RESUMO
Twenty patients of various types of leprosy were skin tested with lepromin, PPD and DNCB to assess their immunological status. Two of the twenty (18 BT; 2 BB) patients belonging to BT type developed signs of acute neuritis of sudden onset about 4 weeks after the test with DNCB, lepromin and PPD. The patients were on DDS therapy already for the last 3-4 months. Presumably DNCB, PPD or lepromin testing had precipitated the reaction. A suggestion is made that lepromin a lower concentration could be used initially and if it gives negative reaction, a higher concentration may be used as in case of PPD testing, particularly in TT and BT cases already put on treatment.
Assuntos
Dinitroclorobenzeno/imunologia , Antígeno de Mitsuda/imunologia , Hanseníase/imunologia , Nitrobenzenos/imunologia , Adulto , Dapsona/uso terapêutico , Humanos , Irritantes , Hanseníase/tratamento farmacológico , Masculino , Neurite (Inflamação)/etiologia , Testes Cutâneos , Teste TuberculínicoRESUMO
Well-defined margin in a patch of leprosy indicates good cell mediated immunity (CMI) and containment of the disease process within the lesion. A study was hence undertaken to ascertain if histological changes in well marginated lesion are confined to the involved area alone or extend into the surrounding normal looking skin.
