Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
2.
Am J Trop Med Hyg ; 93(1): 18-23, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26013373

RESUMO

To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.


Assuntos
Anticorpos Antivirais/imunologia , Antígenos Virais/sangue , Vírus da Dengue/imunologia , Dengue/epidemiologia , Doenças Endêmicas , Febre/epidemiologia , Adolescente , Brasil/epidemiologia , Criança , Estudos de Coortes , Colômbia/epidemiologia , Dengue/sangue , Dengue/imunologia , Monitoramento Epidemiológico , Feminino , Febre/imunologia , Febre/virologia , Humanos , Incidência , Masculino , México/epidemiologia , Estudos Prospectivos , Porto Rico/epidemiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA