Treatment of Hypertension with Combination of Lisinopril/Hydrochlorothiazide.

INTRODUCTION: Paper is written on the basis of data collected in collaboration with family doctors in several cities in Bosnia and Herzegovina. MATERIAL AND METHODS: In this retrospective, randomized study was carried out processing of data collected by special design questionnaire from the field through studies and analyzes carried out in 5 health care institutions in the territory of Bosnia and Herzegovina. The study included 270 patients who underwent three consecutive medical examinations. RESULTS: Total reduction in blood pressure in average was 32.8 mmHg for systolic and 17.1 mmHg for diastolic, which is consistent with previously published results. Lisinopril/Hydrochlorothiazide is therefore a valuable therapy in the field of internal medicine. Study of this medication confirmed its efficacy in the treatment of hypertension. CONCLUSION: Control of high blood pressure in our patients according to data was very low, so it is necessary to intensify measures of prevention and treatment.

CLINICAL-EPIDEMIOLOGICAL STUDY ON STROKE PRESENCE IN THE POPULATION OF HERZEGOVINA-NERETVA CANTON INFLUENCED BY INVESTIGATED RISK FACTORS.

INTRODUCTION: Stroke is a rapid loss of brain function due to disturbance blood flow to the brain. The existence of multiple risk factors, the length of their duration, and severity of each factor individually, is positively correlated with the occurrence of stroke. Stroke is the third cause of disability and premature death for men and women. AIM: The aim of this research is that through clinical and epidemiological studies the origin and development of stroke to inspect the same level of representation in the population of the Herzegovina-Neretva Canton. MATERIAL AND METHODS: This survey covers the entire population of residents in the Herzegovina-Neretva Canton, and the number of patients who had a need for primary and secondary treating the symptoms of stroke. The very setting of this model of anthropological research modern human groups and theoretical estimates of the impact of genetic and / or environmental risk factors in the formation of phenotypic expression of complex traits of stroke, at the population level, resulted in the realization of the very methodology of this research. The study was conducted at the Department of Neurology, Regional Medical Center (RMC) "Dr. Safet Mujic" and the Department of Neurology, Clinical Center Mostar. These two health institutions, in addition to primary care are at the disposal for entire population of the Herzegovina-Neretva Canton and beyond. Data were collected by examining the details of the history of the board of hospitalized patients in the period from 1 January 2010-to 31 December 2014. The processed are 10 risk factors-potential causes of stroke. We also as research material, used records of hospital morbidity-the disease-illness statistics form (form number: 03-21-61; 03/02/60; 03/02/61; 09/03/60). RESULTS: In our study, stroke is the second most frequent in the period of investigation, and noted the rapid growth that is in 2010 and 10.21% to 14.52% in 2014. There was a slight statistically significant differences in relation to the number of infected men and women, and the same is in favor of the patients are female. The number of patients with ischemic stroke, 954 of them or 48.38% was male and 1,018 or 51.62% were female. Of the 10 possible risk factors, factor 6 has a statistically significant canonical factor value, of which hypertension-CVI and the level of P = 0009 *, p = secondary hypertension, 0034 *, hypertensive heart disease, p =, * 0021, Diabetes mellitus of P = 0029 *, p = Anemia, 0052 * and C-reactive protein (CRP) of p = 0049 *, respectively, these canonical factors carry the entire amount of information about the relations impact of certain risk factors in the onset and development of the brain shock. CONCLUSION: We conclude that there is a statistically significant correlation between the studied risk factors in the genesis of the origin and development of different types of stroke.

IMPACT OF FLUORIDE ON DENTAL HEALTH QUALITY.

INTRODUCTION: Fluoride is natural element that strengthens teeth and prevents their decay. Experts believe that the best way to prevent cavities is the use of fluoride from multiple sources. Studies even show that in some cases, fluoride can stop already started damage of the teeth. In children younger than 6 years fluoride is incorporated into the enamel of permanent teeth, making the teeth more resistant to the action of bacterial and acids in food. GOAL: The aim of this study is to determine the effects of improving the health status of teeth after six months treatment with the use of topical fluoridation 0.5% NaF, and the level and quality of the impact of treatment with chemical 0.5% NaF on the dental health of children at age from 8 to 15 years, in relation to gender and chronological age. This study included school children aged 8 to 15 years who visited health and dental services dependent in Mostar. RESULTS: It is obvious that after the implementation of treatment with 5% NaF by the method of topical fluoridation, health status of subjects from the experimental group significantly improved, so that at the final review 89.71% or 61 subjects of the experimental group had healthy (cured teeth), tooth with dental caries only 5.88% or 4 respondents tooth with dental caries and filling 4.41% or 3 respondents, extracted baby tooth 14.71% or 10 respondents, while for 13.24% of respondents was identified state with still unerupted teeth. Our findings are indirectly confirmed that the six-month treatment of fluoridation with 5% NaF, contributed to statistically significant improvement in overall oral health of the experimental group compared to the control group which was not treated by any dental treatment. CONCLUSION: It can be concluded that there is a statistically significant difference in the evaluated parameters of oral health of children in the control group compared to the studied parameters of oral health the experimental group of children at the final dental examination.

Valsartan in the treatment of hypertension.

INTRODUCTION: Hypertension represents an important public health problem. Effective treatment of hypertension is imperative for primary care. GOAL: The goal of this study was to examine the efficacy of Valsartan in the treatment of hypertension with emphasis on the overall efficacy in reduction of systolic and diastolic blood pressure in a sample of 738 patients. MATERIAL AND METHODS: The study lasted for 12 months (from January 1, 2012 until December 31, 2012 year) and conducted in 18 public health institutions in B&H. Parallel follow up of Valsartan antihypertensive effect through repeated measurements every three months was conducted. RESULTS AND DISCUSSION: Our results indicate that both systolic and diastolic blood pressure decreased significantly after 12 weeks of Valsartan treatment. Analysis of adverse effects did not showed statistical significance of side effects for total sample. Statistical analysis by Yates chi-square did not show the presence of statistically significant differences in adverse effects by gender. CONCLUSION: We conclude that Val or Val plus are effective and safe antihypertensive drugs for the treatment of mild to moderate

Interferon treatment of multiple sclerosis.

INTRODUCTION: IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) DIFFER: treatment of relapse, treatment slow the progression of the disease (immunomodulators and immunosuppression), and symptomatic treatment. THE AIM: The aim of this study is to analyze the application of interferon therapy in the treatment of MS-E: Process the disease, patients with multiple sclerosis who have passed the commission for multiple sclerosis at the Neurology Clinic of Clinical Center of Sarajevo University as a reference center for referral to the Commission for multiple sclerosis from the Federal Ministry of Health in 2009 year in terms of total number examined, gender differences, diagnostic tests (MRI, CSF, EP), neurological findings and EDSS scores. Provide a section through the continuous support and education of patients during the introduction Betaferon in therapy with the goal of education for self-use and reduce the incidence of side effects of interferon therapy. MATERIALS AND METHODS: The material for the work they were histories of patients who are registered as patients who have undergone a commission for MS at Department of Neurology, University Clinical Center in Sarajevo. The evaluation was retrospective. It was used a specially designed form, which is usually applied to patients referred to this committee. After the collected material was carried out data processing. The study comprised 34 patients who have undergone a commission of which 16 patients received interferon therapy. RESULTS: In 2009 at the Neurology Clinic CCUS have treated 34 patients who passed the committee for recommendation to interferon therapy (25 women and 9 men). The diagnosis of multiple sclerosis is safe based on the criteria of international panel in 2000. EDSS Average score for men was 1.8, 1.9 for women, the total EDSS score was 1.8. The gender ratio is 3:1 in women than in men. Sixteen patients received interferon by the Commission for multiple sclerosis, the Federal Ministry of Health and their therapy was initiated at the clinic. CONCLUSION: For the period of 2009, a total of 34 patients were examined with multiple sclerosis who received interferon treatment recommendations at the expense of the Federal Solidarity Fund at the Neurology Clinic CCUS Sarajevo. The average EDSS score was 1.8. There were no significant differences in neurological findings between patients who were previously treated with interferon and patients who were waiting for treatment.