Assuntos
Doenças Placentárias , Vasculite , Gravidez , Feminino , Humanos , Linfócitos T , Placenta , Córion , Vasculite/diagnósticoRESUMO
Fibrin-associated diffuse large B-cell lymphoma (fibrin-associated DLBCL) is a very rare subtype of Epstein-Barr virus (EBV)-associated DLBCL that usually develops within fibrin-rich lesions such as cardiac myxoma, chronic hematoma, thrombus, pseudocysts or cysts, prosthetic devices or breast implants. The pathogenesis as well as the clinicopathologic features of this usually indolent lymphoproliferative disorder, which are based on the analysis of a relatively limited number of cases, are still poorly known. Herein, we report a case of fibrin-associated DLBCL that was incidentally found within a multinodular goiter, a location not yet reported to our knowledge. Our findings not only illustrate further the specific nature of this peculiar lymphoproliferative disorder but also allow some interesting comments on its pathogenesis.
Assuntos
Infecções por Vírus Epstein-Barr , Bócio , Linfoma Difuso de Grandes Células B , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/diagnóstico , Infecções por Vírus Epstein-Barr/patologia , Fibrina , Herpesvirus Humano 4 , Humanos , Linfoma Difuso de Grandes Células B/patologiaAssuntos
Canal Anal , Condiloma Acuminado/diagnóstico , Sífilis Cutânea/diagnóstico , Sífilis/diagnóstico , Treponema pallidum/isolamento & purificação , Adulto , Canal Anal/microbiologia , Canal Anal/patologia , Canal Anal/cirurgia , Diagnóstico Diferencial , Humanos , Masculino , Valor Preditivo dos Testes , Sífilis/microbiologia , Sífilis/patologia , Sífilis/cirurgia , Sífilis Cutânea/microbiologia , Sífilis Cutânea/patologia , Sífilis Cutânea/cirurgiaRESUMO
According to the literature, serrated lesions and polyps of the appendix are extremely rare in children or teenagers. Herein, we present the pathologic and molecular features of a sessile serrated lesion (SSL) that was incidentally found in the appendix of a teenage girl. Our findings not only illustrate that appendiceal SSL may occur in young patients such as teenagers but also confirm further that BRAF V600E mutation may be found in a subset of these neoplastic lesions.
Assuntos
Apêndice/patologia , Doenças do Ceco/patologia , Proteínas Proto-Oncogênicas B-raf/genética , Adolescente , Doenças do Ceco/diagnóstico , Doenças do Ceco/genética , Feminino , Marcadores Genéticos , Humanos , Achados Incidentais , Mutação PuntualRESUMO
Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.
Assuntos
Células Matadoras Naturais/patologia , Linfonodos/patologia , Linfoma/patologia , Transtornos Linfoproliferativos/patologia , Adulto , Infecções por Vírus Epstein-Barr/virologia , Gastroenteropatias/patologia , Trato Gastrointestinal/patologia , Humanos , Enteropatias/diagnóstico , Enteropatias/patologia , Linfoma/diagnóstico , Transtornos Linfoproliferativos/diagnóstico , Transtornos Linfoproliferativos/virologia , MasculinoRESUMO
We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm.
Assuntos
Pseudolinfoma/diagnóstico , Pseudolinfoma/terapia , Dermatopatias/diagnóstico , Dermatopatias/terapia , Pré-Escolar , Humanos , Masculino , Pseudolinfoma/etiologia , Dermatopatias/etiologiaAssuntos
Dor Abdominal/etiologia , Sarcoma de Células Dendríticas Foliculares/complicações , Infecções por Vírus Epstein-Barr/complicações , Granuloma de Células Plasmáticas/complicações , Idoso , Sarcoma de Células Dendríticas Foliculares/diagnóstico por imagem , Sarcoma de Células Dendríticas Foliculares/patologia , Infecções por Vírus Epstein-Barr/diagnóstico , Feminino , Granuloma de Células Plasmáticas/diagnóstico por imagem , Granuloma de Células Plasmáticas/patologia , Humanos , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Chromosome abnormalities are important prognostic factors in myeloma allowing risk stratification of patients. Different techniques are available for their detection including cytogenetics, Fluorescent In Situ Hybridisation (FISH) and array Competitive Genomic Hybridisation (CGH). This study aimed to assess the validity and usefulness of each technique in a diagnostic setting. METHODS: 112 myeloma cases were analysed by whole bone marrow cytogenetics and by FISH and array CGH performed on purified plasma cell populations. RESULTS: Clonal abnormalities were identified in 30% of cases by cytogenetics and 97% by FISH and array CGH. By combining array and FISH results abnormalities were detected in 99% of cases and, if cytogenetic analysis was also considered, abnormalities were detected in 100% of cases. CONCLUSIONS: Cytogenetic analysis is of limited value in myeloma. Array CGH and FISH are highly specific tests allowing the identification of aberrations in virtually all cases. The two techniques are complementary and need to be combined in order to provide a comprehensive analysis of all clinically relevant aberrations in myeloma.
Assuntos
Biomarcadores Tumorais/genética , Aberrações Cromossômicas , Cromossomos Humanos , Hibridização Genômica Comparativa , Análise Citogenética , Perfilação da Expressão Gênica/métodos , Hibridização in Situ Fluorescente , Mieloma Múltiplo/genética , Variações do Número de Cópias de DNA , Predisposição Genética para Doença , Humanos , Mieloma Múltiplo/patologia , Fenótipo , Ploidias , Valor Preditivo dos Testes , Translocação GenéticaRESUMO
Plasmacytoid dendritic cells (PDC) belong to a subtype of dendritic cells that are normally absent in healthy skin. In some inflammatory diseases of the skin, especially lupus erythematosus (LE), these cells are occasionally recruited in great amounts, which can be used as a helpful clue for diagnosis. Rarely, PDC may also accumulate in the skin of patients with myeloid leukemia, a yet poorly known condition currently called 'tumor-forming PDC associated with myeloid neoplasms'. In this study, we describe a patient with unsuspected chronic myelomonocytic leukemia who developed cutaneous lesions characterized by a dermal infiltrate rich in PDC. Similarly to LE, such neoplastic PDC were accompanied by interface dermatitis-like changes, but displayed an aberrant phenotype and shared the same chromosomal abnormality with the leukemic cells identified in the bone marrow, thus revealing the neoplastic nature of the process. This observation illustrates that tumor-forming PDC associated with myeloid neoplasms may microscopically mimic LE in some patients. Accordingly, a hematologic workup is recommended in any skin lesion featuring excessive numbers of PDC, even if morphological alterations suggestive of interface dermatitis are found.
Assuntos
Células Dendríticas , Derme , Leucemia Mieloide , Lúpus Eritematoso Cutâneo , Plasmócitos , Neoplasias Cutâneas , Células Dendríticas/metabolismo , Células Dendríticas/patologia , Derme/metabolismo , Derme/patologia , Humanos , Leucemia Mieloide/metabolismo , Leucemia Mieloide/patologia , Lúpus Eritematoso Cutâneo/metabolismo , Lúpus Eritematoso Cutâneo/patologia , Masculino , Pessoa de Meia-Idade , Plasmócitos/metabolismo , Plasmócitos/patologia , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologiaAssuntos
Cistadenoma/patologia , Cisto Folicular/patologia , Folículo Piloso/patologia , Neoplasias das Glândulas Sebáceas/patologia , Glândulas Sebáceas/patologia , Siringoma/patologia , Biomarcadores Tumorais/análise , Biópsia , Diferenciação Celular , Cistadenoma/química , Cistadenoma/cirurgia , Cisto Folicular/química , Cisto Folicular/cirurgia , Folículo Piloso/química , Folículo Piloso/cirurgia , Humanos , Imuno-Histoquímica , Queratina-17/análise , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Neoplasias das Glândulas Sebáceas/química , Neoplasias das Glândulas Sebáceas/cirurgia , Glândulas Sebáceas/química , Glândulas Sebáceas/cirurgia , Siringoma/química , Siringoma/cirurgiaRESUMO
A cutaneous infiltrate composed of plasmacytoid dendritic cells may occasionally occur in a patient suffering from a myeloid neoplasm. To date, the clinical and pathological features associated with this event remains poorly characterized. Herein, we report a patient with acute myeloid leukemia who developed pruritic papules or erythematous plaques scattered on the skin. Microscopic examination showed a dermal infiltrate rich in plasmacytoid dendritic cells expressing CD4, CD43, CD68, granzyme B, CD123, CD303 [blood dendritic cell antigen 2 (BDCA-2)], CD2-associated protein (CD2AP) and T-cell leukemia/lymphoma oncogene 1 (TCL1). Our observation illustrates further that cutaneous lesions associated with some myeloid neoplasms, especially those featuring a monocytic component, may be composed of plasmacytoid dendritic cells. Because of differences in clinical, pathological and genetic features, this rare condition should be distinguished from blastic plasmacytoid dendritic cell neoplasm.
Assuntos
Células Dendríticas/patologia , Leucemia Mieloide Aguda/diagnóstico , Plasmócitos/patologia , Plasmocitoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Biomarcadores Tumorais/metabolismo , Células Dendríticas/metabolismo , Derme/metabolismo , Derme/patologia , Diagnóstico Diferencial , Humanos , Leucemia Mieloide Aguda/metabolismo , Masculino , Plasmócitos/metabolismo , Plasmocitoma/metabolismo , Neoplasias Cutâneas/metabolismoRESUMO
Secondary localization of chronic lymphocytic leukemia (CLL) in breast is rare, while concurrent invasive ductal carcinoma and CLL manifesting as a collision tumor in breast is extremely rare. The observation of a CLL infiltration closely associated with a distinct breast neoplasm with the absence of any other localization for the leukemia is an indisputable argument for a relationship between the two diseases. The presence of both tumors is not simply due to chance. This association (CLL and carcinoma) has also been described in other organs. Hereafter, we report a second case of an 80 year-old woman in whom a leukemic infiltrate was confined to the region immediately surrounding poorly differentiated primary breast carcinoma, and we will discuss the association between CLL and carcinoma.
Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/patologia , Leucemia Linfocítica Crônica de Células B/patologia , Recidiva Local de Neoplasia/patologia , Segunda Neoplasia Primária/patologia , Idoso de 80 Anos ou mais , Mama/patologia , Diagnóstico Diferencial , Feminino , Humanos , Infiltração Leucêmica/patologiaAssuntos
Medula Óssea/patologia , Doenças Mieloproliferativas-Mielodisplásicas/diagnóstico , Baço/patologia , Translocação Genética , Autoantígenos/genética , Proteínas de Ciclo Celular/genética , Cromossomos Humanos Par 8 , Cromossomos Humanos Par 9 , Humanos , Janus Quinase 2/genética , Masculino , Pessoa de Meia-Idade , Doenças Mieloproliferativas-Mielodisplásicas/genéticaAssuntos
Hiperplasia Angiolinfoide com Eosinofilia/imunologia , Hiperplasia Angiolinfoide com Eosinofilia/patologia , Células Dendríticas/imunologia , Hiperplasia Angiolinfoide com Eosinofilia/metabolismo , Antígenos CD/metabolismo , Células Dendríticas/metabolismo , Humanos , Imunofenotipagem , Masculino , Pessoa de Meia-IdadeRESUMO
Alimentary tract duplications are rare congenital malformations that occur most commonly in the jejunoileal part of the gastrointestinal tract. Management of this pathologic condition is usually drawn up. We report a case of descending colonic communicating duplication in which clinical presentation and anatomopathologic results were unexpected. A slightly echogenic abdominal mass reaching 72 x 36 mm in the left flank was diagnosed in a female fetus during the third trimester ultrasound examination. At birth, volume of the mass rapidly evolved, and despite no intestinal obstruction was observed by compression of the adjacent gastrointestinal tract, abdomen was distended. Abdominal plain film showed a large air collection, and the barium enema demonstrated a slight leak of contrast in the aerated mass, suggesting a communication with the sigmoid colon. No other abnormalities were seen. The patient underwent surgery in emergency. The mass was then totally excised through an antimesenteric resection of the tubular tract joining cystic mass and sigmoid colon. A lateral suture of the colon was subsequently performed. The wall of the duplication is usually composed of a smooth muscle layer covered by an epithelium, mostly of intestinal type. Herein, we describe a descending colonic duplication completely lined with nonkeratinizing squamous epithelium. Therefore, the association of a colonic mucosa (of endodermic origin) and a squamous epithelium (derived from the ectoderm) in our case is an interesting finding and is not explained by the various theories. Furthermore, the clinical characteristics, diagnosis, and treatment of intestinal duplications are discussed with regard to literature.