ORAI1 defect in a patient with disseminated CMV infection and severe hypotonia.

BACKGROUND: A clinical presentation similar to severe combined immunodeficiency (SCID) with defective T cell activation but normal lymphocyte development occurs due to certain molecule defects including ORAI1- and STIM1. CASE: A four-month-old girl sufferd from fever, restlessness, diarrhea, and poor weight gain following the neonatal period. There was consanguinity and a positive family history. She had hypotonia and spontaneous opisthotonic posture. Refractory and extensive CMV infections were detected; immunological investigations revealed normal quantitative immunoglobulins and low numbers of CD3+, CD4+, and CD8+ cells. The next generation sequencing analysis revealed a mutation in the ORAI1 gene. CONCLUSIONS: The present patient`s history of refractory and widespread CMV infections shows a clinically substantial reduction in resistance against opportunistic microorganisms. This case emphasizes the importance of considering STIM1 and ORAI1 defects in patients with SCID phenotype and neurologic involvement, such as hypotonia.

Effects of thyme on halitosis in gingivitis patients: Can thyme mouthwash prevent halitosis-A randomized trial.

OBJECTIVES: Bad breath is a condition that negatively affects people's social interactions and quality of life. The aim of this study was to evaluate the effect of thyme mouthwash on intraoral halitosis, gingival index (GI) and plaque index (PI) in patients with gingivitis. METHODS: In this retrospective study, 60 gingivitis patients (30 women/30 men) received initial periodontal treatment followed by oral hygiene instructions (OHI) and then were divided into four groups: The control group (C) received only OHI, while chlorhexidine (CHX) mouthwash was prescribed to the CHX group, Zinc acetate and CHX diacetate mouthwash was prescribed to the zinc acetate and CHX diacetate (ZnA) group, and the thyme (T) group was instructed to use thyme mouthwash. GI, PI and volatile sulfur compound (VSC) values were recorded at baseline and at the first week of treatment. RESULTS: The initial values of the recorded parameters did not differ significantly between the groups. In all groups, VSCs, GI and PI decreased after treatment (p = 0.001). There was no significant difference between the PI values of the groups after treatment (p = 0.188). On the contrary, the GI and VSC values after treatment were significantly different between the groups (p = 0.001). GI values were highest in the control group and lowest in the CHX group. In terms of VSCs, a significant difference was found between groups T and C, and between groups T and ZnA (p = 0.001). CONCLUSION: This study showed that the use of thyme mouthwash after periodontal treatment was effective in improving bad breath and gingivitis in gingivitis patients.

Topography of the Anatomical Landmarks of Carotid Bifurcation and Clinical Significance.

OBJECTIVE: Carotid bifurcation (CB) and its terminal branches are the most common sites of atherosclerotic plaques. In surgical treatment, these plaques can be reached by an endarterectomy technique. The success of the technique can be achieved with good anatomical knowledge of these arteries and their relationships with surrounding structures. MATERIALS AND METHODS: The study was performed retrospectively on archived images of patients with computed tomography angiography (CTA). Two hundred forty-seven patients who met the criteria were included in this study. Three-dimensional (3D) reconstructions of two-dimensional CTA images were made automatically using the open-source software Horos v.4.0.0. The distance between the transverse plane passing through the bifurcation point (BP) and the defined planes of the surrounding structures was evaluated. RESULTS: CB was observed below the mastoid process, gonion point, and hyoid bone. CB was observed above the thyroid cartilage. Carotid bifurcation was seen at 15 levels in total, the lowest in the upper 1/3 of the C6 vertebral body and the highest in the lower 1/3 of the C2 vertebral body. In all cases, the most common level was the C3 lower level. CONCLUSION: All these values, which emerged as a result of the study, provide general information about the topography of the CB according to the neighboring structures. Estimating the location of the CB according to the gonion and hyoid bone will give a more accurate result. The vertebral level on the right side increased in direct proportion to age; there was no similar relationship on the left side. It is necessary to be aware of these anatomical variations in order to prevent various iatrogenic complications.