RESUMO
Achiral chromophoric hosts, i.e. acyclic cucurbit[n]urils and molecular tweezers, were found to respond with characteristic Circular Dichroism (CD) spectra to the presence of micromolar concentrations of chiral hydrocarbons, terpenes, steroids, amino acids and their derivates, and drugs in water. In favourable cases, this allows for analyte identification or for reaction monitoring.
Assuntos
Hidrocarbonetos Aromáticos com Pontes/química , Imidazóis/química , Aminoácidos/química , Dicroísmo Circular , Peptídeos/química , Preparações Farmacêuticas/química , Esteroides/química , Terpenos/químicaRESUMO
Herein we report the synthesis and characterisation of the until recently unreported chiral C11 skeleton of tetracyclo[5.2.2.01,6.04,9]undecane ("trinorbornane") which could be obtained in 7% overall yield in 9 steps. This new rigid structural type was found to be present in the computer generated Chemical Universe Data-base (GDB) and has until now no real-world counterpart.