Niosomal entrapment improved the bactericidal properties of azithromycin against methicillin-resistant Staphylococcus aureus.

Aim: This study seeks to optimize niosomal formulations of azithromycin (AZ) and evaluate their activities against methicillin-resistant Staphylococcus aureus (MRSA). Methods: The thin-film hydration was used to prepare niosomes containing various molar ratios of span 60, cholesterol, dicetylphosphate and AZ. Formulation 5, with 5:1:1:1 molar ratio, was optimized based on entrapment efficiency. Solid state analyses and accelerated stability were carried out. The antibacterial properties against MRSA was determined by agar well diffusion method. Results: Physico-chemical characterization of formulation 5 confirmed successful encapsulation of AZ with slightly improved stability at 30°C for 6 months. Niosomal AZ at 0.1% is as effective as vancomycin in inhibiting the growth of MRSA. Conclusion: The antibacterial activities of AZ against MRSA is enhanced when encapsulated within niosomes.

This study seeks to prepare niosome formulations of azithromycin (AZ) and evaluate their activities against methicillin-resistant Staphylococcus aureus (MRSA). Methods: The thin-film hydration was used as the method to prepare niosomes containing various ratios of span 60, cholesterol, dicetylphosphate and AZ. Formulation 5 was chosen as the most ideal formulation. Solid state analyses and accelerated stability were carried out. The antibacterial properties against MRSA was determined by agar well diffusion method. Results: Physical and chemical characterization of formulation 5 confirmed successful encapsulation of AZ with slightly improved stability at 30°C for 6 months. Niosomal AZ at 0.1% is as effective as vancomycin in inhibiting the growth of MRSA. Conclusion: The antibacterial activities of AZ against MRSA is enhanced when encapsulated within niosomes.

Brinzolamide-loaded soft contact lens for ophthalmic delivery.

Aim: In this study, brinzolamide (BRZ) was loaded in balafilcon A silicone hydrogel soft contact lens to enhance delivery in glaucoma therapy. Materials & methods: BRZ-loaded soft contact lens was prepared by the soaking method with optimization of pH, temperature and concentration of drug loading solution. Results: At pH 7.4, loading temperature and concentration of 32°C and 3 mg/ml, respectively, enhanced drug loading capacity and release were observed. Diffusional experiments showed Higuchi model of release. BRZ loading brought no appreciable changes in the physical properties of soft contact lens, likewise, maintaining stability. Conclusion: The results demonstrated BRZ loading and delivery through silicone hydrogel soft contact lens which provides a potential alternative in glaucoma therapy.

Aim: In this study, brinzolamide (BRZ) was loaded in soft contact lens to improve drug delivery in glaucoma therapy. Materials & methods BRZ-loaded soft contact lens was prepared by the soaking method modifying pH, temperature and concentration of drug loading solution. Results: At pH 7.4, loading temperature and concentration of 32°C and 3 mg/ml, respectively, enhanced drug loading and release were observed. Diffusion is the main mechanism regulating drug release. BRZ loading brought no changes in the physical properties of soft contact lens, likewise, maintaining stability. Conclusion: The results demonstrated BRZ loading and delivery through soft contact lens which provides a potential alternative in glaucoma therapy.