1.
J Org Chem
; 66(16): 5438-43, 2001 Aug 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11485467
RESUMO
A highly stereoselective approach to (-)-2-epilentiginosine and (+)-lentiginosine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether. The two naturally occurring indolizidines are each obtained enantioselectively (> or = 99:1) in ca. 8.5% overall yield.
Assuntos
Alcaloides/síntese química , Antineoplásicos/síntese química , Indolizinas/síntese química , Alcaloides/química , Antineoplásicos/química , Glicosídeo Hidrolases/antagonistas & inibidores , Indolizinas/química
2.
J Org Chem
; 65(21): 6966-72, 2000 Oct 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11031017
RESUMO
A highly stereoselective approach to (-)-slaframine and its probable biosynthetic precursor (+)-(1S,8aS)-1-hydroxyindolizidine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether.
