1.
Bioorg Med Chem Lett
; 18(18): 4968-71, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18760922
RESUMO
We report here the parallel synthesis of 200 compounds based on squaric acid template. These compounds are obtained via a one-step solution-phase procedure starting from three squaric acid N-hydroxylamide esters precursors. The set of diverse reagents qualified (amines, anilines, amino-alcohols and amino-esters) makes this strategy suitable for the search of biologically active compounds. The library was screened on the zinc metalloenzyme ADAMTS-5 and hits with IC(50) in the range of 1-50 microM were identified.