The association between osteoporotic hip fractures and actinic lesions as a biomarker for cumulative sun exposure in older people-a retrospective case-control study in Argentina.

The aim of this study was to analyze the association between the presence of actinic lesions (solar keratosis and non-melanoma skin cancer) and osteoporotic hip fractures in older patients. Both pathologies are common conditions in this age group. Since cumulative sun exposure is difficult to quantify, the presence of actinic lesions can be used to indirectly analyze the association between ultraviolet radiation and osteoporotic hip fractures. This was an observational case-control study. We reviewed the centralized medical records of patients with hip fracture (cases, n = 51) and patients with other diseases hospitalized in the same institution and period (controls, n = 59). The mean age of the patients was 80 ± 8.3 years (range 50-103 years). Differences in maternal hip fracture history were found between cases and controls (14.8 and 8 %, respectively; p = 0.047). Falls history in the past year was higher in cases than in controls (p < 0.0001). Actinic lesions were observed in 32.7 % of patients (prevalence rate 23.5 % in cases, 40.7 % in controls; p = 0.04). When considering patients with actinic lesions, controls have a higher FRAX score compared with cases. Although sun exposure is recommended for bone health, it represents a risk factor for actinic lesions. The presence of actinic lesions may indicate a lower osteoporotic hip fracture risk. A balance between adequate lifetime sun exposure and protection against its adverse effects is required for each patient, in the context of geographic location.

Pénfigo benigno familiar con buena respuesta a metotrexate / Benign familial chronic pemphigus with and excellent response

La enfermedad de Hailey-Hailey o pénfigo familiar benigno es una gen dermatosis autosómica dominante ligada al gen ATP2C1 que se caracteriza por afectar áreas de pliegues simulando otras patologías, lo que genera un retraso en su diagnóstico y tratamiento. Se han propuesto numerosos tratamientos tópicos, físicos y sistémicos. Se presenta un caso clínico de enfermedad. de Hailey-Hailey con buena respuesta a metotrexate (AU)

Hailey-Hailey disease (familiar benign pemphigus) is a genodermatosis, inherited as an autosomal dominant condition. It affects the folds, simulating intertrigo or other different conditions, leading to a delay in diagnosis and treatment. Numerous topical, physical and systemic treatments have been proposed. We present a case of hailey hailey disease with and excellent response to metotrexate (AU)