[Pneumonia or drug-related exogenic allergic alveolitis? Key role of anamnesis in differential diagnosis].

A case is reported of an old female patient with exogenic allergic alveolitis which was first diagnosed as pneumonia progressing in the presence of long-term and intensive antibiotic treatment. Detailed analysis of the case history gave grounds for suspected drug-related exogenic allergic alveolitis. Discontinuation of antibiotics, administration of glucocorticoids and antiplatelet drugs led to recovery.

[The effectiveness of antibiotics in typical and atypical pneumonias depending on combination with glucocorticosteroids].

Sixty-seven cases of prolonged pneumonia were analyzed. The study found that in cases with a typical onset the efficacy of antibiotics with predominantly bactericidal activity was much higher when they were administered in combination with glucocorticosteroids (GCS); bacteriostatic preparations were not used in such cases. In prolonged pneumonia with an atypical onset the efficacy of mainly bacteriostatic antibiotics was significantly higher than that of bactericidal ones, but the efficacy of both did not increase when they were combined with GCS. The use of GCS in addition to antibiotics shortens the time to pneumonia resolution in cases with both typical and atypical onset, regardless the character of antibacterial therapy.

[Fatal outcomes of caseous pneumonia in alcohol abusers]. / Letal'nye iskhodi kazeoznoi pnevmonii u lits, zloupotrebliaiushchikh alkogolem.

In alcoholics, caseous pneumonia is characterized by a malignant progressive course and therapy resistance. The toxic allergic syndrome in such patients may be a diagnostic sign of transition of benign forms of tuberculosis to caseous pneumonia.

[Protracted pneumonia: risk factors and therapeutic policy]. / Zatiazhnaia pnevmoniia: faktory riska i lechebnaia taktika.

AIM: Analysis of the onset and course of lingering pneumonia (LP) to reveal its risk factors and assess its treatment efficacy depending on the presence of the above factors. MATERIALS AND METHODS: A retrospective analysis has been made of 67 cases of nonhospital pneumonia running for more than 4 weeks. RESULTS: A positive correlation was found between LP duration and time since LP onset till hospitalization, gamma-globulin level on the hospitalization day, number of antibiotics used in LP treatment. Early short-term administration of glucocorticosteroids and heparin reduced LP duration, frequency of pleurisy and pneumopleurofibrosis. CONCLUSION: Positive correlation between pneumonia duration and number of the antibiotics may be due to sensitization of the patients as a result of large doses of various antibiotics and persistence of infiltration in the lungs with its further transformation into fibrosis, especially in the presence of immune disorders.

[Tuberculous peritonitis in emergency surgical care]. / Tuberkuleznyi peritonit v klinike urgentnoi khirurgii.

The paper presents 5 cases of histologically verified tuberculous peritonitis followed up by the author in 1994-1996. All patients were admitted to hospital and undergone surgical intervention for emergency indications. The main symptoms were intoxication, abdominal pain and enlargement. Two typical cases are described. Tuberculous peritonitis is recommended to be included into the differential diagnostic list of acute surgical abdominal diseases.

[Effect of ceruloplasmin conformation on its activity: significance for clinical analysis]. / O vliianii konformatsii tseruloplazmina na ego aktivnost': znachenie dlia klinicheskogo analiza.

Conformational properties of ceruloplasmin were studied immediately in blood serum of healthy volunteers, patients with tuberculosis, with pulmonary cancer, with pneumonia and with Wilson-Konovalov disease. The glycoprotein conformation was found to depend on the volunteer physiological state and/or available pathology. The ceruloplasmin conformation and status of its copper-containing sites of the I type affected the enzyme oxidase properties and hence routine colorimetric procedures require some corrections for estimation of ceruloplasmin concentration and activity in blood serum.

[Tuberculosis and pneumonia]. / Tuberkulez i pnevmonia.

Analysis of the clinical course of acute pneumonia in pulmonary tuberculosis patients is presented. The lowest rate of acute pneumonia morbidity was found in patients with active tuberculosis during antituberculosis therapy. As soon as the specific process subsides and its activity diminishes acute pneumonia morbidity grows. Specific features of the course of acute pneumonia in patients with different phases of tuberculosis development are shown. Data on the study of liquid-crystal thermography are presented as well as the assessment of the capillary blood flow and the results of immunologic study in the presence of combined pathology. The terms of alleviation of acute pneumonia in tuberculosis patients are delayed, especially in inflammation development in the zones of post-tuberculosis changes.