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1.
Exp Eye Res ; 245: 109964, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38851478

RESUMO

To prevent ocular pathologies, new generation of dietary supplements have been commercially available. They consist of nutritional supplement mixing components known to provide antioxidative properties, such as unsaturated fatty acid, resveratrol or flavonoids. However, to date, few data evaluating the impact of a mixture mainly composed of those components (Nutrof Total®) on the retina are available. Only one in-vivo preclinical study demonstrated that dietary supplementation (DS) prevents the retina from light-induced retinal degeneration; and only one in-vitro study on Müller cells culture showed that glutamate metabolism cycle was key in oxidative stress response. Therefore, we raised the question about the in-vivo effect of DS on glutamate metabolism in the retina. Herein, we showed that the dietary supplementation promotes in-vivo increase of retinal glutamine amount through a higher glutamine synthesis as observed in-vitro on Muller cells. Therefore, we can suggest that the promotion of glutamine synthesis is part of the protective effect of DS against retinal degeneration, acting as a preconditioning mechanism against retinal degeneration.


Assuntos
Antioxidantes , Suplementos Nutricionais , Ácidos Graxos Ômega-3 , Glutamina , Retina , Degeneração Retiniana , Glutamina/metabolismo , Animais , Antioxidantes/farmacologia , Ácidos Graxos Ômega-3/administração & dosagem , Degeneração Retiniana/metabolismo , Degeneração Retiniana/prevenção & controle , Retina/metabolismo , Retina/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Células Cultivadas , Células Ependimogliais/metabolismo , Células Ependimogliais/efeitos dos fármacos , Masculino , Ratos , Modelos Animais de Doenças
2.
HLA ; 103(4): e15470, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38566403

RESUMO

The new HLA-DPA1*01:182 allele differs from HLA-DPA1*01:03:01:04 by a single mismatch in exon 4.


Assuntos
Medula Óssea , Cadeias alfa de HLA-DP , Humanos , Alelos , Brasil , Teste de Histocompatibilidade
3.
HLA ; 103(2): e15407, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38372613

RESUMO

We identified two new HLA-DRB3 alleles in Brazilian individuals using next generation sequencing.


Assuntos
Medula Óssea , Humanos , Cadeias HLA-DRB3 , Alelos , Brasil
4.
HLA ; 103(1): e15343, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38193612

RESUMO

HLA-A*68:190:02 differs from A*68:190:01 by a single synonymous nucleotide change in exon 2.


Assuntos
Medula Óssea , Humanos , Alelos , Brasil , Éxons/genética
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