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1.
AIDS Res Hum Retroviruses ; 9(9): 869-74, 1993 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7903044

RESUMO

We have investigated HTLV-I and HTLV-II infection in children born to HTLV-I-seropositive or indeterminate Western blot mothers in Martinique by using the polymerase chain reaction (PCR). Only HTLV-I and no HTLV-II-positive samples were found in this study. All the samples from HTLV-I-seropositive children and adults were PCR positive, whereas the four HIV-I-seropositive and Western blot HTLV-I-negative mothers and their eight children were all PCR negative. Therefore, PCR and serology were in complete agreement in these patients. However, two of the six mothers who were first indeterminate by Western blot, and who later became seronegative, were found positive by PCR. Of the 27 children (ages 2-12 years), born to HTLV-I-seropositive and PCR-positive mothers, 2 were seropositive and PCR positive, 5 were seronegative and PCR positive with 2 primer pairs in gag and pol, and 4 were seronegative and PCR positive with only 1 of the primer pairs. In contrast to an initial rate of transmission of 7% estimated by serology we found a rate of transmission of 28 to 41% (whether or not children who were positive with only one of the primer pairs were included). Thus, our study confirms that PCR is useful in detecting HTLV-I infection in children before seroconversion and underlines the potential lack of sensitivity of serology to detect contaminating HTLV-I blood units in endemic areas.


Assuntos
Infecções por HTLV-I/transmissão , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Complicações Infecciosas na Gravidez/microbiologia , Provírus/isolamento & purificação , Sequência de Bases , Western Blotting , Pré-Escolar , DNA Viral/sangue , Anticorpos Antideltaretrovirus/sangue , Feminino , Infecções por HTLV-I/congênito , Infecções por HTLV-I/embriologia , Infecções por HTLV-I/epidemiologia , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/microbiologia , Vírus Linfotrópico T Tipo 1 Humano/genética , Vírus Linfotrópico T Tipo 1 Humano/imunologia , Vírus Linfotrópico T Tipo 2 Humano/genética , Humanos , Martinica/epidemiologia , Dados de Sequência Molecular , Sondas de Oligonucleotídeos , Reação em Cadeia da Polimerase , Gravidez , Provírus/genética , Viremia/microbiologia
2.
Presse Med ; 17(25): 1293-6, 1988 Jun 25.
Artigo em Francês | MEDLINE | ID: mdl-2969578

RESUMO

In view of the ethnic and geographical peculiarities of the French department of Martinique and of the endemic character of hepatitis in tropical countries, we studied the prevalence of infections with hepatitis A, B and delta viruses in that region. A group of 10,109 blood donors and a group of about 100 patients were selected on account of their liver symptoms. As regards hepatitis A, the study of the 2 groups was completed by a sero-epidemiological survey of 509 children and teenagers aged from 1 to 18 years. The prevalence of the HB antigen among blood donors was 1.3 per cent, i.e. about 10 times higher than in Europe and 7 times lower than in hyperendemic tropical areas. It was 2.5 times higher in the male than in the female population; 84 per cent of HBs-positive donors had anti-HBe antibodies, 9 per cent had HBe antigen and 7 per cent had neither one nor the other. This distribution is coherent with a population of symptomless carriers. The prevalence of anti-HBs-positive sera was 34 per cent as against 70-95 per cent in highly endemic countries and 4-20 per cent in Europe; 1.9 per cent of the HBs donors studied and 8.8 per cent of the patients had anti-delta antibodies; 11 of the 13 anti-delta-positive subjects had anti-HBe antibodies and 2 had neither HBe nor anti-HBe. Between the ages of 1 and 3 years very few anti-HAV-positive subjects were observed. From 3 to 10 years, the percentage of seroconversions increased moderately. Between 10 and 20 years, the number of positive cases increased considerably reaching 67 per cent at 20 years and 100 per cent at and above 45 years. Among the patients, 97 were positive for IgG (96 per cent) and only 5 for IgM (4 per cent).


Assuntos
Hepatite A/epidemiologia , Hepatite B/epidemiologia , Hepatite D/epidemiologia , Adolescente , Adulto , Fatores Etários , Doadores de Sangue , Criança , Pré-Escolar , Feminino , Hepatite A/imunologia , Hepatite B/imunologia , Hepatite D/imunologia , Humanos , Lactente , Masculino , Martinica , Pessoa de Meia-Idade
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