1.
Adv Exp Med Biol
; 195 Pt B: 177-83, 1986.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3020904
Assuntos
Floxuridina/farmacologia , Leucemia L1210/enzimologia , Nucleotidases/antagonistas & inibidores , 5'-Nucleotidase , Animais , Antimetabólitos Antineoplásicos , Biotransformação , Ciclo Celular/efeitos dos fármacos , DNA de Neoplasias/biossíntese , Fluoruracila/farmacologia , Camundongos , Pentosiltransferases/antagonistas & inibidores , Pirimidina Fosforilases , RNA Neoplásico/biossíntese , Timidilato Sintase/antagonistas & inibidores
2.
Br J Cancer
; 49(6): 739-44, 1984 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6234011
RESUMO
The mode of action of 5-fluorouracil (FUra) and 5-fluoro-2'-deoxyuridine (FdUrd) on L1210 leukaemia has been studied. It is shown that FUra and FdUrd follow different routes of metabolism and have different targets with respect to their cytotoxic activity. FUra is converted to 5-fluorouridine-5'triphosphate ( FUTP ), which is incorporated into nascent RNA. FdUrd is converted to 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP), which inhibits the de novo synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP). Conversion of FUra to FdUMP does occur, but this phenomenon does not contribute to the final cytotoxic effect. No conversion of FdUrd to FUra has been detected.