RESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso , Neoplasias da Mama/terapia , Carcinoma Basocelular/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Neoplasias Cutâneas/diagnóstico , Anilidas/uso terapêutico , Antineoplásicos/uso terapêutico , Carcinoma Basocelular/tratamento farmacológico , Segunda Neoplasia Primária/tratamento farmacológico , Piridinas/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Parede TorácicaAssuntos
Neoplasias da Mama/terapia , Carcinoma Basocelular/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Anilidas/uso terapêutico , Antineoplásicos/uso terapêutico , Carcinoma Basocelular/tratamento farmacológico , Feminino , Humanos , Segunda Neoplasia Primária/tratamento farmacológico , Piridinas/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Parede TorácicaRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Mama/patologia , Doenças Mamárias/etiologia , Doenças Mamárias/patologia , Linfoma de Células T/complicações , Biópsia , Necrose/etiologia , Tomografia por Emissão de PósitronsRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso , Acrospiroma/diagnóstico , Acrospiroma/cirurgia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Doenças das Glândulas Sudoríparas/diagnóstico , Doenças das Glândulas Sudoríparas/cirurgia , Imuno-Histoquímica , Diagnóstico PrecoceAssuntos
Acrospiroma , Neoplasias da Mama , Neoplasias das Glândulas Sudoríparas , Acrospiroma/diagnóstico , Acrospiroma/cirurgia , Idoso , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Feminino , Humanos , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/cirurgiaRESUMO
A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect of GLP-1, Ex-4 and Ex-9, compared with insulin upon the activity of PI3K, PKB, MAPKs and p70s6 kinases, and the participation of these enzymes in their action upon 2-deoxy-D-glucose transport by using potential inhibitors. The study was extended to morbidly obese patients. In normal subjects, GLP-1, Ex-4 and insulin, but not Ex-9, increased glucose uptake. In addition, GLP-1 and Ex-4 stimulated PI3K and MAPKs, similar to insulin, but not PKB. Ex-9 only enhanced PI3K, while none affected p70s6k. Inhibition of both PI3K and MAPKs blocked the stimulatory action of GLP-1, Ex-4 and insulin upon glucose transport. In obese patients, basal PI3K, PKB and MAPK activity was, as a rule, lower than that in normal subjects, while cells maintained their normal incremental response to GLP-1, Ex-4 or insulin; Ex-9 induced a clear stimulation of p42 MAPK. In summary, in normal human adipocytes, GLP-1 and Ex-4 have a protein kinase-dependent increasing effect upon glucose transport, which is impaired in obese patients. The participation of GLP-1 in the normalization of the metabolic conditions of the obese may occur through its effects on lipid metabolism or through effects upon glucose transport and/or metabolism in the liver and muscle, which in human obesity remain to be investigated.
