1.
ACS Med Chem Lett
; 6(6): 650-4, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26101568
RESUMO
Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain.