The standardized perioperative treatment of chronic rhinosinusitis with nasal polyps and asthma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To discuss the perioperative treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma.@*METHOD@#Retrospective analysis of perioperative clinical data of 43 cases with CRSwNP and asthma. The admitted and under endoscopic surgery. Patients with preventing perioperative asthma attacks and corresponding standardized treatment were Observed.@*RESULT@#Thirty-five cases were stable during perioperative period and without asthma. Seven patients diagnosed as mild and moderate asthma attacks because of low pulse oximetry (SpO2 92%-95%) and scattered wheeze heard in the lungs. So these patients were sent to ICU for the treatment. They went back to ward after their conditions turned to stable and no asthma during perioperative. One patient diagnosed as severe asthma attack, because irritability and suffocation happened, SpO2 decreased from 99% to 84%-81%, diffuse wheeze could be heard in the whole lung . So we give him tracheal intubation and sent him to ICU for advanced treatment after breathing smooth. Five days later the patient retuned to the ward in stable condition and with no asthma attack again.@*CONCLUSION@#Before operation the patients should be give some corresponding standardized comprehensive treatment according to the nasal symptoms and the degree of asthma attack, such as the application of topical steroid and antiallergic medicine. And some special treatment should be given to reduce airway hyperresponsiveness mucosa during anesthesia. These methods can reduce the risk of the asthma attacks and improve perioperative safety, prevent serious complications.

Rabbit is suitable for establishing an animal model of rhino-sinusitis / 中国组织工程研究

BACKGROUND:Using experimental animals to simulate diseases of human being is the basis of studying etiology and treatment of the diseases, so the diseases of nasal cavity and sinus need suitable experimental animals as models. OBJECTIVE:To observe the regional anatomy of rhino-sinus in rabbits and its performance through CT imaging, and to discuss the feasibility of applying a rabbit model to the study of animal rhino-sinusitis. METHODS:Routine coronal and axial scanning images of rhino-sinus of New Zealand rabbits were performed through Discovery CT750 HD. The rhino-sinus anatomy was then observed. RESULTS AND CONCLUSION:The nasal septum is located on both sides of the nasal cavity. The lateral wal of rabbit nasal is composed of maxil ary turbinate, middle turbinate, the inside of the middle turbinate and inferior turbinate. The maxil ary sinus cavity is the largest one and ethmoid sinus, sphenoid sinus and frontal sinus are relatively much smal er. Al these sinuses are paired and symmetrical. The rhino-sinus in rabbit is displayed clearly in CT scan. The anatomical location of rabbit is similar to that of human;however, the maxil ary sinus of rabbit is greater than that of human correspondingly, which is suitable for operating and applying to surgical anatomy and imaging analysis. The rabbit model of rhino-sinus can be applied to simulate human rhino-sinusitis.