Thiourea Functionalised Receptor for Selective Detection of Mercury Ions and its Application in Serum Sample.

A thiourea functionalised fluorescent probe 1-phenyl-3-(pyridin-4-yl)thiourea was synthesized and utilised as a fluorescent turn-on chemosensor for the selective recognition of Hg2+ ion over competitive metal ions including Na+, Mn2+, Li+, Cr2+, Ni2+, Ca2+, Cd2+, Mg2+, K+, Co2+, Cu2+, Zn2+, Al3+ and Fe2+ ions based on the inter-molecular charge transfer (ICT). Intriguingly, the receptor demonstrated unique sensing capabilities for Hg2+ in DMSO: H2O (10:90, v/v). The addition of Hg2+ ions to the sensor resulted in a blue shift in the absorption intensity and also enhancement in fluorescence intensity at 435 nm. Fluorescence emission intensity increased linearly with Hg2+ concentration ranging from 0 to 80 µL. The detection limit and binding constant were determined as 0.134 × 10-6 M and 1.733 × 107 M-1, respectively. The sensing behavior of Hg2+ was further examined using DLS, SEM and FTIR. The probe could detect Hg2+ ions across a wide pH range. Furthermore, the receptor L demonstrated good sensing performance for Hg2+ in bovine serum albumin and actual water samples.

Advances on fluorescence chemosensors for selective detection of water.

Water, although an important part of everyday life, is acts as one of the most significant contaminants in various applications such as biomedical monitoring, chemical production, petroleum-based fuel and food processing. In fact, the presence of water in other solvents is a huge concern. For the quantification of trace water content, different methods such as Karl-Fischer, electrochemical, nuclear magnetic resonance, chromatography, and thermogravimetric analysis have been used. Although every technique has its own benefit, each one suffers from several drawbacks that include high detection costs, lengthy procedures and specialized operations. Nowadays, the development of fluorescence-based chemical probes has become an exciting area of research for the quick and accurate estimation of water content in organic solvents. A variety of chemical processes such as hydrolysis reaction, metal ions promoted oxidation reaction, suppression of the -C═N isomerization, protonation and deprotonation reactions, and molecular aggregation have been well researched in the last few years for the fluorescent detection of trace water. These chemical processes eventually lead to different photophysical events such as aggregation-induced emission (AIE), aggregation-induced emission enhancement (AIEE), aggregation-caused quenching (ACQ), fluorescent resonance energy transfer (FRET), charge transfer, photo-induced electron transfer (PET), excited state intramolecular proton transfer (ESIPT) that are responsible for the detection. This review presents a summary of the fluorescence-based chemosensors reported in recent years. The design of water sensors, sensing mechanisms and their potential applications are reviewed and discussed.

A Formyl Chromone Based Schiff Base Derivative: An Efficient Colorimetric and Fluorescence Chemosensor for the Selective Detection of Hg2+ Ions.

A novel chromone-based Schiff base L was designed and synthesized by condensing an equimolar amount of 3-formyl chromone and 2,4-dinitro phenyl hydrazine. Schiff base L was developed as a potent colorimetric and fluorescent molecular probe to recognize Hg2+ ions over other competitive metal ions. In the presence of Hg2+, Schiff base L displays a naked-eye detectable color change under day and UV365 nm light. Various UV-Vis and fluorescence studies of L were performed in the absence and presence of Hg2+ to determine the sensitivity and the sensing mechanism. With high selectivity and specificity, the detection limit and association constant of L for Hg2+ were estimated at 1.87 µM and 1.234 × 107 M-1, respectively. The developed sensor L was applied to real soil samples for the detection of Hg2+.