Detection and typization of HPV genotypes in subjects with oral and upper respiratory tract lesions, Milan, Italy.

BACKGROUND: Oral human papillomavirus (HPV) is common among healthy individuals but causes and implications of persistent infections are under evaluation in the pathogenesis of head and neck neoplasms. METHODS: This was a retrospective study evaluating the prevalence of high-risk (HR), probable HR and low-risk (LR) HPV types in patients reporting signs/symptoms of oral and upper respiratory tract lesions. Individuals attending between 2019 and 2022 a University Hospital in Milan, Italy, with risk factors for HPV (unprotected oral sex and/or previous documentation of HPV infection in oral and upper respiratory tract and/or another anatomical site) were included. RESULTS: Fourteen out of 110 (12.7%) individuals tested positive for HPV DNA. The prevalence of HR-HPV and LR-HPV was 3.6% (4/110) and 9.1% (10/110), respectively. No probable/possible HR-HPV was detected. Specifically, 10/110 (9.1%) were diagnosed with 1 LR-HPV genotype, 3/110 (2.7%) were infected with 1 HR-HPV and 1/110 had 3 concomitant HR-HPV types. HPV 16 (2.7%, 3/110) and 6 (4.5%, 5/110) were the most common HR and LR types, respectively. One patient positive for HPV 16, 33 and 35 was diagnosed with cancer at the base of the tongue. Two individuals among those who tested positive for HPV DNA reported previous HPV vaccination. CONCLUSIONS: Our data, in line with observations from previous prevalence studies, support the potential role of HPV in head and neck neoplasms. HPV DNA testing should be performed in patients presenting lesions in oral/respiratory tracts and risk factors for HPV. Improvement in HPV vaccination coverage is warranted.

What is hiding behind the rainbow plot? The gender ideology and LGBTQ+ lobby conspiracies (GILC) scale.

Previous literature on conspiracy beliefs has an important gap, as it has almost completely excluded conspiracy beliefs relating to LGBTQ+ people. The purpose of the present research was to develop and validate a specific tool to measure the Gender Ideology and LGBTQ+ Lobby Conspiracies Beliefs: the GILC scale. Two independent data collections (Ntot = 1.908) were run involving both heterosexual and gay, lesbian and bisexual people. We expected a mono-factorial structure of the tool, with high levels of internal reliability, invariant by respondents' gender, sexual orientation and previous knowledge or hearsay of gender ideology. Furthermore, we expected that GILC scale manages to measure a differentiated construct: (a) compared to other specific and general conspiracy contents; (b) compared to a generic disposition to engage in conspiratorial mentality; (c) compared to existing measures of sexual prejudice, stereotypes and negative attitudes towards sexual minority people. In relation to criterion validity, we expected that several psychosocial and socio-political ideology variables (i.e. RWA and SDO), would associate with high levels in GILC scale. The results confirmed our expectations, showing that GILC scale is a short tool which include nine items with a mono-factorial structure and with excellent psychometric properties. Limitations and further research directions are discussed.

Gay, Lesbian, and Bisexual (LGB) peoples' leadership self-effectiveness: The roles of internalized sexual stigma, LGB positive identity, and traditional masculinity.

Grounded in the theoretical frameworks of the minority stress model and the model of positive identity in sexual minority people, the current research contributes to fill a gap in the previous literature, investigating the relationships among leadership self-effectiveness, internalized sexual stigma, positive identity, and adherence to traditional masculinity of gay, lesbian, and bisexual (LGB) individuals. Through a correlational study (N = 449), we collected data from 229 gay/bisexual men (51%) and 220 lesbian/bisexual women (49%). We hypothesized that lower internalized sexual stigma, higher LGB positive identity, and higher adherence to traditional masculinity were associated to higher self-perceived effectiveness. The interactive relationships among the variables, including participants' gender, were investigated from an exploratory perspective. The hypotheses were tested through two moderated regression models and the results confirmed that participants with lower internalized sexual stigma and higher LGB positive identity were more likely to perceive themselves as potential effective leaders. Also, the results showed a significant interaction between participants' gender and traditional masculinity score suggesting that high adherence to traditional masculinity was a significant predictor of self-perceived effectiveness only for gay/bisexual men, but not for lesbian/bisexual women. This research contributes to provide both confirmation and novel insights into the key role of relevant factors impacting on LGB people's leadership self-effectiveness, which might contribute to preserve the gay glass ceiling effect. The presence of antidiscrimination policies in organizations not only might reduce reports of discrimination but also enhance LGB employees' positive sense of self, which is a critical aspect to emerge as a leader.

Masculinity and Leadership Effectiveness (Self-)Perceptions: The Case of Lesbian Leaders.

In line with the gay glass ceiling effect, sexual minorities are often target of discrimination within work-related contexts, thus potentially undermining their wellbeing at work. For gay men, discrimination may partially be attributed to gay men's stereotypical feminine perception, which does not fit with the stereotypically masculine traits required for leadership positions. Yet, when considering lesbian women, the masculine stereotypical view associated with them may come to represent an advantage in work-related contexts, especially when compared to heterosexual women. In Study 1, N = 303 heterosexual participants rated a lesbian vs. a heterosexual woman as a job candidate on stereotypical gender (masculine vs. feminine) traits as well as leadership effectiveness. Results showed that being lesbian was associated with higher levels of masculinity (but not femininity), which in turn was related to high leadership effectiveness. In Study 2, N = 268 lesbian and heterosexual women rated themselves on the same measures. Results showed that both groups associated masculine traits with enhanced leadership effectiveness. These studies provide a better comprehension regarding how lesbian women may be perceived in work-related contexts and shed light on the role played by gender stereotypical perceptions in shaping both heterosexual and lesbian perceptions of leadership effectiveness.

Expectations about the "Natural Order of Things" and Conspiracy Beliefs about COVID-19.

The COVID-19 pandemic represents an event that unsettled the social and economic life of many people. When individuals are faced with shocking events, they may need to find plausible explanations for such events to restore control and make sense of reality. The adoption of conspiracy beliefs may represent a functional strategy for this purpose. The present study investigated whether the endorsement of conspiracy beliefs may be associated with the degree to which an upsetting event (i.e., the COVID-19 pandemic) is perceived as incoherent with individuals' general set of expectations about the world functioning (i.e., the natural order of things). Analyzing data from a community sample of 565 Italian participants, a path analysis model highlighted a mediation pattern where the natural order of things was negatively related to the adoption of conspiracy beliefs and, thus, was indirectly and positively related to support for the norms aimed at containing the spread of COVID-19, feelings of guilt about neglecting such norms, and intentions to be compliant with COVID-19 vaccination. Moreover, the natural order of things was indirectly and negatively related to attitudes focused on economic issues rather than public health and to negative attitudes towards COVID-19 vaccines through reduced beliefs in conspiracies.

Conspiracy beliefs of Italian voters for populist parties: The moderated mediational role of political interest and ideological attitudes.

Grounded in the theoretical framework of the dual-process motivational model of ideology and politics, we investigated the mediational role of RWA and SDO on the relationship between voting for populist parties and conspiracy beliefs; the moderation of political interest was also explored. Collapsing different convenience samples gathered after the European election (2014/2015) and the General National Election (2018/2019) allowed us to analyse two datasets (Study 1, n = 4141; Study 2, n = 2301). We hypothesised that populist voters would report higher conspiracy beliefs, RWA, and SDO, compared to non-populist voters and abstainers, and that populist voters would report more conspiracy beliefs through indirect pathways running through RWA and SDO. Furthermore, we hypothesised that such direct and indirect associations would be stronger for individuals with high rather than low political interest. Analyses of variance and moderated mediation models mostly confirmed our expectations, although RWA, and not SDO, mediated the relationships in the expected directions.

A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect.

We conducted a preregistered multilaboratory project (k = 36; N = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the paradigmatic replication approach. Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result (d = 0.06). Confirmatory Bayesian meta-analyses using an informed-prior hypothesis (δ = 0.30, SD = 0.15) found that the data were 4 times more likely under the null than the alternative hypothesis. Hence, preregistered analyses did not find evidence for a depletion effect. Exploratory analyses on the full sample (i.e., ignoring exclusion criteria) found a statistically significant effect (d = 0.08); Bayesian analyses showed that the data were about equally likely under the null and informed-prior hypotheses. Exploratory moderator tests suggested that the depletion effect was larger for participants who reported more fatigue but was not moderated by trait self-control, willpower beliefs, or action orientation.

A Multilab Replication of the Ego Depletion Effect.

There is an active debate regarding whether the ego depletion effect is real. A recent preregistered experiment with the Stroop task as the depleting task and the antisaccade task as the outcome task found a medium-level effect size. In the current research, we conducted a preregistered multilab replication of that experiment. Data from 12 labs across the globe (N = 1,775) revealed a small and significant ego depletion effect, d = 0.10. After excluding participants who might have responded randomly during the outcome task, the effect size increased to d = 0.16. By adding an informative, unbiased data point to the literature, our findings contribute to clarifying the existence, size, and generality of ego depletion.

Being mindful in the tax context in Italy: Examining whether and how mindfulness relates with tax evasion intentions and support for tax progressivity.

Two studies explored whether and how mindfulness relates with citizens' tax evasion intentions and support for progressive tax rates. Based on theoretical and empirical grounds, in Study 1 (N = 1,175) we proposed that mindfulness would be negatively related with tax evasion intentions through decreased social dominance orientation. Drawing on Duckitt's dual-process motivational model, in Study 2 (N = 722) we proposed that mindfulness would be positively related with support for progressive taxation through the mediation of lower competitive-jungle beliefs, and then lower social dominance orientation. Instead, we did not expect to find mediation of the link between mindfulness and support for progressive taxation through dangerous-world beliefs and right-wing authoritarianism. These studies inform about the motivational pathways through which mindfulness relates with tax evasion intentions and support for progressive taxation.

Can moral convictions against gender inequality overpower system justification effects? Examining the interaction between moral conviction and system justification.

It has been shown that disadvantaged groups who endorse system-justifying beliefs tend to internalize their state of inferiority by expressing ingroup derogation and opposing collective action for change. In the present research, we recruited women - as disadvantaged group - from different countries (the United States, the United Kingdom, Italy) and examined whether their moral conviction against gender inequality, as an absolute stance that does not tolerate any violation, may interact with and overpower system-justifying beliefs. Results from three studies provided support for our hypotheses. First, when women held strong moral conviction, they expressed higher identification with their disadvantaged ingroup and, in turn, higher collective action intentions, independent of system-justifying beliefs. Second, when women held weak moral conviction, higher system-justifying beliefs reduced women's ingroup identification and, in turn, undermined their collective action intentions. This support is found across different contexts of gender inequality (the gender leadership gap, the gender pay gap, and the gender power imbalance), using different methodological approaches (online survey, online experiment, laboratory experiment). Implications, limits, and future directions are discussed.

Is Covid-19 a natural event? Covid-19 pandemic and conspiracy beliefs.

In this paper, antecedents and consequences of conspiracy beliefs are investigated in the context of the COVID-19 pandemic in Italy. 618 individuals residing in different geographical area of Italy participated in the study. We found that perceived mortality rate of COVID-19 is positively associated with adherence to conspiracy beliefs and, in turn, with negative outcomes such as: (a) a reduced support for the measures taken to deal with the pandemic emergency, (b) a weaker feeling of guilt for the violation of anti-COVID-19 government rules, and (c) a stronger utilitarian stance which prioritizes economic over health-related outcomes of lockdown. Also, framing pandemic within the "natural order of things" - fundamental and implicit expectations concerning how life and the world should function - was expected to moderate the relationship between perceived mortality rate and conspiracy beliefs: we found this relationship to be weaker when people believe that pandemic falls into the "natural order of things".

Embrace the leadership challenge: The role of Gay men's internalized sexual stigma on the evaluation of others' leadership and one's own.

Grounded in the framework of the gay glass ceiling, the current research investigated the effect of gay men's internalized sexual stigma (ISS) on both the perceived effectiveness of other gay men's leadership and on their self-perceived leadership effectiveness and their intention to apply to a leadership position. In three studies (N = 402), we manipulated either the leader's sexual orientation (SO) (study 1), or his adherence to traditional gender roles (TGR) (study 2), or participants' fictitious masculinity score (study 3). Our hypotheses were as follows: the leader's SO and TGR would moderate the association of gay participants' ISS with their positive attitudes towards the leader and with his leadership effectiveness; and gay participants' masculinity threat would moderate the association of their ISS with their intention to apply to a leadership position, and with their self-perceived effectiveness as potential leaders. Moderated regression analyses showed that: participants reported a more positive attitude towards a gay man (vs. heterosexual) as leader only when they had low - and not high - ISS; participants with high (vs. low) ISS perceived the masculine gay leader as more effective than the feminine gay leader; under masculinity threat, participants with high (vs. low) ISS showed less intention to apply to a leadership position. These studies provide both confirmation and novel insights into the key role of internalized sexual stigma and traditional gender roles. Indeed, these factors can strengthen and perpetuate the gay glass ceiling effect.

Support for discriminatory behaviours against immigrants in Italy: Perceived threat and positive beliefs mediate the effect of contact with immigrants.

The present study aimed at investigating whether the effects of intergroup contact on support for discriminatory behaviours against immigrants was mediated by perceived threat from immigrants and positive beliefs toward immigrants. Using data from the Italian national survey on "Discrimination by Gender, Sexual Orientation and Ethnic Origin," which followed a multi-stage stratified cluster sampling procedure, a representative sample of 5509 Italian residents (53.4% women), aged 18 to 74 years, participated. Findings showed that contact with immigrants was negatively related to perceived threat, and positively related to positive beliefs toward immigrants. Mediational analysis conducted by structural equation modelling, indicated that support for discriminatory behaviours was positively associated with perceived threat, and negatively associated with positive beliefs toward immigrants. Both variables together mediated the relationship between contact with immigrants and support for discriminatory behaviours against immigrants; individually, indirect relationships were also significant. To promote interaction between natives and immigrants by reducing the perceived threat and strengthening positive beliefs toward immigrants might lessen support for discriminatory behaviours against immigrants.

"Keeping in mind the gender stereotype": the role of need for closure in the retrieval-induced forgetting of female managers' qualities.

The present research addressed the question of whether need for closure (NFC; Kruglanski in The psychology of closed mindedness, Psychology Press, New York, 2004) biases individuals' memory of female leaders. Merging research on role congruity theory of leadership (Koenig et al. in Psychol Bull 4:616-642, 2011. https://doi.org/10.1037/a0023557 ) and research on retrieval-induced forgetting (RIF, Anderson et al. in J Exp Psychol Learn Mem Cognit 20:1063-1087, 1994. https://doi.org/10.1037/0022-3514.65.5.861 ), we hypothesized and found that high-NFC participants show (1) a higher RIF of dimensions commonly associated with the leadership prototype (agentic/masculine) ascribed to female manager targets, when selectively retrieved dimensions commonly associated with the female prototype (communal/feminine) were ascribed to the same target; and (2) a lessened RIF of female stereotypical dimensions ascribed to female manager targets, when selectively retrieved prototypical leadership dimensions were ascribed to the same target. Overall, the present findings suggest that when faced with women leaders, high NfC enhances the accessibility of gender stereotype-congruent memories and reduces the accessibility of prototypical leadership ones, thus reducing the RIF of communal/feminine memories.

Neuromuscular Electrical Stimulation for Treatment-Refractory Chronic Dysphagia in Tube-Fed Patients: A Prospective Case Series.

OBJECTIVE: The aim of this study was to evaluate the role of neuromuscular electrical stimulation (NMES) in tube-fed patients with severe and chronic dysphagia refractory to traditional swallowing therapy (TT). PATIENTS AND METHODS: A total of 11 consecutive dysphagic patients with tube-dependent nutrition and who had not responded to 6 months of TT were enrolled. Each patient received NMES for 30 min and TT for 30 min, twice a day, 5 days per week for 4 weeks. In order to evaluate the swallowing impairment, each patient underwent a fiberoptic endoscopic examination of swallowing immediately before the beginning of the treatment, after 2 weeks and after 4 weeks. RESULTS: All enrolled patients managed to complete the swallowing treatment protocol for at least 2 weeks. After the 4-week treatment, 6 of 11 enrolled patients passed to a total oral diet with single or multiple consistencies despite specific food limitations or special preparation or compensation. Five patients, all affected by the most severe form of dysphagia, maintained tube-dependent nutrition. CONCLUSION: NMES as adjunctive treatment to TT may offer a new possibility for the management of tube-fed patients who are refractory to TT.

Reliability and validity of the Italian nose obstruction symptom evaluation (I-NOSE) scale.

The NOSE scale is a questionnaire assessing QOL related with nasal obstruction. The aim of this study was to culturally adapt the NOSE scale into Italian (I-NOSE). Prospective instrument validation study. Cross-cultural adaptation and validation were accomplished. Cronbach α was used to test internal consistency in 116 patients complaining nasal obstruction and 232 asymptomatic subjects. Pearson and ICC tests were used for test-retest reliability analysis. Normative data were gathered from the 232 asymptomatic subjects. Mann-Whitney test was used to compare the I-NOSE scores in patients and asymptomatic subjects and in 40 patients before and after septoplasty. I-NOSE scores obtained in 60 patients were correlated with rhinomanometric results and with the score of a visual analog scale (VAS) measuring the subjective sensation of nasal obstruction. Good internal consistency and good test-retest reliability were found. I-NOSE mean score of the normal cohort was 12.1 ± 13.2. Asymptomatic subjects scored lower than patients with nasal obstruction (p = 0.001). Positive correlations between I-NOSE scores and VAS and rhinomanometric results were found. The mean I-NOSE score improved from 64.4 ± 23.6 to 22.1 ± 13.5 after septoplasty (p < 0.001). The I-NOSE scale is a reliable, valid, self-administered, symptom-specific questionnaire; its application is recommended.

Multidimensional assessment of vocal changes in benign vocal fold lesions after voice therapy.

OBJECTIVE: To evaluate through a multidimensional protocol voice changes after voice therapy in patients with benign vocal fold lesions. METHODS: 65 consecutive patients affected by benign vocal fold lesions were enrolled. Depending on videolaryngostroboscopy the patients were divided into 3 groups: 23 patients with Reinke's oedema, 22 patients with vocal fold cysts and 20 patients with gelatinous polyp. Each subject received 10 voice therapy sessions and was evaluated, before and after voice therapy, through a multidimensional protocol including videolaryngostroboscopy, perception, acoustics, aerodynamics and self-rating by the patient. Data were compared using Wilcoxon signed-rank test. Kruskal-Wallis test was used to analyse the mean variation difference between the three groups of patients. Mann-Whitney test was used for post hoc analysis. RESULTS: Only in 11 cases videolaryngostroboscopy revealed an improvement of the initial pathology. However a significant improvement was observed in perceptual, acoustic and self-assessment ratings in the 3 groups of patients. In particular the parameters of G, R and A of the GIRBAS scale, and the noise to harmonic ratio, Jitter and shimmer scores improved after rehabilitation. A significant improvement of all the parameters of Voice Handicap Index after rehabilitation treatment was found. No significant difference among the three groups of patients was visible, except for self-assessment ratings. CONCLUSION: Voice therapy may provide a significant improvement in perceptual, acoustic and self-assessed voice quality in patients with benign glottal lesions. Utilization of voice therapy may allow some patients to avoid surgical intervention.