1.
Org Biomol Chem
; 17(38): 8726-8736, 2019 10 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31549116
RESUMO
G-triplex nucleic acid structures (G3) have been conjectured to form in vivo but little is known about their physiological functions. The identification of ligands capable of specific binding to G3 structures is therefore highly appealing but remains elusive. Here we report on the assembly of a DNA conjugate which folds into a stable G3 structure. The structural mimic was used to probe the interactions between a G3 ligand and first-in-class G4 ligands, revealing signification binding promiscuity.