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2.
J Autism Dev Disord ; 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36357551

RESUMO

This study aims to evaluate the video modeling technique during the dental appointment. A blinded randomized clinical trial was composed of 2 groups, consisting of 20 autistic children (4 to 12 years) in each group: control (did not watch the video before the consultation) and intervention (watched the video before the consultation). The primary outcome was the mean number of visits to perform a dental appointment. The number of consultations was analyzed by T-test or Mann-Whitney test. The results showed that the mean number of consultations in the intervention group was 1.5 (± 1.53) and in the control group 2 (± 1.77) (p ≤ 0.05). The video modeling technique can be effective in minimizing the number of dental consultations in autistic children.

4.
Autops Case Rep ; 10(4): e2020210, 2020 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-33344325

RESUMO

Chronic infection by hepatitis C virus (HCV) can lead not only to the development of hepatic cirrhosis, but also to the emergence of extra-hepatic manifestations (EHMs), such as oral lichen planus (OLP). Here, we describe a clinical presentation of massive, erosive OLP in an HCV-positive patient whose clinical management was difficult. Full remission was achieved after sustained virological response by using direct-acting anti-retrovirals. This case report demonstrates not only the importance of diagnosing EHMs for identification of HCV infection, but also the importance of controlling it for management of OLP and EHMs.

5.
Oral Dis ; 25(4): 1100-1106, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30801844

RESUMO

OBJECTIVE: To verify whether there are differences between populations of CD8 + and FoxP3 + T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP-HCV) and lesions of idiopathic oral lichen planus (OLP-I). MATERIALS AND METHODS: A case-control study was performed using a convenience sample of 11 paraffin-embedded tissue blocks of OLP-HCV and 19 of OLP-I. Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Immunohistochemistry was used to identify CD8 + and FoxP3 + T cells. The count of positive cells was compared between the two groups and correlated to clinical and demographic data (p < 0.05). RESULTS: There were no statistically significant differences in the distribution of CD8 + and FoxP3 + T cells regarding the inflammatory infiltrate in lesions of OLP-HCV and OLP-I. Atrophic/erosive lesions showed a higher relationship between counts of CD8/FoxP3 T cells per mm2 (p = 0.018) and counts of CD8 + T cells per mm2 (p = 0.034) in OLP-HCV group compared to OLP-I group. CONCLUSION: Overall, no difference was found between cell populations in the lesions of OLP-HCV and OLP-I. However, atrophic/erosive lesions of OLP-HCV had a higher amount of CD8 + T cells and lower FoxP3 expression.


Assuntos
Linfócitos T CD8-Positivos/patologia , Fatores de Transcrição Forkhead , Líquen Plano Bucal/metabolismo , Mucosa Bucal/patologia , Linfócitos T Reguladores/metabolismo , Linfócitos T Reguladores/patologia , Adulto , Idoso , Estudos de Casos e Controles , Hepatite C Crônica/complicações , Hepatite C Crônica/imunologia , Humanos , Inflamação/metabolismo , Inflamação/patologia , Líquen Plano Bucal/patologia , Líquen Plano Bucal/virologia , Pessoa de Meia-Idade
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