Effects of paddles and fins on front crawl kinematics, arm stroke efficiency, coordination, and estimated energy cost.

Paddles and fins are used in swimmers training with different objectives (e.g., increase propulsive areas of hands and feet, improve the feeling of water flow). These artificial modifications of the stroke might be viewed as external constraints of the stroke task, both will either disturb or facilitate swimming modalities, so the coaches should manipulate its use to extract benefits for performance. This study seeks to investigate the precise effects of wearing either paddles (PAD) or fins (FINS) vs. a no-equipment (NE) trial in three all-out front crawl exercises on swimmer kinematics, arm stroke efficiency (ηp), upper-limbs coordination patterns (Index of Coordination, IdC), and estimated energy cost (C). Eleven regional to national-level male swimmers participated in the study (age: 25.8 ± 5.5 years, body mass: 75.2 ± 5.5 kg, height: 177 ± 6.5 cm) and were recorded from both sides of the swimming pool to collect all variables. Repeated measures ANOVA and Bonferroni post hoc were used to compare the variables. Effects sizes were calculated. Time to cover the distance and velocity were higher in FINS swimming, with larger values of stroke length (SL) and lower kick amplitude in comparison to the other trials (PAD and NE). The use of FINS also modified the stroke phases durations by presenting significant lower propulsion time during the stroke in comparison to PAD or NE. Values of IdC were lower (IdC < -1%, so catch-up pattern of coordination) for FINS in comparison to NE. In terms of ηp, using PAD or FINS demonstrate higher arm stroke efficiency than swimming without equipment. Finally, C was significantly higher in FINS swimming in comparison to NE and PAD. From the present results, it should be noted that the use of equipment such as fins deeply modify the structure of the swimming stroke (from the performance-related parameters through the kinematics of both upper and lower limbs to the stroke efficiency and coordination pattern). So, using equipment should be appropriately scaled by the coaches to the objectives of the training session in swimming, and in emergent sports such as "SwimRun", paddles and fins must be viewed as tools to achieve higher velocities to cover a given distance.

[Castleman-like presentation of systemic lupus: About a case report]. / Présentation « Castleman-like ¼ de lupus systémique : à propos d'un cas.

INTRODUCTION: Castleman disease is a rare lymphoproliferation, which may mimic systemic lupus. Conversely, systemic lupus sometimes presents like an hematological malignancy. In these cases, a "Castleman-like" histology has been exceptionally described. OBSERVATION: A 55-year-old female treated by methotrexate for systemic lupus with skin and joint involvement presented weight loss, polyadenopathy and clinical signs of lupus flare. Biology showed pancytopenia, complement activation, and positive anti-DNA antibodies. PET/CT showed hypermetabolic polyadenopathy. The lymph node biopsy showed "Castleman-like" features. Treatment with corticosteroids and azathioprine resulted in complete remission. CONCLUSION: Systemic lupus and Castleman disease may share common clinical, biological, and histological features. The presence of specific elements of systemic lupus flare and the remission obtained by low-dose corticosteroids results in considering the diagnosis of Castleman-like systemic lupus and avoiding treatment intensification.

Van der Waals materials as dielectric layers for tailoring the near-field photonic response of surfaces.

Epsilon near-zero photonics and surface polariton nanophotonics have become major fields within optics, leading to unusual and enhanced light-matter interaction. Specific dielectric responses are required in both cases, which can be achieved, e.g., via operation near a material's electronic or phononic resonance. However, this condition restricts operation to a specific, narrow frequency range. It has been shown that using a thin dielectric layer can adjust the dielectric response of a surface and, therefore, the operating frequency for achieving specific photonic excitations. Here, we show that a surface's optical properties can be tuned via the deposition/transference of ultra-thin layered van der Waals (vdW) crystals, the thicknesses of which can easily be adjusted to provide the desired response. In particular, we experimentally and theoretically show that the surface phonon resonance of a silica surface can be tuned by ∼50 cm-1 through the simple deposition of nanometer-thick exfoliated flakes of black phosphorus. The surface properties were probed by infrared nanospectroscopy, and results show a close agreement with the theory. The black phosphorus-silica layered structure effectively acts as a surface with a tunable effective dielectric constant that presents an infrared response dependent on the black phosphorus thickness. In contrast, with a lower dielectric constant, hexagonal boron nitride does not significantly tune the silica surface phonon polariton. Our approach also applies to epsilon near-zero surfaces, as theoretically shown, and to polaritonic surfaces operating at other optical ranges.

Edge phonons in black phosphorus.

Black phosphorus has recently emerged as a new layered crystal that, due to its peculiar and anisotropic crystalline and electronic band structures, may have important applications in electronics, optoelectronics and photonics. Despite the fact that the edges of layered crystals host a range of singular properties whose characterization and exploitation are of utmost importance for device development, the edges of black phosphorus remain poorly characterized. In this work, the atomic structure and behaviour of phonons near different black phosphorus edges are experimentally and theoretically studied using Raman spectroscopy and density functional theory calculations. Polarized Raman results show the appearance of new modes at the edges of the sample, and their spectra depend on the atomic structure of the edges (zigzag or armchair). Theoretical simulations confirm that the new modes are due to edge phonon states that are forbidden in the bulk, and originated from the lattice termination rearrangements.

Ultrastructural characterization of fresh and cryopreserved in vivo produced ovine embryos.

Controlled slow freezing and vitrification have been successfully used for ovine embryo cryopreservation. Selection of embryos for transfer is based on stereomicroscopical embryo scoring after thawing, but the subjectivity inherent to this selection step has been demonstrated by ultrastructural studies of controlled slow frozen, in vivo produced ovine morulae and blastocysts. These studies have shown that certain abnormalities remain undetected by stereomicroscopy only. In the present study, using ovine in vivo produced morulae and blastocysts, we have studied the ultrastructural alterations induced by open pulled straw vitrification (OPS) and controlled slow freezing, compared stereomicroscopical embryo scoring with light microscopy evaluation of embryo's semithin sections, and related the ultrastructural cellular damage with the embryo classification by stereomicroscopical embryo scoring of embryos' and semithin section evaluation by light microscopy. The ultrastructural lesions found for OPS-vitrified and controlled slow frozen embryos were similar, independently of embryo stage. A significant higher number of grade 3 embryos was found at stereomicroscopical scoring after controlled slow freezing (P=0.02), and a significant higher number of grade 3 blastocysts was found at semithin sectioning after OPS vitrification (P=0.037). The extension of ultrastructural damage, especially of mitochondria and cytoskeleton, was related to the semithin classification but not to stereomicroscopical scoring at thawing. This suggests that semithin scoring is a useful tool for predicting ultrastructural lesions and new improvements in cryopreservation and thawing methods of ovine embryos are still warranted, including in the case of blastocysts cryopreserved by OPS vitrification.

The comparative prevalence of five ixodid tick species infesting cattle and goats in Maputo Province, Mozambique.

This study compares the prevalence of ixodid tick species on cattle and goats in Maputo Province. Adult ticks as well as the nymphs of three species, and only the adults of two species were collected from sets of five cattle at 21 localities throughout the province and compared with those collected from similar sets of goats at the same places. Amblyomma hebraeum adults and/or nymphs were present on cattle and on goats at all 21 localities, and 90 cattle and 22 goats were infested with adult ticks. Rhipicephalus (Boophilus) microplus adults and/or nymphs were collected from cattle at 20 and from goats at 15 localities, and 92 cattle and 34 goats were infested [Chi-square test (chi2), P<0.001]. The total length of several maturing female R. (Boophilus) microplus collected from cattle and goats exceeded 5 mm, indicating that they successfully engorge on both host species. Rhipicephalus appendiculatus adults and/or nymphs were present on cattle at 15 and on goats at 13 localities, but 28 cattle and only one goat were infested with adult ticks (chi2, P<0.001). Adult Rhipicephalus evertsi evertsi were recovered from cattle at 20 and from goats at 17 localities, and 74 cattle and 69 goats were infested. Adult Rhipicephalus simus were collected from cattle at 18 and from goats at 11 localities (Fisher's exact test, P=0.04), and 60 cattle and 14 goats were infested (chi2, P<0.001). These findings underscore the advisability of including goats in acaricide application programmes designed for the control of tick-borne diseases in cattle at the same locality.

Species composition and geographic distribution of ticks infesting cattle, goats and dogs in a temperate and in a subtropical region of south-east Africa.

The species and distribution of ticks infesting cattle, goats and dogs in the eastern region of the Eastern Cape Province, South Africa and Maputo Province, Mozambique were determined from collections made from these animals at 72 localities in the former region and 30 in the latter. Eleven ixodid and one argasid species were recovered in the Eastern Cape Province and 15 ixodid species in Maputo Province. The most common ticks infesting cattle and goats in both provinces were Amblyomma hebraeum, Rhipicephalus (Boophilus) microplus, Rhipicephalus appendiculatus and Rhipicephalus evertsi evertsi. The dominant species on dogs were Haemaphysalis elliptica and Rhipicephalus simus. The geographic distributions of the major species and some of the minor species in both regions were plotted. The partial or complete displacement of the indigenous tick Rhipicephalus (Boophilus) decoloratus by the introduced species R. (B.) microplus was a major feature of both surveys.

Ixodid ticks on dogs belonging to people in rural communities and villages in Maputo Province, Mozambique.

The species composition and geographic distribution of ixodid ticks infesting domestic dogs owned by people in rural communities and villages in Maputo Province was established by collecting ticks from dogs at each of 27 localities spread throughout the province. Ticks were collected from a total of 132 dogs, and nine species belonging to four genera were identified. One dog was infested with six species, three with five and 13 with four species. Haemaphysalis elliptica followed by Rhipicephalus simus were present on dogs at most localities, and their geographic distribution in Maputo Province has been mapped for the first time.

20-kW peak power all-fiber 1.57-microm source based on compression in air-core photonic bandgap fiber, its frequency doubling, and broadband generation from 430 to 1450 nm.

We demonstrate an ultrashort all-fiber-integrated chirped-pulse amplification system yielding 1-ps pulses with 20 kW of peak power. 40-ps initial pulses generated by an externally modulated laser diode are chirped by self-phase modulation in a conventional fiber, amplified, and compressed in 110 m of air-core photonic bandgap fiber. The compressed pulses are frequency doubled in a periodically poled KTP crystal with up to 48% efficiency and applied to supercontinuum generation in a holey fiber, resulting in a high-power uniform continuum that stretches from 430 to 1450 nm.

Chirped pulse Raman amplification with compression in air-core photonic bandgap fiber.

An all-fiber chirped pulse amplification scheme based on Raman amplifiers and compression in air-core photonic bandgap fiber is demonstrated for the first time. Pulse chirping was achieved through nonlinear propagation in the amplifiers and a net compression factor of 53 was achieved. Output pulses presented sub-picosecond durations. Output peak powers approached 1 kW, being 3 orders of magnitude higher than those obtainable with Raman amplifiers without the chirped pulse amplification setup. The demonstrated scheme may instigate the use of fiber Raman amplifiers outside optical communications, as it is simple, robust, and may be built to operate at virtually any optical wavelength.

All-fiber format compression of frequency chirped pulses in air-guiding photonic crystal fibers.

Air-cored, photonic band-gap crystal fibers exhibiting low nonlinearity and anomalous chromatic dispersion in spectral ranges inaccessible to conventional fibers can be used in the realization of all-fiber-format pulse compressors with unprecedented peak powers and wavelength diversity. Linear compression of inherently chirped and prestretched pulses by factors ranging from 20 to 80 around 1.0 and 1.5 microm have allowed generation of pulses as short as 163 fs. The results show that totally integrated femtosecond fiber laser sources can be realized throughout the visible and near-infrared and point to the possibility of megawatt peak and tens of watt average in-fiber power levels.

Continuous-wave, totally fiber integrated optical parametric oscillator using holey fiber.

We present, for the first time to our knowledge, a cw, all-fiber optical parametric oscillator that uses a holey fiber. The oscillator operates at 1.55 microns and can yield an oscillating parametric signal that consists of a single line with a 30-dB extinction ratio and a 10-pm linewidth or that consists of multiple lines. In addition to the signal and the idler, five other pairs of spectral lines can be observed that are due to multiple parametric interactions. The source reaches threshold for a pump power of 1.28 W and saturates for pump powers in excess of approximately 1.6 W.

Multi-kilowatt, all-fiber integrated chirped-pulse amplification system yielding 40x pulse compression using air-core fiber and conventional erbium-doped fiber amplifier.

We present a totally fiber integrated chirped-pulse amplification system using air-core photonic bandgap fiber and a conventional erbium-doped fiber amplifier. ~40-ps input pulses, generated in a Mach-Zehnder modulator, were stretched and spectrally broadened in a dispersion-shifted fiber before being amplified and subsequently compressed in 10 m of anomalously-dispersive photonic bandgap fiber to yield ~960 fs pulses. The system gives multi-kilowatt peak powers while the amplifier nonlinearity threshold is as low as ~150 W. Higher peak powers could be obtained by the use of an amplifier with higher nonlinearity threshold.

Short-pulse, all-fiber, Raman laser with dispersion compensation in a holey fiber.

The use of Raman gain in conventional fiber followed by dispersion compensation in a holey fiber in a synchronously pumped laser configuration allowed compression by a factor of 8.5 of output pulses at a selected wavelength with respect to the pump pulses. We obtained 2-ps output pulses at 1.14 microm from a totally fiber-integrated laser pumped with 17-ps pulses at 1 microm. Higher pulse compression should be possible with nonlinear chirp compensation. Ultrashort-pulse, all-fiber Raman lasers at wavelengths shorter than 1.3 microm are feasible.

Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD.

BACKGROUND: The pathophysiology of chronic obstructive pulmonary disease (COPD) features pulmonary inflammation with a predominant alveolar macrophage involvement. Bronchoalveolar macrophages from patients with COPD release increased amounts of inflammatory cytokines in vitro, an effect that is not inhibited by the glucocorticosteroid dexamethasone. Resveratrol (3,5,4'-trihydroxystilbene) is a component of red wine extract that has anti-inflammatory and antioxidant properties. A study was undertaken to determine whether or not resveratrol would inhibit cytokine release in vitro by alveolar macrophages from patients with COPD. METHODS: Alveolar macrophages were isolated from bronchoalveolar lavage (BAL) fluid from cigarette smokers and from patients with COPD (n=15 per group). The macrophages were stimulated with either interleukin (IL)-1beta or cigarette smoke media (CSM) to release IL-8 and granulocyte macrophage-colony stimulating factor (GM-CSF). The effect of resveratrol was examined on both basal and stimulated cytokine release. RESULTS: Resveratrol inhibited basal release of IL-8 in smokers and patients with COPD by 94% and 88% respectively, and inhibited GM-CSF release by 79% and 76% respectively. Resveratrol also inhibited stimulated cytokine release. Resveratrol reduced IL-1beta stimulated IL-8 and GM-CSF release in both smokers and COPD patients to below basal levels. In addition, resveratrol inhibited CSM stimulated IL-8 release by 61% and 51% respectively in smokers and COPD patients, and inhibited GM-CSF release by 49% for both subject groups. CONCLUSIONS: Resveratrol inhibits inflammatory cytokine release from alveolar macrophages in COPD. Resveratrol or similar compounds may be effective pharmacotherapy for macrophage pathophysiology in COPD.

All-fiber chirped pulse amplification using highly-dispersive air-core photonic bandgap fiber.

We show, for the first time to our knowledge, all-fiber chirped pulse amplification using an air-core photonic bandgap fiber. Pulses from a wavelength- and duration-tunable femtosecond/picosecond source at 10 GHz were dispersed in 100 m of dispersion compensating fiber before being amplified in an erbium-doped fiber amplifier and subsequently recompressed in 10 m of the anomalously dispersive photonic bandgap fiber. Pulses as short as 1.1 ps were obtained. As air-core fibers present negligible nonlinearity, the presented configuration can potentially be used to obtain ultra-high pulse peak powers. A study of the air-core fiber dispersion and dispersion slope is also presented.

Low-threshold self-induced modulational instability ring laser in highly nonlinear fiber yielding a continuous-wave 262-GHz soliton train.

Modulational instability (MI) is employed in a self-induced ring cavity configuration based on highly nonlinear dispersion-shifted fiber (HNL DSF) and an erbium-doped fiber amplifier to generate a continuous-wave 262-GHz train of 365-fs optical solitons. The laser operates around 1540 nm, with an average output power of 15 mW. MI is achieved at a low threshold as a result of low average cavity dispersion and high fiber nonlinearity. It is shown that, because of the normal dispersion of the HNL DSF, the solitons exist in the average soliton regime.

4x repetition-rate multiplication and Raman compression of pulses in the same optical fiber.

A 21.7-km nonzero dispersion-shifted fiber was used to obtain 4x multiplication of the repetition rate of a 20-GHz train of 4.2-ps optical pulses through the temporal Talbot effect. Raman compression in the same fiber shortened and developed the pulses into 2.0-ps solitons and resulted in a lower duty cycle. It is shown that the linear Talbot effect and nonlinear Raman compression occurred in different sections of the fiber, the lengths of which could be varied through adjustments in the input pulse power.

Copropagating and counterpropagating pumps in second-order- pumped discrete fiber Raman amplifiers.

The gains and noise figures of discrete second-order-pumped fiber Raman amplifiers utilizing copropagating and counterpropagating pump configurations were experimentally obtained, and the gain results were compared with computer simulations. It was found that the additional gain that is due to second-order Raman pumping is larger for the copropagating pumps than for the counterpropagating pumps, in agreement with simulations. In contrast to distributed second-order-pumped fiber Raman amplifiers, a slight increase in noise figure, by as much as ~1 dB was observed relative to the single-pump scheme. However, the advantages of second-order pumping in discrete amplifiers include greater flexibility in design of the gain distribution along the fiber and the ability to spectrally distribute the pump powers to avoid undesired nonlinear effects.

Continuous-wave-pumped Raman-assisted fiber optical parametric amplifier and wavelength converter in conventional dispersion-shifted fiber.

We present a continuous-wave-pumped fiber optical parametric amplifier, operating near 1539 nm in conventional dispersion-shifted fiber, with maximum on-off gain and wavelength-conversion efficiency of 13.7 and 13.1 dB, respectively. In addition, we show a novel configuration based on Raman amplification assistance in the parametric gain fiber that further increases the gain and wavelength-conversion efficiencies to 16.7 and 16.2 dB, respectively.