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INTRODUCTION AND OBJECTIVES: The association between HDL cholesterol (HDL-C) levels and death from cardiovascular disease follows a U-shaped pattern, increasing at the extremes. The objective of the study was to characterize a sample of subjects with extreme hyperalphalipoproteinemia (HAE). MATERIAL AND METHODS: 53 cases with HAE were recruited, 24 women (HDL-C>135mg/ dL) and 29 men (HDL-C>116mg/ dL). A detailed medical history was taken and questionnaires on adherence to the Mediterranean diet and physical activity were collected. Carotid ultrasounds were performed to detect the presence of suclinical atherosclerosis. RESULTS: The most prevalent cardiovascular risk factor (CVRF) was dyslipidemia (64%) with no significant differences between men and women, unlike hypertension (21% in women, versus 55% in men, p=0.01) and others CVRF, for example, diabetes. 7% of the series had previous cardiovascular disease, women had higher LDL cholesterol (p=0.002) and HDL-C than men (without significant differences). Plaque was detected in 53% of cases, being more prevalent in men. Patients with plaque were older, drank more alcohol and smoked more (p<0.05). CONCLUSIONS: Men had a higher prevalence of CVRF than women, except for dyslipidemia. Subclinical atherosclerosis occurred in more than half of the series. Age, alcohol consumption and smoking were independently associated with the presence of plaque, however, our data do not show a significant influence of HDL-C levels.
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Humanos , Feminino , Idoso , Cálculos/complicações , Cálculos/diagnóstico por imagem , Duodenopatias/complicações , Duodenopatias/diagnóstico por imagem , Obstrução Intestinal/diagnóstico por imagem , Obstrução Intestinal/etiologiaAssuntos
Diabetes Mellitus , Endoftalmite , Infecções Oculares Bacterianas , Infecções por Klebsiella , Meningoencefalite , Antibacterianos/uso terapêutico , Endoftalmite/diagnóstico , Endoftalmite/tratamento farmacológico , Infecções Oculares Bacterianas/diagnóstico , Infecções Oculares Bacterianas/tratamento farmacológico , Humanos , Infecções por Klebsiella/complicações , Infecções por Klebsiella/diagnóstico , Infecções por Klebsiella/tratamento farmacológico , Klebsiella pneumoniae , Meningoencefalite/diagnóstico , Meningoencefalite/tratamento farmacológicoRESUMO
Cardiovascular disease risk is increased in survivors of testicular cancer because of exposure to treatment (chemotherapy and radiotherapy), as well as modification in lifestyle. Our aim was to assess the presence of subclinical arteriosclerosis in survivors of testicular cancer in comparison with a control group. This was a cross-sectional, observational, case-control study including 50 survivors of Germ Cell Tumor (GCT) (14 years of follow-up) and 53 age-matched controls with no cancer. We registered clinical data, cardiovascular risk factors, physical and Mediterranean questionnaires, intima-media thickness and plaque at carotid and femoral arteries by ultrasound, calcium score at the abdominal aorta, and liver steatosis by computed tomography, and applied analytical tests to quantify metabolic risk factors and inflammation markers. Patients showed a trend toward greater intima-media thickness (IMT) and plaques than controls, as well as a higher calcium score in the abdominal aorta. Remarkably, patients had higher waist circumference, insulin resistance (HOMA-IR), and liver steatosis, but lower physical activity and high-density lipoprotein (HDL) cholesterol than controls (all p < 0.05). In multivariate analyses, only common vascular risk factors were associated with subclinical arteriosclerosis. As a conclusion, in our study, a higher rate of subclinical arteriosclerosis in testicular cancer survivors was associated with classical metabolic risk factors and lifestyle, but not with exposure to chemotherapy.
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Obstrução Duodenal/etiologia , Cálculos Biliares/complicações , Obstrução da Saída Gástrica/etiologia , Dor Abdominal/etiologia , Idoso , Duodenopatias/fisiopatologia , Feminino , Cálculos Biliares/cirurgia , Obstrução da Saída Gástrica/diagnóstico , Humanos , Radiografia Abdominal/métodos , Vômito/etiologiaRESUMO
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Humanos , Masculino , Idoso , Obstrução Intestinal/etiologia , Artéria Mesentérica Superior/patologia , Síndrome da Artéria Mesentérica Superior/complicações , Tratamento Conservador , Obstrução Intestinal/diagnóstico por imagem , Artéria Mesentérica Superior/diagnóstico por imagem , Tomografia Computadorizada por Raios XAssuntos
Obstrução Intestinal/etiologia , Artéria Mesentérica Superior/patologia , Síndrome da Artéria Mesentérica Superior/complicações , Idoso , Tratamento Conservador , Humanos , Obstrução Intestinal/diagnóstico por imagem , Masculino , Artéria Mesentérica Superior/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
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