[Advances and difficulties of present-day treatment of acute myeloblastic leukemia]. / Uspekhi i slozhnosti sovremennogo lecheniia ostrogo mieloblastnogo leikoza.

The success in acute myeloblastic leukemia (AML) treatment for the last 10 years has been referred to growing intensity of chemotherapy. The efficacy of treatment has been assessed in 56 patients under 60 years of age. Double induction of remission according to the scheme TAD-9 (2-day administration of cytosar) and consolidation by large-dose cytosar (1 g/m2) with rubomycin have increased the frequency of 2-year recurrence-free running from 13 to 35%. Resistance to treatment was absent. Maintenance prolonged total and recurrence-free survival. Mycosis and hepatitis were factors responsible for inadequate intensity of chemotherapy. These need more advanced prevention. The intensive double induction and consolidation did not raise general toxicity and immediate lethality compared to standard regimens which proved inferior to the proposed treatment.

[Experiences in transplanting bone marrow, leukocytes and human embryonic liver cells in hemoblastosis patients]. / Opyt transplantatsii kostnogo mozga, leikomassy i kletok émbrional'noi pecheni cheloveka bol'nym gemoblastozami.

The authors describe the experience gained with 19 allogenic and autologous transplantations of the bone marrow, peripheral blood leukocytes, embryonal liver cells of man and syngeneic transplantation of the bone marrow to 15 patients with hemoblastoses and aplastic anemia. Non-medullary toxicity of the pretransplantation conditioning of the patients was moderate and could be successfully corrected. The clinical analysis of the complications and causes of the patients' death demonstrated an evident reduction of organ lesions as a result of the use of the common methods of preventing exo- and endogenous infections and early treatment of the complications. The authors describe an acute secondary disease as the main reason for death during the latest allogenic transplantations of the bone marrow and support the conclusion about the necessity of transplantation only in the cases with a satisfactory prognosis.