1.
Org Lett
; 3(19): 3025-7, 2001 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11554834
RESUMO
Treatment of the diol 6 with KH and 18-C-6 at room temperature gives the cyclopentenone 7 in good yields. Mechanistic analysis reveals that this is the first case of an anionic oxy retro-ene reaction followed by a tandem intramolecular aldol condensation. Reaction: see text.
Assuntos
Cardiotônicos/síntese química , Ciclopentanos/síntese química , Álcoois/química , Ânions , Modelos Moleculares , Ouabaína/síntese química , Oxirredução , Estereoisomerismo
2.
Org Lett
; 3(4): 627-9, 2001 Feb 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11178842
RESUMO
[reaction: see text] Anomalous ozonolysis of strained bicyclic allylic alcohols yields alpha-hydroxymethyl ketones. The proposed mechanism involves an unusual trapping of the primary ozonide that undergoes a Grob-like fragmentation instead of dissociating into the Criegee intermediates.