1.
Endocr Pathol
; 32(4): 517-523, 2021 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34019237
RESUMO
Gastric type 1 neuroendocrine tumours are considered to have low rates of proliferation and a good prognosis. We report here a patient with an aggressive well-differentiated high-grade gastric neuroendocrine tumour (gastric grade 3 NET), in a context of autoimmune gastritis. Consistent with grade 3 disease, the tumour had a Ki-67 proliferation index of 30%. Targeted next-generation sequencing identified variants of four genes, including a pathogenic ATM variant underlying the differentiation and metastatic potential of the tumour. Liver metastasis was diagnosed during follow-up, and the patient died after 6 years, due to disease progression.
Assuntos
Proteínas Mutadas de Ataxia Telangiectasia/genética , Tumores Neuroendócrinos/patologia , Neoplasias Gástricas/patologia , Idoso , Diferenciação Celular , Diagnóstico Diferencial , Evolução Fatal , Feminino , França , Humanos , Neoplasias Hepáticas/secundário , Gradação de Tumores , Invasividade Neoplásica , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/genética , Tumores Neuroendócrinos/metabolismo , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/genética , Neoplasias Gástricas/metabolismo
2.
Anaesth Crit Care Pain Med
; 36(2): 131-132, 2017 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27671980