RESUMO
A new quinoline alkaloid named helietidine ( 1), and seven known compounds ( 2 - 8) have been isolated from the stem barks of Helietta longifoliata. The structures of the new and the known compounds were established on the basis of spectral evidence, especially by 2D NMR ( 1H- 1H COSY, NOESY, HMQC, HMBC). In addition, the volatile constituents of H. longifoliata leaves were analysed by gas chromatography-mass spectrometry (GC-MS). Twenty-five constituents were identified representing ca. of 96 % of the oil, and limonene (17.50 %), germacrene D (16.60 %), elemol (11.81 %), bicyclogermacrene (11.67 %), guaiol (11.53), and epi-alpha-bisabolol (7.24 %) were the most abundant components. The oil was bioactive against some Gram-positive and Gram-negative bacteria, as revealed by bioautography.
Assuntos
Alcaloides/isolamento & purificação , Antibacterianos/isolamento & purificação , Cumarínicos/isolamento & purificação , Quinolinas/isolamento & purificação , Rutaceae/química , Alcaloides/química , Alcaloides/farmacologia , Antibacterianos/química , Antibacterianos/farmacologia , Cumarínicos/química , Cumarínicos/farmacologia , Testes de Sensibilidade Microbiana , Quinolinas/química , Quinolinas/farmacologia , Staphylococcus/efeitos dos fármacosRESUMO
Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds. Their structures were determined on the basis of spectroscopic data (IR, (1)H- and (13)C-NMR, MS). In addition, the antispasmodic activity of the crude extract of Z. hyemale and three other more abundant isolated compounds (4, 5 and 10) were studied in two different antispasmodic test models on isolated rat ileum and only the crude ethanolic extract presented antispasmodic activity.
Assuntos
Alcaloides/farmacologia , Amidas/farmacologia , Benzamidas/farmacologia , Extratos Vegetais/farmacologia , Quinolinas/farmacologia , Rutaceae , Acetilcolina/administração & dosagem , Alcaloides/química , Alcaloides/isolamento & purificação , Amidas/química , Amidas/isolamento & purificação , Animais , Compostos de Bário/administração & dosagem , Benzamidas/química , Benzamidas/isolamento & purificação , Benzofenantridinas , Cloretos/administração & dosagem , Relação Dose-Resposta a Droga , Íleo/efeitos dos fármacos , Íleo/fisiologia , Técnicas In Vitro , Espectroscopia de Ressonância Magnética , Masculino , Estrutura Molecular , Contração Muscular/efeitos dos fármacos , Parassimpatolíticos/farmacologia , Fenantridinas/isolamento & purificação , Casca de Planta/química , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Quinolinas/química , Quinolinas/isolamento & purificação , Ratos , Ratos Wistar , Espectroscopia de Luz Próxima ao InfravermelhoRESUMO
From Humirianthera ampla, Icacinaceae, were isolated a phthalate, lupeol, â-sitosterol, glycosyl- sitosterol, one known annonalide diterpene and two new diterpenes named Humirianthol and Acrenol. Humirianthol and Acrenol were determined by 1D and 2D NMR spectroscopic techniques to be 3 â, 20:14 â, 16-diepoxy-3 á, 15 á-dihydroxy-7-pimaren-19, 6 â-olide and 3 â, 20-epoxi-3 á, 15, 16-trihydroxy-7-pimaren-19, 6 â-olide, respectively. Acrenol has antimicrobial activity.
