Comparison of the helical tomotherapy against the multileaf collimator-based intensity-modulated radiotherapy and 3D conformal radiation modalities in lung cancer radiotherapy.

OBJECTIVES: The aim of this study was to compare three-dimensional (3D) conformal radiotherapy and the two different forms of IMRT in lung cancer radiotherapy. METHODS: Cases of four lung cancer patients were investigated by developing a 3D conformal treatment plan, a linac MLC-based step-and-shoot IMRT plan and an HT plan for each case. With the use of the complication-free tumour control probability (P(+)) index and the uniform dose concept as the common prescription point of the plans, the different treatment plans were compared based on radiobiological measures. RESULTS: The applied plan evaluation method shows the MLC-based IMRT and the HT treatment plans are almost equivalent over the clinically useful dose prescription range; however, the 3D conformal plan inferior. At the optimal dose levels, the 3D conformal treatment plans give an average P(+) of 48.1% for a effective uniform dose to the internal target volume (ITV) of 62.4 Gy, whereas the corresponding MLC-based IMRT treatment plans are more effective by an average ΔP(+) of 27.0% for a Δ effective uniform dose of 16.3 Gy. Similarly, the HT treatment plans are more effective than the 3D-conformal plans by an average ΔP(+) of 23.8% for a Δ effective uniform dose of 11.6 Gy. CONCLUSION: A radiobiological treatment plan evaluation can provide a closer association of the delivered treatment with the clinical outcome by taking into account the dose-response relations of the irradiated tumours and normal tissues. The use of P - effective uniform dose diagrams can complement the traditional tools of evaluation to compare and effectively evaluate different treatment plans.

Radiation doses to patients undergoing barium meal and barium enema examinations.

The radiation doses received by patients during 41 barium meal (BM) and 42 barium enema (BE) examinations in two Greek hospitals are presented. Radiation dose was measured in terms of the dose area product (DAP). The effective dose and doses to certain organs were estimated using the ODS-60 software. Mean total DAP values were found to be 25 +/- 11 Gy cm2 for BM and 60 +/- 35 Gy cm2 for BE examinations, whereas the estimated mean values of effective dose were 8.6 +/- 4.0 and 24 +/- 16 mSv respectively. DAP to effective dose conversion coefficients were estimated to be 0.34 mSv per Gy cm2 for BM and 0.41 mSv per Gy cm2 for BE.

Radiation doses to patients undergoing coronary angiography and percutaneous transluminal coronary angioplasty.

A detailed study of radiation doses received by 168 patients who underwent coronary angiography (CAG) and 102 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) in two Greek hospitals is presented. Radiation dose was measured in terms of dose-area product (DAP). The contribution of fluoroscopy and cineradiography to the total DAP was examined separately for each radiological projection used in both procedures. Effective dose and doses to various organs were estimated with the help of the ODS-60 software. Total DAP was found to correlate linearly to fluoroscopy time and cine film length. Mean DAP values were found to be 80.8 +/- 28.0 Gy cm2 for CAG and 86.2 +/- 65.6 Gy cm2 for PTCAs, whereas the estimated mean values of effective dose were 20.9 +/- 7.5 and 23.2 +/- 18.1 mSv respectively. DAP to effective dose conversion coefficients were estimated to be 0.26 mSv/Gy cm2 for CAG and 0.27 mSv/Gy cm2 for PTCAs.