Psychological burden in inpatient relatives: the forgotten side of medical management.

BACKGROUND: The burden of the hospital experience is a broad issue that has been evaluated in a particular context of intensive care unit (ICU). It is likely, however, that the load is heavy on families even in other hospital wards and not just in the ICU. The present study was designed to assess the prevalence of anxiety and depression in family members of patients admitted in a general medicine department, and to identify associated factors with those symptoms. METHODS: Patients' and relatives' socio-demographic data and information pertaining to the patients' health characteristics were collected. Family members completed the Arabic version of Hospital Anxiety and Depression Scale (HADS). Associations between anxiety or depression and covariates of interest were investigated using generalized estimating equations, for univariate and multivariate logistic regression analysis. RESULTS: The prevalence of anxiety (55.6%) and depression (41.1%) in family members remains high. The multivariate model identified three groups of factors associated with these symptoms: (i) Patient related: a short length of hospital stay is associated with depression (OR 1.04, 95% CI 1.01-1.08; P = 0.02); (ii) Family related: rural residence is associated with depression (OR 2.56, 95% CI 1.01-6.74; P = 0.04), and female gender is associated with anxiety and depression (OR 2.60, 95% CI 1.41-4.81; P = 0.002), (OR 3.04, 95% CI 1.62-5.70; P = 0.01), respectively; and (iii) Caregiver related: short length of visit (OR 1.08, 95% CI 1.03-1.13; P = 0.002) is associated with anxiety, admission to a share room (OR 2.56, 95% CI 1.25-5.23; P = 0.01) is associated with depression and a need for more information is associated with anxiety and depression (OR 1.78, 95% CI 1.02-3.10; P = 0.04),(OR 1.77, 95% CI 1.01-3.11; P = 0.04), respectively. CONCLUSION: The prevalence of symptoms of anxiety and depression in family members remains high at the end of acute health care. It is hoped that improving the provision of information will decrease the risk of psychological distress.

Prognostic factors of acute aluminum phosphide poisoning.

BACKGROUND: In Morocco, acute aluminum phosphide poisoning (AAlPP) is a serious health care problem. It results in high mortality rate despite the progress of critical care. AIMS: The present paper aims at determining the characteristics of AAlPP and evaluating its severity factors. SETTING AND DESIGN: We studied consecutive patients of AAlPP admitted to the medical intensive care unit (ICU) (Ibn Sina Hospital, Rabat, Morocco) between January 1992 and December 2007. MATERIALS AND METHODS: Around 50 parameters were collected, and a comparison was made between survivor and nonsurvivor groups. STATISTICAL ANALYSIS: Data were analyzed using Fisher exact test, Mann-Whitney U test and Cox regression model. RESULTS: Forty-nine patients were enrolled: 31 females and 18 males; their average age was 26+/-11 years. The ingested dose of aluminum phosphide was 1.2+/-0.7 g. Self-poisoning was observed in 47 cases, and the median of delay before admission to the hospital was 5.3 hours (range, 2.9-10 hours). Glasgow coma scale was 14+/-2. Shock was reported in 42.6% of the patients. pH was 7.1+/-0.4, and bicarbonate concentration was 16.3+/-8.8 mmol/L. Electrocardiogram abnormalities were noted in 28 (57%) cases. The mortality rate was 49% (24 cases). The prognostic factors were APACHE II (P=0.01), low Glasgow coma scale (P=0.022), shock (P=0.0003), electrocardiogram abnormalities (P=0.015), acute renal failure (P=0.026), low prothrombin rate (P=0.020), hyperleukocytosis (P=0.004), use of vasoactive drugs (P<0.001), use of mechanical ventilation (P=0.003). Multivariate analysis by logistic regression revealed that mortality in AAlPP correlated with shock (RR=3.82; 95% CI=1.12-13.38; P=0.036) and altered consciousness (RR=3.26; 95% CI=1.18-8.99; P=0.022). CONCLUSION: AAlPP is responsible for a high mortality, which is primarily due to hemodynamic failure.

[Effects of corticosteroids on adults with tuberculous meningitis admitted to intensive care unit: a propensity score analysis]. / Effets de la corticothérapie chez les adultes admis en réanimation pour méningite tuberculeuse: analyse par le score de propension.

INTRODUCTION: The beneficial effect of corticosteroids has been well established, particularly in patients free of infection with the human immunodeficiency virus. In intensive care units, the high risks of infection to which patients are exposed specifically could offset the neurological benefit of corticosteroids. The purpose of the study was to assess the effects of corticosteroids in adult patients with tuberculous meningitis admitted to intensive care unit. METHODS: Retrospective cohort study including all adult patients admitted to intensive care unit for tuberculous meningitis between January 1993 and December 2005. A propensity score case matching was performed using a multivariable logistic regression model, and matched pairs were examined for baseline characteristics and outcome by using conditional regression model. A multivariate Cox's proportional hazard model was used to assess the effects of corticosteroids in all patients adjusting for propensity score. The primary outcome was mortality at 60 days and the secondary outcome was the density of incidence of nosocomial infections. RESULTS: Two hundred and seventy patients were included. The mean age was 38+/-17 years, and the Glasgow coma scale was 12+/-3. The overall mortality was 43.3%. Ninety-four patients who had received corticosteroids were matched to 94 patients untreated with corticosteroids by the propensity score. The baseline characteristics were similar in the two groups except for hydrocephalus, which was more frequent in the group corticosteroids. The mortality rate was 47.9% in group Corticosteroids and 52.1% in group No corticosteroids (P=0.77). The case fatality rate in stage III patients, according to the British Medical Research Council criteria, was 61.5% in the group Corticosteroids versus 74.1% in the group No corticosteroids (P=0.33). Nosocomial infections were observed in 19.1 by 1000 days patient in group Corticosteroids versus 16.1 by 1000 days patient in group No corticosteroids (P=0.4). The outcome in all patients after adjusting for propensity score showed the same results. CONCLUSION: This study found no significant improvement in survival in adult patients with tuberculous meningitis admitted to intensive care who received dexamethasone. However, the confidence interval was in accordance with the 0.78 relative risk estimated by the meta-analysis Cochrane version 2008. There was no significant difference for nosocomial infections between the group Corticosteroids and the group No corticosteroids. A probable lack of statistical power may explain these results.