RESUMO
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare disorder associated with increased mortality and morbidity. There are currently two drugs approved for IPF but their safety and efficacy profile in real-world settings in Spain is not well understood. METHODS: An observational, multicentre, prospective study was carried out among patients with IPF who started treatment with pirfenidone or nintedanib from 2015 to 2021. Data regarding clinical characteristics, drug adherence, safety profiles and clinical outcomes between these two drugs were collected. RESULTS: 232 patients were included in the analysis. There were no meaningful differences between both groups at baseline. Patients who started pirfenidone showed a decreased risk for treatment withdrawal compared with those starting nintedanib (HR 0.65 (95% CI 0.46 to 0.94; p=0.002)). Time to first adverse event and all-cause mortality was similar between study groups. Risk factors for withdrawal were female sex, diarrhoea and photosensitivity. CONCLUSIONS: in this real-world study, both pirfenidone and nintedanib showed similar efficacy profiles. Pirfenidone was associated with less treatment discontinuations due to side effects.
Assuntos
Fibrose Pulmonar Idiopática , Indóis , Piridonas , Humanos , Fibrose Pulmonar Idiopática/tratamento farmacológico , Fibrose Pulmonar Idiopática/mortalidade , Feminino , Masculino , Espanha , Piridonas/uso terapêutico , Piridonas/efeitos adversos , Estudos Prospectivos , Idoso , Indóis/uso terapêutico , Indóis/efeitos adversos , Resultado do Tratamento , Pessoa de Meia-Idade , Antifibróticos/uso terapêutico , Adesão à Medicação/estatística & dados numéricos , Idoso de 80 Anos ou maisRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Sarcoma Alveolar de Partes Moles/patologia , Neoplasias Pulmonares/patologia , Sarcoma Alveolar de Partes Moles/diagnóstico por imagem , Hemoptise/complicações , Dispneia , Redução de Peso , Tomografia Computadorizada por Raios X , Broncoscopia , Tomografia por Emissão de Pósitrons , BiópsiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/tratamento farmacológico , Fibrose Pulmonar/diagnóstico , Fumantes , Hipotireoidismo/complicações , Biópsia por Agulha/métodos , Granuloma de Células Plasmáticas Pulmonar/complicações , Biomarcadores Tumorais , Carcinoma de Células Escamosas/patologia , Corticosteroides/uso terapêuticoRESUMO
No disponible