The inferior fronto-occipital fasciculus correlates with early precursors of mathematics and reading before the start of formal schooling.

Diffusion-weighted imaging studies in preschoolers have almost exclusively been done in the field of reading. As a result, virtually nothing is known about white matter tracts associated with individual differences in mathematics at this age. Studying the preschoolers' brain is crucial because it allows us to identify individual differences in brain anatomy without influences of formal mathematics and reading instruction. To fill this gap, we investigated for the first time before the start of formal school entry the associations between white matter tracts and precursors of mathematics and reading simultaneously. We also investigated whether these associations were specific to mathematics and to reading, or not. We focused on four bilateral white matter tracts (arcuate fasciculus (direct, anterior), inferior fronto-occipital fasciculus, inferior longitudinal fasciculus), which have been previously correlated with mathematical performance in older children and with reading performance in children of a similar age as the current study. Participants were 56 5-year-old children (Mage = 67 months; SD = 1.8), none of which received formal instruction. Our results showed an association between the bilateral inferior fronto-occipital fasciculus and precursors of mathematics (numerical ordering, numeral knowledge) and reading (phonological awareness, letter knowledge). Follow-up regression analyses revealed that the associations found with the inferior fronto-occipital fasciculus were neither specific to mathematics nor specific to reading. These findings suggest that, already before the start of formal schooling, the inferior fronto-occipital fasciculus might be related to the neural overlap between mathematics and reading. This overlap potentially reflects one of their many shared mechanisms, such as the reliance on phonological codes or the processing of visual symbols, and these mechanisms should be exploited in future studies.

A dashboard for the evaluation of the effect of school closures on wellbeing of children and parents.

BACKGROUND: We present a dashboard for the evaluation of the impact of school closures on children and parents during the first wave of the COVID pandemic in 2020 on the various components of wellbeing. METHODS: Starting from an explorative literature search by a team of experts from diverse fields (e.g., epidemiology, virology, psychology, education, sociology), we developed a dashboard that allows for the quick evaluation of the general effect of school closures on various indicators of well-being in different groups and for the quality of the available research, at a time where a crisis is ongoing. RESULTS: It is concluded that there is evidence that the school closures reduced the transmission of COVID in the first wave in springtime 2020. Nevertheless, a multitude of studies show that the school closures also had a negative impact on different components of wellbeing such as academic achievement, time spent on learning and mental health. Furthermore, the school closures affected not only the children and adolescents, but also the parents that were forced to provide more childcare and help with schoolwork. Longitudinal studies on large representative samples with repeated assessments of wellbeing are necessary to understand the long-term effects of the school closures. CONCLUSIONS: The dashboard provides a first visual overview of the effects of school closures on wellbeing, and can serve as the basis for a future more systematic review and meta-analysis of the effects of school closures on wellbeing. It can be considered as a paradigm for rapid obtention of scientific evidence, during a quickly unfolding crisis, also in view of underpinning policy advice.

Longitudinal pathways of numerical abilities in preschool: Cognitive and environmental correlates and relation to primary school mathematics achievement.

Children start preschool with large individual differences in their early numerical abilities. Little is known about the importance of heterogeneous patterns that exist within these individual differences. A person-centered analytic approach might be helpful to unravel these patterns and the cognitive and environmental factors that are associated with them. We applied a person-centered approach to a 5-year longitudinal study (N = 410, 213 boys) conducted in Belgium from preschool to grade 3. Preschoolers (Mage = 58.14 months, SDage = 3.51) were selected to represent the full range of socioeconomic backgrounds. We examined via Latent Profile Analysis the heterogeneous patterns that exist in preschoolers' early numerical development using measures of counting, numeral identification, comparison, ordering, and arithmetic abilities. We investigated the association between the derived numerical ability pathways, general cognitive factors (working memory, language, spatial ability) and the home math environment. We also evaluated the relation of these early numerical ability pathways to later mathematics achievement in grade 1 and 3. Four longitudinal pathways emerged: a low (15%), below-average (28%), above-average (44%), and a high numerical ability pathway (13%). Differences between the four pathways were mostly quantitative. Most of the general cognitive factors contributed to pathway membership, whereas the home math environment and socioeconomic status (SES) did not. The pathways differed in mathematics achievement in grade 1 and 3, and most of these differences remained when the covariates were considered. The results highlight the heterogeneity that is already present in preschoolers' numerical abilities and their predictive value for subsequent mathematics achievement. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Aging effects and feasibility of statistical learning tasks across modalities.

Knowledge on statistical learning (SL) in healthy elderly is scarce. Theoretically, it is not clear whether aging affects modality-specific and/or domain-general learning mechanisms. Practically, there is a lack of research on simplified SL tasks, which would ease the burden of testing in clinical populations. Against this background, we conducted two experiments across three modalities (auditory, visual and visuomotor) in a total of 93 younger and older adults. In Experiment 1, SL was induced in all modalities. Aging effects appeared in the tasks relying on an explicit posttest to assess SL. We hypothesize that declines in domain-general processes that predominantly modulate explicit learning mechanisms underlie these aging effects. In Experiment 2, more feasible tasks were developed for which the level of SL was maintained in all modalities, except the auditory modality. These tasks are more likely to successfully measure SL in elderly (patient) populations in which task demands can be problematic.

Subtraction by addition in young multi-digit subtraction learners: A choice/no-choice study.

When solving subtraction problems such as 83-46, children use the direct subtraction (DS) strategy (e.g., 83 - 40 = 43, 43 - 6 = 37) or the subtraction by addition (SBA) strategy (e.g., 46 + 4 = 50, 50 + 30 = 80, 80 + 3 = 83, so the answer is 4 + 30 + 3 = 37). This study is the first to use the choice/no-choice method to examine DS and SBA use in third-graders (8- and 9-year-olds) with varying mathematical achievement levels. All children (N = 66) solved a series of small difference subtractions (e.g., 72 - 64) and large difference subtractions (e.g., 94 - 8) in one choice condition (choice between DS and SBA) and two no-choice conditions (obligatory use of either DS or SBA). Results showed that, although only the DS strategy was taught to these children, in the choice condition nearly half the children already made use of the SBA strategy and that SBA was used on one in five subtractions. Whereas DS was the fastest strategy on large difference items, interestingly, children achieved a similar level of accuracy with the SBA strategy compared with DS. Finally, 1 in 5 children made problem-based adaptive strategy choices, and children were generally adaptive to their individual strategy speed. This study clearly demonstrates the nascent use of SBA in third-graders and provides evidence for the plea to introduce SBA as an alternative to DS already in the lower grades of elementary school.

Counting many as one: Young children can understand sets as units except when counting.

Young children frequently make a peculiar counting mistake. When asked to count units that are sets of multiple items, such as the number of families at a party, they often count discrete items (i.e., individual people) rather than the number of sets (i.e., families). One explanation concerns children's incomplete understanding of what constitutes a unit, resulting in a preference for discrete items. Here we demonstrate that children's incomplete understanding of counting also plays a role. In an experiment with 4- and 5-year-old children (N = 43), we found that even if children are able to name sets, group items into sets, and create one-to-one correspondences with sets, many children are nevertheless unable to count sets as units. We conclude that a nascent understanding of the abstraction principle of counting is also a cause of some children's counting errors.

Early white matter connectivity and plasticity in post stroke aphasia recovery.

A disruption of white matter connectivity is negatively associated with language (recovery) in patients with aphasia after stroke, and behavioral gains have been shown to coincide with white matter neuroplasticity. However, most brain-behavior studies have been carried out in the chronic phase after stroke, with limited generalizability to earlier phases. Furthermore, few studies have investigated neuroplasticity patterns during spontaneous recovery (i.e., not related to a specific treatment) in the first months after stroke, hindering the investigation of potential early compensatory mechanisms. Finally, the majority of previous research has focused on damaged left hemisphere pathways, while neglecting the potential protective value of their right hemisphere counterparts for language recovery. To address these outstanding issues, we present a longitudinal study of thirty-two patients with aphasia (21 males and 11 females, M = 69.47 years, SD = 10.60 years) who were followed up for a period of 1 year with test moments in the acute (1-2 weeks), subacute (3-6 months) and chronic phase (9-12 months) after stroke. Constrained Spherical Deconvolution-based tractography was performed in the acute and subacute phase to measure Fiber Bundle Capacity (FBC), a quantitative connectivity measure that is valid in crossing fiber regions, in the bilateral dorsal arcuate fasciculus (AF) and the bilateral ventral inferior fronto-occipital fasciculus (IFOF). First, concurrent analyses revealed positive associations between the left AF and phonology, and between the bilateral IFOF and semantics in the acute - but not subacute - phase, supporting the dual-stream language model. Second, neuroplasticity analyses revealed a decrease in connection density of the bilateral AF - but not the IFOF - from the acute to the subacute phase, possibly reflecting post stroke white matter degeneration in areas adjacent to the lesion. Third, predictive analyses revealed no contribution of acute FBC measures to the prediction of later language outcomes over and above the initial language scores, suggesting no added value ofthe diffusion measures for languageprediction. Our study provides new insights on (changes in) connectivity of damaged and undamaged language pathways in patients with aphasia in the first months after stroke, as well as if/how such measures are related to language outcomes at different stages of recovery. Individual results are discussed in the light of current frameworks of language processing and aphasia recovery.

The role of the hippocampus in statistical learning and language recovery in persons with post stroke aphasia.

Although several studies have aimed for accurate predictions of language recovery in post stroke aphasia, individual language outcomes remain hard to predict. Large-scale prediction models are built using data from patients mainly in the chronic phase after stroke, although it is clinically more relevant to consider data from the acute phase. Previous research has mainly focused on deficits, i.e., behavioral deficits or specific brain damage, rather than compensatory mechanisms, i.e., intact cognitive skills or undamaged brain regions. One such unexplored brain region that might support language (re)learning in aphasia is the hippocampus, a region that has commonly been associated with an individual's learning potential, including statistical learning. This refers to a set of mechanisms upon which we rely heavily in daily life to learn a range of regularities across cognitive domains. Against this background, thirty-three patients with aphasia (22 males and 11 females, M = 69.76 years, SD = 10.57 years) were followed for 1 year in the acute (1-2 weeks), subacute (3-6 months) and chronic phase (9-12 months) post stroke. We evaluated the unique predictive value of early structural hippocampal measures for short-term and long-term language outcomes (measured by the ANELT). In addition, we investigated whether statistical learning abilities were intact in patients with aphasia using three different tasks: an auditory-linguistic and visual task based on the computation of transitional probabilities and a visuomotor serial reaction time task. Finally, we examined the association of individuals' statistical learning potential with acute measures of hippocampal gray and white matter. Using Bayesian statistics, we found moderate evidence for the contribution of left hippocampal gray matter in the acute phase to the prediction of long-term language outcomes, over and above information on the lesion and the initial language deficit (measured by the ScreeLing). Non-linguistic statistical learning in patients with aphasia, measured in the subacute phase, was intact at the group level compared to 23 healthy older controls (8 males and 15 females, M = 74.09 years, SD = 6.76 years). Visuomotor statistical learning correlated with acute hippocampal gray and white matter. These findings reveal that particularly left hippocampal gray matter in the acute phase is a potential marker of language recovery after stroke, possibly through its statistical learning ability.

Arithmetic learning in children: An fMRI training study.

Arithmetic learning is characterized by a change from procedural strategies to fact retrieval. fMRI training studies in adults have revealed that this change coincides with decreased activation in the prefrontal cortex (PFC) and that within the parietal lobe, a shift occurs from the intraparietal sulcus (IPS) to the angular gyrus (AG). It remains to be determined whether similar changes can be observed in children, particularly because children often recruit the hippocampus (HC) during arithmetic fact retrieval, an observation that has not been consistently found in adults. In order to experimentally manipulate arithmetic strategy change, 26 typically developing 9- to-10-year-olds completed a six day at-home training of complex multiplication items (e.g. 16 × 4). Before and after training, children were presented with three multiplication conditions during fMRI: (1) complex to-be-trained/trained items, (2) complex untrained items and (3) single-digit items. Behavioral data indicated that training was successful. Similar to adults, children showed greater activity in the IPS and PFC for the untrained condition post-training, indicating that the fronto-parietal network during procedural arithmetic problem solving is already in place in children of this age. We did not observe the expected training-related changes in the HC. In contrast to what has been observed in adults, greater activity in the AG was not observed for the trained items. These results show that the brain processes that accompany the learning of arithmetic facts are different in children as compared to adults.

Fact retrieval or compacted counting in arithmetic-A neurophysiological investigation of two hypotheses.

There is broad consensus on the assumption that adults solve single-digit multiplication problems almost exclusively by fact retrieval from memory. In contrast, there has been a long-standing debate on the cognitive processes involved in solving single-digit addition problems. This debate has evolved around two theoretical accounts. Proponents of a fact-retrieval account postulate that these are also solved through fact retrieval, whereas proponents of a compacted-counting account propose that solving very small additions (with operands between 1 and 4) involves highly automatized and unconscious compacted counting. In the present electroencephalography (EEG) study, we put these two accounts to the test by comparing neurophysiological correlates of solving very small additions and multiplications. Forty adults worked on an arithmetic production task involving all (nontie) single-digit additions and multiplications. Afterward, participants completed trial-by-trial strategy self-reports. In our EEG analyses, we focused on induced activity (event-related synchronization/desynchronization, ERS/ERD) in three frequency bands (theta, lower alpha, upper alpha). Across all frequency bands, we found higher evidential strength for similar rather than different neurophysiological processes accompanying the solution of very small addition and multiplication problems. In the alpha bands, evidence for similarity was even stronger when operand-1-problems were excluded. In two additional analyses, we showed that ERS/ERD can differentiate between self-reported problem-solving strategies (retrieval vs. procedure) and between very small n × 1 and n + 1 problems, demonstrating its high sensitivity to cognitive processes in arithmetic. The present findings support a fact-retrieval account, suggesting that both very small additions and multiplications are solved through fact retrieval. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Oscillatory electroencephalographic patterns of arithmetic problem solving in fourth graders.

Numerous studies have identified neurophysiological correlates of performing arithmetic in adults. For example, oscillatory electroencephalographic (EEG) patterns associated with retrieval and procedural strategies are well established. Whereas fact retrieval has been linked to enhanced left-hemispheric theta ERS (event-related synchronization), procedural strategies are accompanied by increased bilateral alpha ERD (event-related desynchronization). It is currently not clear if these findings generalize to children. Our study is the first to investigate oscillatory EEG activity related to strategy use and arithmetic operations in children. We assessed ERD/ERS correlates of 31 children in fourth grade (aged between nine and ten years) during arithmetic problem solving. We presented multiplication and subtraction problems, which children solved with fact retrieval or a procedure. We analyzed these four problem categories (retrieved multiplications, retrieved subtractions, procedural multiplications, and procedural subtractions) in our study. In summary, we found similar strategy-related patterns to those reported in previous studies with adults. That is, retrieval problems elicited stronger left-hemispheric theta ERS and weaker alpha ERD as compared to procedural problems. Interestingly, we observed neurophysiological differences between multiplications and subtractions within retrieval problems. Although there were no response time or accuracy differences, retrieved multiplications were accompanied by larger theta ERS than retrieved subtractions. This finding could indicate that retrieval of multiplication and subtraction facts are distinct processes, and/or that multiplications are more frequently retrieved than subtractions in this age group.

Next Directions in Measurement of the Home Mathematics Environment: An International and Interdisciplinary Perspective.

This article synthesizes findings from an international virtual conference, funded by the National Science Foundation (NSF), focused on the home mathematics environment (HME). In light of inconsistencies and gaps in research investigating relations between the HME and children's outcomes, the purpose of the conference was to discuss actionable steps and considerations for future work. The conference was composed of international researchers with a wide range of expertise and backgrounds. Presentations and discussions during the conference centered broadly on the need to better operationalize and measure the HME as a construct - focusing on issues related to child, family, and community factors, country and cultural factors, and the cognitive and affective characteristics of caregivers and children. Results of the conference and a subsequent writing workshop include a synthesis of core questions and key considerations for the field of research on the HME. Findings highlight the need for the field at large to use multi-method measurement approaches to capture nuances in the HME, and to do so with increased international and interdisciplinary collaboration, open science practices, and communication among scholars.

The value of structural brain imaging in explaining individual differences in children's arithmetic fluency.

How do different measures of brain structure correlate with individual differences in arithmetic fluency? This paper builds on two previously published studies in which individual differences in children's arithmetic fluency were correlated with measures of white (Polspoel et al., 2019) and grey matter (Polspoel et al., 2020) in one sample of children. We combined the brain imaging data of these two studies with measures of cognitive abilities that have been shown to be predictive of arithmetic fluency, i.e., numerical magnitude processing, working memory and rapid automatized naming (RAN). This allowed us to investigate to which extend the observed structural brain imaging measures uniquely correlated with children's arithmetic fluency, on top of each other as well as on top of the abovementioned cognitive variables. Participants were 43 typically developing 9-10-year-olds. All measures were added to a hierarchical multiple regression model. This regression model showed that the white matter integrity of the right inferior longitudinal fasciculus and the cortical complexity of the left postcentral gyrus remained unique predictors of individual differences in arithmetic when the abovementioned cognitive variables were taken into account. This indicates that structural neuroimaging measures can explain individual differences in arithmetic performance that are not merely accounted for by relevant cognitive predictors.

Developmental brain dynamics of numerical and arithmetic abilities.

The development of numerical and arithmetic abilities constitutes a crucial cornerstone in our modern and educated societies. Difficulties to acquire these central skills can lead to severe consequences for an individual's well-being and nation's economy. In the present review, we describe our current broad understanding of the functional and structural brain organization that supports the development of numbers and arithmetic. The existing evidence points towards a complex interaction among multiple domain-specific (e.g., representation of quantities and number symbols) and domain-general (e.g., working memory, visual-spatial abilities) cognitive processes, as well as a dynamic integration of several brain regions into functional networks that support these processes. These networks are mainly, but not exclusively, located in regions of the frontal and parietal cortex, and the functional and structural dynamics of these networks differ as a function of age and performance level. Distinctive brain activation patterns have also been shown for children with dyscalculia, a specific learning disability in the domain of mathematics. Although our knowledge about the developmental brain dynamics of number and arithmetic has greatly improved over the past years, many questions about the interaction and the causal involvement of the abovementioned functional brain networks remain. This review provides a broad and critical overview of the known developmental processes and what is yet to be discovered.

Can the interference effect in multiplication fact retrieval be modulated by an arithmetic training? An fMRI study.

Single-digit multiplications are thought to be associated with different levels of interference because they show different degrees of feature overlap (i.e., digits) with previously learnt problems. Recent behavioral and neuroimaging studies provided evidence for this interference effect and showed that individual differences in arithmetic fact retrieval are related to differences in sensitivity to interference (STI). The present study investigated whether and to what extent competence-related differences in STI and its neurophysiological correlates can be modulated by a multiplication facts training. Participants were 23 adults with high and 23 adults with low arithmetic competencies who underwent a five-day multiplication facts training in which they intensively practiced sets of low- and high-interfering multiplication problems. In a functional magnetic resonance imaging (fMRI) test session after the training, participants worked on a multiplication verification task that comprised trained and untrained problems. Analyses of the behavioral data revealed an interference effect only in the low competence group, which could be reduced but not resolved by training. On the neural level, competence-related differences in the interference effect were observed in the left supramarginal gyrus (SMG), showing activation differences between low- and high-interfering problems only in the low competent group. These findings support the idea that individuals' low arithmetic skills are related to the development of insufficient memory representations because of STI. Further, our results indicate that a short training by drill (i.e., learning associations between operands and solutions) was not fully effective to resolve existing interference effects in arithmetic fact knowledge.

Associations Between Repeating Patterning, Growing Patterning, and Numerical Ability: A Longitudinal Panel Study in 4- to 6-Year Olds.

The present study aimed to analyze the direction of the associations between repeating patterning, growing patterning, and numerical ability. Participants were 410 children who were annually assessed on their repeating patterning, growing patterning, and numerical ability, at ages 4, 5, and 6 years (i.e., spring 2017, 2018, and 2019). A cross-lagged panel model identified bidirectional associations between all three abilities from ages 4 to 5 years while taking into account spatial skills. From ages 5 to 6 years, both patterning abilities predicted later numerical ability, but the reverse was no longer true. Associations between performances on both pattern types also disappeared. Results highlight the unique associations between repeating patterning, growing patterning, and numerical ability, above spatial skills.

No Association Between the Home Math Environment and Numerical and Patterning Skills in a Large and Diverse Sample of 5- to 6-year-olds.

Selecting a large and diverse sample of 5-6-year-old preschool children (179 boys and 174 girls; M age = 70.03 months, SD age = 3.43), we aimed to extend previous findings on variability in children's home math environment (i.e., home math activities, parental expectations, and attitudes) and its association with children's mathematical skills. We operationalized mathematics in a broader way than in previous studies, by considering not only children's numerical skills but also their patterning skills as integral components of early mathematical development. We investigated the effects of children's gender and socioeconomic status (SES) on their home math environment, examined the associations between children's home math environment and their mathematical skills, and verified whether these associations were moderated by children's gender and/or SES. Parents of 353 children completed a home math environment questionnaire and all children completed measures of their numerical (e.g., object counting) and patterning skills (e.g., extending repeating patterns). Results indicated no effect of children's gender on their home math environment. There was no effect of SES on the performed home math activities, but small SES differences existed in parents' math-related expectations and their attitudes. We found no evidence for associations between children's home math environment and their mathematical skills. Furthermore, there were no moderating effects of gender or SES on these associations. One explanation for these findings might relate to the characteristics of the general preschool system in the country of the present study (Belgium). Future studies should consider the effect of the preschool learning environment because it might explain differences between studies and countries with regard to the home math environment and its association with mathematical skills.

Cognitive correlates of dyslexia, dyscalculia and comorbid dyslexia/dyscalculia: Effects of numerical magnitude processing and phonological processing.

Specific learning disorders (i.e., dyscalculia and dyslexia) are common, as is their comorbidity. It has been suggested that the core cognitive deficit in dyscalculia is an impairment in numerical magnitude processing; similarly, in dyslexia, phonological processing deficits are considered to be the main cognitive deficit. Cognitive theories on comorbid dyslexia/dyscalculia have suggested a number of hypotheses about which cognitive deficits underlie the comorbidity. However, few studies have thus far directly compared the abovementioned cognitive correlates of dyscalculia and dyslexia. In this study, we assessed symbolic and non-symbolic numerical magnitude and three subcomponents of phonological processing (phonological awareness, lexical access and verbal short-term memory). In addition, we investigated children's domain-general spatial and verbal skills. The effect of these cognitive correlates on dyscalculia, dyslexia and their comorbidity was explored. We did not find differences between children with and without dyscalculia on numerical magnitude processing. On the other hand, children with dyscalculia had significantly lower spatial skills compared to children without dyscalculia. Children with dyslexia performed significantly lower on all subcomponents of phonological processing. Finally, we found an additive effect for comorbid dyslexia/dyscalculia: impairments in children with co-occurring dyslexia and dyscalculia were similar to the sum of the impairments in the isolated dyslexia and isolated dyscalculia groups. The strongest unique predictor of isolated dyscalculia and comorbid dyslexia/dyscalculia was spatial skills, the strongest unique predictor of isolated dyslexia was phonological awareness. As only a limited number of cognitive variables were assessed in this study and the sample sizes were very small, we should be cautious when interpreting these results.

Probing the Relationship Between Home Numeracy and Children's Mathematical Skills: A Systematic Review.

The concept of home numeracy has been defined as parent-child interactions with numerical content. This concept started to receive increasing attention since the last decade. Most of the studies indicated that the more parents and their children engage in numerical experiences, the better children perform in mathematical tasks. However, there are also contrasting results indicating that home numeracy does not play a role or that there is a negative association between the parent-child interactions and children's mathematics performance. To shed light on these discrepancies, a systematic review searching for available articles examining the relationship between home numeracy and mathematical skills was conducted. Thirty-seven articles were retained and a p-curve analysis showed a true positive association between home numeracy and children's mathematical skills. A more qualitative investigation of the articles revealed five common findings: (1) Advanced home numeracy interactions but not basic ones are associated with children's mathematical skills. (2) Most participants in the studies were mothers, however, when both parents participated and were compared, only mothers' reports of formal home numeracy activities (i.e., explicit numeracy teaching) were linked to children's mathematical skill. (3) Formal home numeracy activities have been investigated more commonly than informal home numeracy activities (i.e., implicit numeracy teaching). (4) The number of studies that have used questionnaires to assess home numeracy is larger compared with the ones that have used observations. (5) The majority of the studies measured children's mathematical skills with comprehensive tests that index mathematical ability with one composite score rather than with specific numerical tasks. These five common findings might explain the contradictory results regarding the relationship between home numeracy and mathematical skills. Therefore, more research is necessary to draw quantitative conclusions about these five points.

Towards Greater Collaboration in Educational Neuroscience: Perspectives From the 2018 Earli-SIG22 Conference.

The special issue resulting from the 2018 Earli-SIG22 conference reflects the current state of the field, the diversity of methods, the persevering limitations and promising directions towards solutions. About half of the empirical papers in this special issue that consist of three parts, uses behavioral, self-report or qualitative measures to understand the "mind" level of Mind, Brain, and Education. The other half investigates the "brain" level, using neuroimaging but also genetics or eye-tracking to gain access to the wider range of biological substrates of learning and cognition. These biological studies mostly have added value by refining psychological theories, such that these inspire new hypotheses to test in the field, to ultimately better inform teaching. Importantly, the special issue presents several approaches to more intensive, bi-directional and systematic practice-research collaborations to better connect the "mind" and "brain" levels to education, and to equip researchers to realize such collaborations successfully in the future.