , Avaliação de Programas e Projetos de Saúde , Medicina do Trabalho , Fatores de Risco , Doenças Profissionais/prevenção & controle , Inquéritos e Questionários , Estilo de Vida Saudável , EspanhaRESUMO
La pandemia COVID-19 se ha propagado rápidamente por todo el mundo, produciendo una alta mortalidad. Ha obligado a reorganizar todos los sistemas sanitarios. La Unidad de Cuidados Paliativos del Hospital Universitario La Paz se transformó en una unidad para la atención a pacientes con infección por COVID-19 con el fin de colaborar en la atención a los mismos. Nos enfrentábamos al reto de asegurar un buen control de la sintomatología, que pasaba por una valoración lo más sistemática posible, siendo conscientes de la dificultad en el contexto del aislamiento y situación clínica de los pacientes. Presentamos una revisión narrativa sobre las manifestaciones sintomáticas y nuestra experiencia como Unidad de Cuidados Paliativos integrada en la atención COVID-19 en un hospital de tercer nivel de Madrid. Se priorizó un perfil de pacientes con enfermedad avanzada y comorbilidad alta para el ingreso en esta unidad. Esta integración contribuyó significativamente a tener una mayor influencia en la forma de actuación en la atención al final de la vida en todo el hospital. Los cuidados paliativos deben formar parte de los equipos de atención de cualquier emergencia sanitaria, como una pandemia. Es imprescindible para una adecuada atención de la sintomatología y del final de la vida. Es necesaria la recogida sistemática de los síntomas por la repercusión clínica que tiene sobre el paciente, la necesidad de un tratamiento específico y su implicación pronóstica
The COVID-19 pandemic has spread rapidly around the world, producing high mortality. It has forced the reorganization of all health systems. The Palliative Care Unit of the Hospital Universitario La Paz was transformed into a unit for the care of patients with COVID-19 infection in order to collaborate in the care of these patients. We faced the challenge of ensuring good control of the symptoms, which were assessed as systematically as possible, being aware of the difficulty in the context of the isolation and clinical situation of the patients. We present a narrative review of symptomatic manifestations and our experience as a Palliative Care Unit integrated in COVID-19 care in a third level hospital in Madrid. A profile of patients with advanced disease and high comorbidity was prioritized for admission in this unit. This integration contributed significantly to having a greater influence on the way end-of-life care is provided throughout the hospital. Palliative care should be part of the care teams in any health emergency, such as a pandemic. It is essential for adequate symptomatology and end-of-life care. Systematic collection of symptoms is necessary because of the clinical impact on the patient, the need for specific treatment and its prognostic implications
Assuntos
Humanos , Pessoa de Meia-Idade , Avaliação de Sintomas/métodos , Betacoronavirus , Infecções por Coronavirus/diagnóstico , Pneumonia Viral/diagnóstico , Cuidados Paliativos/métodos , Pneumonia Viral/terapia , Infecções por Coronavirus/terapia , Cuidados Paliativos na Terminalidade da Vida , Oxigenoterapia/instrumentaçãoRESUMO
INTRODUCTION: To study antibiotic susceptibility in bacterial keratitis (BK), its profile over 10 years and its influence on ophthalmological practice. METHODS: Retrospective review of BK with positive corneal scraping over a 10-year period. Risk factors for keratitis, visual acuity (VA), empirical topical treatment, corneal infection characteristics and outcomes were analyzed for BK due to Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Pseudomonas aeruginosa and Propionibacterium acnes. RESULTS: 389 positive corneal scrapings were collected. All Gram-positive bacteria were susceptible to vancomycin. P. aeruginosa demonstrated >90% sensitivity to the most-commonly-used topical antibiotics. Susceptibility to methicillin was 90.2% for S. aureus and 66.3% for S. epidermidis. The results of 215 patients were available. 1.9% required enucleation and 2.8% required surgical treatments. Final VA improved after treatment in keratitis due to S. aureus (p = 0.026) and S. epidermidis (p = 0.005). There was a correlation between S. aureus resistance to methicillin (p = 0.002) and levofloxacin (p = 0.043) and enucleation (20% and 10%, respectively) compared with a 0% rate of enucleation in S. aureus-susceptible keratitis. CONCLUSIONS: BK due to S. pneumoniae is very aggressive irrespective of antibiotic sensitivity. S. aureus was frequently isolated in patients with systemic diseases. It causes severe keratitis and remains moderately resistant to methicillin and levofloxacin. For this reason, keeping vancomycin in empirical regimens is believed to be necessary
INTRODUCCIÓN: Estudiar la susceptibilidad antibiótica en queratitis bacteriana (QB), el perfil temporal a lo largo de 10 años y su influencia en la clínica ocular. MÉTODOS: Revisión retrospectiva durante un periodo de 10 años de QB con raspado corneal positivo. Se analizaron los factores de riesgo de queratitis, la agudeza visual (AV), el tratamiento empírico tópico, las características de la infección corneal y el resultado clínico para QB por Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Pseudomonas aeruginosa y Propionibacterium acnes. RESULTADOS: Se recogieron 389 raspados corneales positivos. Todas las bacterias grampositivas fueron susceptibles a la vancomicina. P. aeruginosa presentó sensibilidad mayor del 90% a los antibióticos tópicos más comúnmente utilizados. La susceptibilidad a la meticilina fue del 90,2% para S. aureus y del 66,3% para S. epidermidis. Los resultados clínicos estaban disponibles para 215 pacientes. El 1,9% requirieron enucleación y el 2,8% tratamientos quirúrgicos. La AV final mejoró después del tratamiento en queratitis por S. aureus (p = 0,026) y por S. epidermidis (p = 0,005). Hubo correlación entre la resistencia de S. aureus a la meticilina (p = 0,002) y levofloxacino (p = 0,043) y enucleación (20 y 10%, respectivamente) en comparación con una tasa de enucleación del 0% en S. aureus susceptible. CONCLUSIONES: Las QB por S. pneumoniae son muy agresivas independientemente de la sensibilidad antibiótica. S. aureus se aisló con frecuencia en pacientes con enfermedades sistémicas, causa queratitis severa y permanece moderadamente resistente a la meticilina y a levofloxacino; debido a esto, consideramos necesario mantener la vancomicina en la pauta empírica
Assuntos
Humanos , Ceratite/microbiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Bactérias Gram-Positivas , Infecções por Bactérias Gram-Negativas/microbiologia , Bactérias Gram-Negativas , Antibacterianos/farmacologia , Acuidade Visual , Testes de Sensibilidade Microbiana , Estudos Retrospectivos , Fatores de Risco , EspanhaRESUMO
Introducción: La grasa abdominal y, sobre todo, su ganancia a lo largo del tiempo, se ha consolidado como un factor de riesgo cardiovascular en pacientes urémicos. Objetivos: Analizar los cambios en la grasa abdominal en los pacientes de hemodiálisis (HD) a lo largo de un año y estudiar sus posibles relaciones con los cambios en los niveles circulantes de adipocitocinas. Como objetivo secundario intentamos validar los datos obtenidos por bioimpedancia eléctrica (BIA) con los obtenidos por absorciometría dual de rayos X (DXA). Material y métodos: Se realizó un estudio prospectivo de un año de duración en 18 pacientes en HD. En cada paciente se cuantificó, basalmente y al cabo de un año, la composición corporal por BIA y DXA y se determinaron varios parámetros bioquímicos incluyendo adipocitocinas. Resultados: Se evidenció un aumento significativo del ángulo de fase [4,8° (4,1-5,6) frente a 5,2° (4,4-5,8); p<0,05], del agua intracelular por BIA [48,3% (43,1-52,3) frente a 50,3% (45,7-53,4); p<0,05] y del cociente entre el porcentaje de grasa de distribución androide/ginecoide (A/G) medido por DXA [1,00 (0,80-1,26) frente a 1,02 (0,91; 1,30); p<0,05]. Se encontró una relación estadísticamente significativa entre las concentraciones de leptina y adiponectina tanto con el porcentaje de masa grasa medida por BIA como con la grasa abdominal estimada mediante DXA (p<0,01). Conclusión: Los pacientes en HD experimentan una ganancia de grasa con el tiempo, especialmente en localización abdominal, evidenciada por un aumento del cociente A/G, lo que podría explicar el aumento del riesgo cardiovascular que presentan (AU)
Introduction: Abdominal fat and its increment over time in particular has become a cardiovascular risk factor in uraemic patients. Objectives: To analyse changes in abdominal fat in haemodialysis patients over one year and study their possible correlation with the variation in adipocytokine serum levels. As a secondary objective, we tried to validate the data obtained by bioelectrical impedance analysis (BIA) with data obtained by dual X-ray absorptiometry (DXA). Material and methods: A prospective one-year study was performed in 18 patients on haemodialysis (HD). In each patient, body composition by BIA and DXA was estimated at baseline and after one year. Several adipocytokine and biochemical parameters were determined. Results: A significant increase in phase angle [4.8° (4.1-5.6) vs. 5.2° (4.4-5.8), P<.05], BIA intracellular water [48.3% (43.1-52.3) vs. 50.3% (45.7-53.4), P<.05] and the ratio between the percentage of android/gynecoid (A/G) distribution of fat measured by DXA [1.00 (0.80-1.26) vs. 1.02 (0.91-1.30), P<.05] was observed. A statistically significant relationship between leptin and adiponectin concentrations and the percentage of fat mass measured by BIA, as well as the abdominal fat percentage estimated by DXA, was found (P<.01). Conclusion: HD patients exhibit a gain in fat mass over time, especially in the abdomen, evidenced by an increased A/G ratio. These findings might explain the increased cardiovascular risk in these patients (AU)
Assuntos
Humanos , Composição Corporal , Adipocinas/análise , Diálise Renal/estatística & dados numéricos , Uremia/fisiopatologia , Insuficiência Renal Crônica/complicações , Obesidade Abdominal/fisiopatologia , Diálise Peritoneal/estatística & dados numéricos , Fatores de Risco , Doenças Cardiovasculares/epidemiologia , Impedância Elétrica , Estudos Prospectivos , Pesos e Medidas Corporais/estatística & dados numéricosRESUMO
Objetivo: Relacionar los niveles de hormonas esteroideas foliculares con el ciclo de estimulación ovárica y sus resultados globales. Métodos: Se incluyeron pacientes < 38 años, con esterilidad de causa masculina, tubárica o desconocida, que recibieron un protocolo largo con agonistas de GnRH y rFSH. Se recogieron las muestras de la primera y segunda aspiración folicular de cada ovario y se realizó un quimioinmunoanálisis de estradiol, progesterona, testosterona y DHEAS. Resultados: Se obtuvieron cifras menores de DHEAS folicular en las pacientes con más días de frenado con agonistas de GnRH (p=0,0003). Cuantos más días de rFSH administrados, mayores fueron los niveles de testosterona y DHEAS folicular (p=0,03; p=0,03). En los resultados globales del ciclo, se obtuvo una correlación negativa entre las cifras de testosterona folicular y el número de complejos puncionados (r= -0,360; p=0,002) y entre la testosterona folicular y el número de embriones de calidad D (r= -0,233; p=0,047). El número de ovocitos maduros fue menor en pacientes con mayores niveles de testosterona folicular (p=0,008). La progesterona folicular fue superior en ovocitos de buena calidad frente a los de calidad no destacable (p=0,006) y muy mala calidad (p=0,04). Conclusiones: Las cifras altas de testosterona folicular se correlacionaron con menor número de complejos puncionados, ovocitos maduros y embriones de calidad D. La buena calidad ovocitaria se asoció a niveles de progesterona folicular superiores.
Objective: To relate the levels of follicular steroid hormones with the ovarian stimulation cycle and its overall results. Method: It was included patients < 38 years old with sterility of male, tubaric or unknown origin who underwent a long protocol with GnRH agonists and rFSH. Samples were obtained from the first and second follicular aspiration of each ovary. A chemiluminescent immunoassay of estradiol, progesterone, testosterone and DHEAS was performed. Results: Figures of follicular DHEAS decreased as the days of treatment with GnRH agonists increased (p=0.0003) and levels of follicular testosterone and DHEAS increased along with the days of treatment with rFSH (p=0.03, p=0.03). In regard to the outcomes of the overall cycle it was found a negative correlation between follicular testosterone levels and the number of punctured complexes (r= -0.360; p=0.002) and between follicular testosterone and the number of D quality embryos (r= -0.233; p=0.047). The number of mature oocytes was lower in patients with higher levels of follicular testosterone (p=0.008). Follicular progesterone was higher in good quality oocytes as compared to those of no remarkable quality (p=0.006) and very poor quality (p=0.04). Conclusions: High levels of follicular testosterone were correlated with a fewer number of punctured complexes, mature oocytes and D quality embryos. Good oocyte quality was associated with higher follicular progesterone levels.