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Expert Rev Anti Infect Ther ; 15(4): 351-359, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28002979

RESUMO

INTRODUCTION: Community-acquired pneumonia (CAP) continues to be associated with significant mortality and morbidity. As with other infectious diseases, in recent years there has been a marked increase in resistance to the antibiotics commonly used against the pathogens that cause CAP. Antimicrobial stewardship denotes coordinated interventions to improve and measure the appropriate use of antibiotics by encouraging the selection of optimal drug regimens. Areas covered: Several elements can be applied to antibiotic stewardship strategies for CAP in order to maintain or improve patient outcomes. In this regard, antibiotic de-escalation, duration of antibiotic treatment, adherence to CAP guidelines recommendations about empirical treatment, and switching from intravenous to oral antibiotic therapy may each be relevant in this context. Antimicrobial stewardship strategies, such as prospective audit with intervention and feedback, clinical pathways, and dedicated multidisciplinary teams, that have included some of these elements have demonstrated improvements in antimicrobial use for CAP without negatively affecting clinical outcomes. Expert commentary: Although there are a limited number of randomized clinical studies addressing antimicrobial stewardship strategies in CAP, there is evidence that antibiotic stewardship initiatives can be securely applied, providing benefits to both healthcare systems and patients.


Assuntos
Antibacterianos/uso terapêutico , Infecções Comunitárias Adquiridas/tratamento farmacológico , Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos , Pneumonia Bacteriana/tratamento farmacológico , Administração Intravenosa , Administração Oral , Infecções Comunitárias Adquiridas/microbiologia , Gerenciamento Clínico , Esquema de Medicação , Cálculos da Dosagem de Medicamento , Humanos , Pneumonia Bacteriana/microbiologia , Guias de Prática Clínica como Assunto
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