Experimental study of gene therapy on human gastric cancer with HSV-TK/GCV system / 中华消化杂志

2000 fold). In bystander effect experiment, the death rate of mixed cells was still over 50% even when they contained only 20% TK+ target cells. Fourteen days after nude mice bearing tumors were treated i.p. with GCV, the mean weight and volume of transfected tumors were less than those of untransfected tumors (P

Taurine attenuated ?-glycerophosphate-stimulated calcification in cultured rat vascular smooth muscle cells / 中国病理生理杂志

AIM: To investigate the effect of taurine on calcification of vascular smooth muscle cells (VSMCs).METHODS: Calcified VSMCs of rat in vitro were induced by ?-glycerophosphate. Cellular calcium content,alkaline phosphatase(ALP) activities and accumulation were measured. DNA synthesis were evaluated by -thymidine (-TdR) incorporation. RESULTS: Calcium content,ALP activities and uptake of calcified VSMCs stimulated by taurine (5-20 mmol/L) were greatly decreased in a concentration-dependent manner as compared with calcified group ( P

CGRP inhibits proliferation of vascular smooth muscle cells stimulated by Endothelin / 中国药理学通报

By means of 3H-Thymidine and3H-Leucine incorporation, we observed that CGRP inhibited the multiplication of SHR's aortic smooth muscle cells (VSMCs) and the proliferation of VSMCs stimulated by Endothelin. These results suggest that CGRP may be a natu-ral antagonist of Endothelin in human body.