Comparative study of plaque surface temperature and blood heat transfer in a stenosed blood vessel with different symmetrical configurations.

The presence of macrophage cells inside plaque can lead to a change in plaque temperature, which can be measured by using arterial wall thermographic techniques to predict the severity of stenosis in the vessel without complicated surgery. This study aims to analyze the effect of plaque symmetricity with a similar degree of stenosis (DOS) on plaque surface temperature and blood heat transfer in a straight vessel. This analysis aims towards predicting the severity of stenosis in a straight blood vessel through plaque temperature as an indicator. Two cases are being analyzed here; case 1 and case 2 refer to having similar vessel dimensions and an overall degree of stenosis (DOS) of 70%, with the exception of case 1 having a symmetrically developed plaque while case 2 refers to an asymmetrically developed plaque. Euler-Euler multiphase method with the application of the granular model is being applied in this study. At peak systole (0.2 s into the 10th cardiac cycle) in a cardiac cycle, the increase in plaque surface temperature at exit is higher in case of a symmetrically developed stenosis compared to an asymmetric one but the reverse situation happens during end systole (0.5 s into the 10th cardiac cycle). Although the population of macrophages in a plaque is a deciding factor of the thermal signature of a plaque, the symmetricity variation also needs to be taken into consideration while plaque progression is being diagnosed through thermographic technique.

Consequence of Red Blood Cells Deformability on Heat Sink Effect of Blood in a Three-Dimensional Bifurcated Vessel.

Several diseases like Sickle Cell Anemia, Thalassemia, Hereditary Spherocytosis, Malaria, and Micro-angiopathic Hemolytic Anemia can alter the normal shape of red blood cells (RBCs). The objective of this study is to gain insight into how a change in RBC deformability can affect blood heat transfer. The heat sink effect in a bifurcated vessel with two asymptotic cases (case 1: deformable and case 2: nondeformable RBCs) is being studied during hyperthermia treatment in a three-dimensional bifurcated vessel, whose wall is being subjected to constant heat flux boundary condition. Euler-Euler multiphase method along with the granular model and Kinetic theory is used to include the particle nature of RBCs during blood flow in the current model. To enhance the efficiency of the numerical model, user-defined functions (UDFs) are imported into the model from the C++ interface. The numerical model used is verified with the experimental results from (Carr and Tiruvaloor, 1989, "Enhancement of Heat Transfer in Red Cell Suspensions In Vitro Experiments," ASME J. Biomech. Eng., 111(2), pp. 152-156; Yeleswarapu et al. 1998, "The Flow of Blood in Tubes: Theory and Experiment," Mech. Res. Commun., 25(3), pp. 257-262). The results indicate that the deformability of RBCs can change both the flow dynamics and heat sink effect in a bifurcated vessel, which subsequently affects the efficacy and efficiency of the thermal ablation procedure. Both spatial and transient Nusselt numbers of blood flow with deformable RBCs are slightly higher compared to the one with nondeformable RBCs.

Study of heat sink effect of blood in a bifurcated vessel.

Thermal ablation treatment uses elevated (hyperthermia) or depressed (hypothermia) tissue temperature to destroy tumor cells. The efficacy and effectiveness of thermal ablation therapy is dependent on the tissue temperature which is significantly affected due to heat sink effect of blood flow near the infected site. In this study, Euler-Euler multiphase model is used to analyze the effect of plasma and RBC concentration on the heat sink effect of blood in a bifurcated vessel. This study is divided into two separate cases. First case refers to the study of heat sink effect produced by a tumor patient suffering from HVS (hyperviscosity syndrome) and a normal (without blood disorder) tumor patient during hyperthermia treatment. The second case analyses the effect of RBCs on blood heat transfer. Temperature distribution and transient Nusselt number, which are used to represent heat sink effect, are calculated and compared for different cases of blood disorders. From the results, it is found that a patient with HVS blood disorder produces a smaller heat sink effect during hyperthermia treatment compared to a normal tumor patient. Also, the level of RBC concentration in the blood stream has a minimal effect on heat transfer.

Effect of collision, size, and oscillation of RBCs on blood heat transfer in a bifurcated vessel.

This study attempts to analyze the effect of red blood cells (RBCs) on blood heat transfer in a three-dimensional bifurcated vessel when treated with hyperthermia procedure. A two-phase granular model is used in this paper to study the various underlying factors that affect the flow dynamics of RBCs in a blood vessel. Separate cases are analyzed to study the effect of RBC size, RBC-RBC, and RBC-wall collision and oscillation on heat transfer in a three-dimensional bifurcated vessel under pulsatile flow condition. Blood temperature and transient Nusselt number are used as heat transfer representative parameters. A good agreement with the experimental results from the existing literature is observed when the numerical model used in this study is compared for accuracy. From this study, it has been found that an increase in the size of RBCs of a blood disorder patient can decrease the temperature of blood compared to a normal patient when subjected to hyperthermia treatment. A change in the nature of collision between RBCs does not affect the heat transfer of blood under pulsatile flow condition in a bifurcated vessel. Also, an increase in granular temperature or oscillation of RBCs slightly increases the blood temperature when exposed to thermal treatment.