[Processes of absorption and utilization of glucose in newborn infants with intrauterine hypotrophy]. / Protsessy vsasyvaniia i utilizatsii gliukozy u novorozhdennykh s vnutriutrobnoi gipotrofiei.

Overall 75 neonates with intrauterine hypotrophy (IH) and 19 healthy children were examined for glucose absorption and utilization according to the glucose tolerance test data. IH neonates were revealed to have and increase of glucose absorption and retardation of its utilization. The high blood glucose concentrations seen 2 hours after the test support functional insufficiency of the pancreas in IH.

[Study of the formation of intestinal microflora in newborn infants staying with or separated from their mothers]. / Izuchenie formirovaniia mikroflory kishechnika u novorozhdennykh detei pri sovmestnom i razdel'nom prebyvanii s mater'iu.

In children of the first month of life, the formation of normal intestinal microflora was studied depending on whether they stayed with mothers or alone in the maternity home. Thirty healthy neonates born to young healthy mothers with a history of a favourable course of pregnancy which progressed to the delivery via the natural maternal passages were examined. Intestinal microbiocenosis in the newborn turned out more physiological provided they were placed at the "mother-child" department as compared to that when the newborn stayed alone. Organization of the joint staying of mothers and children in the wards of the maternity home increases the colonization resistance of the newborn, favours normal adaptation and may be one of the factors bringing about the diminution of the rate of pyoseptic diseases in the newborn.

[Effect of chronic intrauterine hypoxia on purine compound metabolism in the erythrocytes of newborn infants in the early neonatal period]. / Vliianie khronicheskoi vnutriutrobnoi gipoksii na obmen purinovykh soedinenii v éritrotsitakh krovi novorozhdennykh v rannem neonatal'nom periode.

The content of purine compounds in red blood cells was measured and compared in 21 neonates with a history of chronic intrauterine hypoxia, depending on the condition at birth and the early period of adaptation. The content of purine compounds in whole blood was measured at the moment of birth and on days 1, 3 and 5 of life. It has been disclosed that the pattern of purine metabolism abnormality in funic red blood cells makes it possible to predict the course of the early period of adaptation. Changes in the content of hypoxanthine and inosine monophosphate appeared to be most remarkable.

[Contents of bioelements in blood of newborn infants with a history of chronic intrauterine hypoxia]. / Soderzhanie bioélementov v krovi novorozhdennykh, perenesshikh khronicheskuiu vnutriutrobnuiu gipoksiiu.

Emission analysis with the use of induced plasma was employed to measure the content of 9 bioelements (potassium, sodium, calcium, magnesium, phosphorus, iron, copper, zinc and selenium) in the blood serum of 82 neonates with a history of chronic intrauterine hypoxia and in 19 normal children at birth and in the course of early adaptation. It has been shown that the content of bioelements in the blood of normal neonates was marked by a number of characteristic features reflecting to a considerable degree the processes of metabolic adaptation of the children to the intrauterine life. The neonates with a history of hypoxia demonstrated the unbalance of bioelements most pronounced by day 3 of life. The treatment instituted did not make the content of bioelements in the neonates' blood return to normal.

[Indicators of lipid peroxidation and the level of essential microelements in healthy newborn infants and in those with a history of intrauterine hypotrophy]. / Pokazateli perekisnogo okisleniia lipidov i soderzhanie nezamenimykh mikroelementov u zdorovykh novorozhdennykh i pri vnutriutrobnoi gipotrofii.

The authors describe the results of studying lipid peroxidation, total antioxidant activity of plasma and the content of essential trace elements (iron, copper, zinc and selenium) in 35 healthy neonates and in 32 with intrauterine hypotrophy, grades I-III, at birth and the course of the early neonatal period. It has been found that in the neonates with a history of intrauterine hypotrophy, activation of lipid peroxidation resulted in the decrease of plasma antioxidant activity and in the changes of the concentration of essential trace elements.

[Nonspecific resistance of the body and predisposition to acute leukemia in children]. / Nespetsificheskaia ustoichivost' organizma i predraspolozhennost' k zabolevaniiu ostrym leikozom u detei.

An analysis of 422 Moscow hospital records of children suffering from acute leukemia during the period from 1959 and continuing through to 1979 showed that the proportion of those with morphologically "average" weight and body length values at birth, was significantly lower in the group with leukemia, than in the control group of healthy children. Genetic structure of leukemic and healthy children was found to be significantly different by phenotypic combinations of 2 loci (ABO and Rhesus). The distribution of children for their age at the beginning of the disease was studied. The results revealed that children with the low weight and body length values at birth, as well as those having ARh+ and BRh+ blood groups, develop leukemia earlier than those with "average" characteristics and blood groups other than ARh+ and BRh+. The anamnesis of children which developed leukemia demonstrated a higher infectious-inflammatory disease frequency, as compared with the control group. By comparison of some parental characteristics of two groups of children, it was found that parents of children which became ill, were on the average older at the moment of baby's birth than parents of healthy children. Babies of 2nd, 3rd and subsequent deliveries were registered more frequently in the group with leukemia than in that of healthy children. Evidence presented confirms the efficiency of the population-genetic approach to the problem of nonspecific resistance of human organism to diseases.