1.
Anal Chem
; 95(6): 3121-3146, 2023 02 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36716428
2.
Int J Mol Sci
; 19(10)2018 Oct 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30322072
RESUMO
The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development.