Utilidad de la determinación de tiroglobulina en aspirado de ganglios linfáticos de pacientes con carcinoma papilar de tiroides y anticuerpos antitiroglobulínicos positivos / Usefulness of thyroglobulin determination in lymph node aspirates of patients with papillary thyroid carcinoma and positive antithyroglobulin antibodies

Objetivo: Precisar la utilidad de la determinación de tiroglobulina (Tg)en el líquido de lavado de la aguja de citología (Tg-PAAF) en el diagnóstico de adenopatías metastásicas de pacientes con cáncer papilarde tiroides (CPT) y anticuerpos antitiroideos positivos (AbTg).Material y métodos: Estudiamos a 11 pacientes (49,9 ± 11,8 años; el70%, mujeres) con antecedentes de CPT y concentraciones de AbTgséricas positivas quienes habían recibido tratamiento con 131I y mostraron captación patológica en el cuello compatible con adenopatías metastásicas. Se realizó punción aspirativa con aguja fina (PAAF) guiada; la aguja de punción se lavó con 1 ml de suero fisiológico y se determinóla Tg. Resultados: Se detectaron 17 nódulos sospechosos y 16 de ellos mostraron concentraciones de Tg en el líquido de lavado ≥ 7 ng/ml (223,3± 314,2 [7-1.009]). No se objetivaron AbTg en ellas. El rastreo corporaltotal (RCT) detectó el 94% de las adenopatías, mediante ecografía y citología se detectaron el 76,5 y el 70,6%, respectivamente. La Tg-PAAF fue positiva en el 94% de los nódulos, con superiorioridad al conjunto de ecografía y citología (88,2%) y la suma de los hallazgos ecográficos y Tg-PAAF detectó el 100% de los ganglios. Conclusiones: La determinación de Tg-PAAF es una técnica útil para el diagnóstico de adenopatías metastásicas de CPT y no resulta afectada por la presencia de AbTg séricos (AU)

Objective: We wanted to study the utility of thyroglobulin determination in the washout of fine needle aspiration (FNABTg) of lymph metastatic nodes in patients with papilar thyroid carcinoma (PTC) and positive serum thyroglobulin antibodies (AbTg).Materials and methods: We have studied 11 patients (49.9 ± 11.8 years old,70% females) with PTC and positive AbTgin which a whole-body scanning (WBS)after 131I treatment showed pathologicaluptake in lymph cervical nodes. An ultrasound-guided fine-needle aspiration biopsy (US-FNAB) was performed for cytological research. Needle-washout with1 ml ClNa 0.9% was employed to determine FNAB-Tg. Results: In 16/17 suspicious nodes Tg-FNAB concentration was higher than 7 ng/dl (223.3 ± 314.2 [7-1009]). AbTg were negative in the washout obtained. WBS was able to detect 94%lymphadenopathies, whereas 76.5% were detected with ultrasound and 70.6% using cytology. The FNAB-Tg was positive in 94%of nodules, which was higher than combining US and FNAB-cytology both together (88.2%). One hundred per cent of pathological nodules were detected using US plus FNAB-Tg. Conclusions: FNAB-Tg determination isan useful technique for diagnosis of metastatic lymph nodes of patients with PTC and is unaffected by the presence of serum AbTg (AU)

[Usefulness of the determination of thyroglobulin in lymph node aspirates of patients with papillary thyroid carcinoma and positive antithyroglobulin antibodies]. / Utilidad de la determinación de tiroglobulina en aspirado de ganglios linfáticos de pacientes con carcinoma papilar de tiroides y anticuerpos antitiroglobulínicos positivos.

OBJECTIVE: We wanted to study the utility of thyroglobulin determination in the washout of fine needle aspiration (FNAB-Tg) of lymph metastatic nodes in patients with papillar thyroid carcinoma (PTC) and positive serum thyroglobulin antibodies (AbTg). MATERIALS AND METHODS: We have studied 11 patients (49.9+/-11.8 years old, 70% females) with PTC and positive AbTg in which a whole-body scanning (WBS) after (131)I treatment showed pathological uptake in lymph cervical nodes. An ultrasound-guided fine-needle aspiration biopsy (US-FNAB) was performed for cytological research. Needle-washout with 1 ml ClNa 0.9% was employed to determine FNAB-Tg. RESULTS: In 16/17 suspicious nodes Tg-FNAB concentration was higher than 7 ng/dl (223.3+/-314.2 [7-1009]). AbTg were negative in the washout obtained. WBS was able to detect 94% lymphadenopathies, whereas 76.5% were detected with ultrasound and 70.6% using cytology. The FNAB-Tg was positive in 94% of nodules, which was higher than combining US and FNAB-cytology both together (88.2%). One hundred per cent of pathological nodules were detected using US plus FNAB-Tg. CONCLUSIONS: FNAB-Tg determination is an useful technique for diagnosis of metastatic lymph nodes of patients with PTC and is unaffected by the presence of serum AbTg.