Distribution of antigen-presenting cells CD68 in papillomavirus infection in the skin.

We analyzed local reactions of immune homeostasis in the human skin, in particular, effector immune cells CD68 responsible for antigen presentation, during human papillomavirus infection. Under conditions of long-term papillomavirus infection, CD68 markers were identifi ed only in the connective tissue of the skin (derma) and were completely absent in the epidermis, where they were found during physiological and reparative regeneration after thermal injury. We concluded that hypertrophy of the epidermis and connective tissue of the dermal papillary layer in human papillomavirus infection is related to the absence of CD68 immune cells in the epithelial plate and their accumulation in the connective tissue adjacent to the basement membrane of the epidermis. The possibility of epithelium contamination with the virus depends on local immune homeostasis. Therefore, induction of proper CD68 distribution in appropriate structures can contribute to normalization of epithelial-connective tissue interactions.

[Correction by sodium nucleinate of immunologic disorders in patients with atherosclerotic lesions of the arteries of the lower limbs]. / Korrektsiia nukleinatom natriia immunologicheskikh rasstroistv bol'nykh s ateroskleroticheskimi porazheniiami arterii nizhnikh konechnostei.

It is shown that sodium nucleinate applied in a complex with the generally accepted nonoperative therapy corrects the immune status of patients with atherosclerosis of the lower limb arteries in stage IIB circulatory disorders. The number of T-lymphocytes (45.2 +/- 1.22 before and 68.4 +/- 1.85 after treatment) and the percentage of B-lymphocytes (25.3 +/- 0.66 before and 19.3 +/- 0.66 after treatment) were normalized. The percentage of O-lymphocytes reduced 2.4 times, the number of T-lymphocytes sensitized to the arterial intima dropped to normal. The indices of humoral immunity improved: IgG reduced to the level encountered in healthy individuals, the level of circulating immune complexes reduced 2.23 times, the IgA concentration, however, remained just as low as before treatment. The indices of nonspecific immunity became normal: complement increased, the number of NST+ neutrophils reduced by half, the number and phagocytic activity of neutrophils significantly increased. In the group of patients who were given sodium nucleinate 18 had a good clinical effect.

[Types of microflora in acute suppurative-destructive diseases of the lungs and pleura]. / Kharakter mikroflory pri ostrykh gnoino-destruktivnykh zabole- vaniiakh legkikh i plevry.

By means of the modern bacteriologic methods, including gas-liquid chromatography, the microflora of the sputum, bronchial contents, pus from the abscess cavities and pleura in 106 patients with acute purulent destructive diseases of the lungs and pleura was studied.

[Immunological status of patients with atherosclerotic lesions of the vessels of the lower limbs]. / Immunologicheskii status bol'nykh s ateroskleroticheskimi porazheniiami sosudov nizhnikh konechnostei.

In 116 patients with atherosclerosis of the arteries of the lower extremities in stages I-IV of the impairment in circulation and 35 healthy subjects, the immune status was studied. With aggravation of the disease, the number of leukocytes, B-cells, concentration of the IgM, IgG and circulating immune complexes, the number of immature lymphocytes and T-cells sensitizised to antigens of the arterial intima increase. At the same time, the total activity of the complement and phagocytic activity of neutrophilic granulocytes decrease, the relative number of neutrophilic granulocytes, which spontaneously generate a superoxide radical, increases. The likeness of atherosclerosis of the lower extremities to atherosclerosis of the heart vessels was noted.

[Localization of Na+,K+-ATPase activity in the cardiac myocytes of white rats at the ultrastructural level]. / Lokalizatsiia aktivnosti Na+,K+-ATFazy v miotsitakh serdtsa belykh krys na ul'trastrukturnom urovne.

The localization of Na+,K+-ATPase in cardiomyocytes of white rats at the ultrastructural level and the dependence of enzyme activeness on electronic density of structures, were studied. Na+,K+-ATPase activity was revealed in plasmalemma, Z-membranes and in nuclei. The enzyme activity is distributed discretely both within the tissue and within separate cells. It is, probably, due to the heterogeneity of structural-functional condition of cells and their ultrastructures as revealed by means of electronic microscopy in terms of their different electronic density. The maximal Na+,K+-ATPase activeness was revealed at the average electronic density of structures.