Higher sirt1 is associated with a better body composition in master sprinters and untrained peers.

Sirt1 is an enzyme involved in several anti-aging pathways. Associations between Sirt1, age, and body fat (BF) were assessed in master sprinters (MS; n = 35; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n = 32; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n = 24; 47.29 ±8.04 yr.). BF was assessed using a skinfold protocol, and Sirt1 was measured in plasma by using commercial kits. Sirt1 of MS (17.18 ±4.77 ng/mL) was higher than UMA (6.36 ±2.29 ng/mL; p<0.0001) and did not differ from UY (20.26 ±6.20 ng/mL). Relative BF of MS was lower than UMA (12.71 ±4.07% vs. 22.13 ±4.18%; p<0.0001). Sirt1 was negatively correlated with chronological age (r = -0.735; p<0.0001) when combining UY and UMA in the analysis. However, when Sirt1 of MS and UY was analyzed together, no significant relationship between Sirt1 and chronological age was observed (r = -0.243; p = 0.083). Sirt1 correlated inversely with BF (r = -0.743; p<0.0001) for UY and UMA. Stepwise multiple regression revealed that being either a young or master athlete and body adiposity are possible predictors of Sirt1 levels. MS and UY were associated with higher levels of Sirt1, while UMA and increased BF were associated with lower levels of this enzyme. The relationships among Sirt1, BF, and chronological age of young and middle-aged non-athletes were not statistically significant when the middle-aged participants were MS. These findings suggest possible links between Sirt1 and body composition, which may play roles in the rate of biological aging.HighlightsLower levels of Sirt1 are associated with higher body fat.Master athlete lifestyle seems to promote higher Sirt1 Levels.

Metabolic and hormonal responses to chronic blood-flow restricted resistance training in chronic kidney disease: a randomized trial.

Maintenance of glycemic and lipemic homeostasis can limit the progression of diabetic kidney disease. Resistance training (RT) is effective in controlling glycemia and lipemia in kidney disease; however, the effect of RT with blood flow restriction (RT+BFR) on these metabolic factors has not been investigated. We aimed to verify if chronic (6 months) RT and RT+BFR performed by patients with stage-2 chronic kidney disease (CKD) improves their glycemic homeostasis and immunometabolic profiles. Patients with CKD under conservative treatment (n = 105 (33 females)) from both sexes were randomized into control (n = 35 (11 females); age 57.6 ± 5.2 years), RT (n = 35 (12 females); age 58.0 ± 6.2 years), and RT+BFR (n = 35 (10 females); 58.0 ± 6.4 years) groups. Chronic RT or RT+BFR (6 months) was performed 3 times per week on non-consecutive days with training loading adjusted every 2 months, RT 50%-60%-70% of 1RM, and RT+BFR 30%-40%+50% of 1RM and fixed repetition number. Renal function was estimated with the glomerular filtration rate and serum albumin level. Metabolic, hormonal, and inflammatory assessments were analyzed from blood samples. Six months of RT and RT+BFR were similarly effective in improving glucose homeostasis and hormone mediators of glucose uptake (e.g., irisin, adiponectin, and sirtuin-1), decreasing pro-inflammatory and fibrotic proteins, and attenuating the progression of estimated glomerular filtration rate. Thus, RT+BFR can be considered an additional exercise modality to be included in the treatment of patients with stage 2 chronic kidney disease. Trial registration number: U1111-1237-8231. URL: http://www.ensaiosclinicos.gov.br/rg/RBR-3gpg5w/, no. RBR-3gpg5w. Novelty: Glycemic regulation induced by resistance training prevents the progression of CKD. Chronic RT and RT+BFR promote similar changes in glycemic regulation. RT and RT+BFR can be considered as non-pharmacological tools for the treatment of CKD.

Resistence exercise improves anxiety and depression in middle-age women / Exercício resistido melhora a ansiedade e depressão de mulheres de meia-idade

ABSTRACT This study aimed to compare levels of anxiety and depression of middle-aged women trained in resistance exercise and sedentary. Forty women, 20 exercised (GT) and 20 non-exercised (CG) (GT = 56.9 ± 6.6 years, 27.3 ± 4.8 kg/m2), (CG = 51.5 ± 5.0 years, 27.0 ± 7.7 kg/m2) underwent the study. The participants answered the HAD scale with 14 questions related to levels of anxiety and depression. The CG had higher scores of depression and anxiety than GT. The results for anxiety (GT = 5.2 ± 2.7, CG = 9.5 ± 4.0) and depression (GT = 4.1 ± 2.6, CG = 7.7 ± 4.0) differed significantly (P<0.05) between groups. Middle-Aged women who participated in a resistance exercise program presented a better mental health as evidenced by a lower levels of depression and anxiety in relation to sedentary counterpartners.

RESUMO O estudo comparou níveis de ansiedade e depressão de mulheres treinadas em exercício resistido e de sedentárias. Quarenta mulheres, 20 treinadas (GT) e 20 não treinadas (GC), (GT=56,9±6,6 anos; 27,3±4,8kg/m2), (GC=51,5±5,0 anos; 27,0±7,7 kg/m2) participaram do estudo. As participantes responderam a escala HAD com 14 questões relacionadas aos níveis de ansiedade e depressão. O GC apresentou escores mais elevados de depressão e ansiedade que o GT. Os resultados para ansiedade (GT=5,2±2,7; GC=9,5±4,0) e depressão (GT=4,1±2,6; GC=7,7±4,0) diferiram significativamente (P<0,05) entre os grupos. Pode-se concluir que mulheres de meia idade que participaram de programa de exercícios resistidos apresentaram melhor estado de saúde mental verificados por menores níveis de depressão e ansiedade do que mulheres sedentárias.