RESUMO
BACKGROUND AND STUDY AIMS: Endoscopic ultrasound-guided biliary drainage (EUS-BD) can be performed entirely transgastrically (hepatogastrostomy/EUS-HG) or transduodenally (choledochoduodenostomy/EUS-CDS). It is unknown how both techniques compare. The aims of this study were to compare efficacy and safety of both techniques and identify predictors of adverse events. PATIENTS AND METHODS: Consecutive jaundiced patients with distal malignant biliary obstruction who underwent EUS-BD at multiple international centers were included. Technical/clinical success, adverse events, stent complications, and survival were assessed. RESULTS: A total of 121 patients underwent EUS-BD (CDS 60, HG 61). Technical success was achieved in 112 (92.56â%) patients (EUS-CDS 93.3 %, EUS-HG 91.8â%, Pâ=â0.75). Clinical success was attained in 85.5â% of patients who underwent EUS-CDS group as compared to 82.1â% of patients who underwent EUS-HG (Pâ=â0.64). Adverse events occurred more commonly in the EUS-HG group (19.67â% vs. 13.3â%, Pâ=â0.37). Both plastic stenting (OR 4.95, 95â%CI 1.41â-â17.38, Pâ=â0.01) and use of non-coaxial electrocautery (OR 3.95, 95â%CI 1.16â-â13.40, Pâ=â0.03) were independently associated with adverse events. Length of hospital stay was significantly shorter in the CDS group (5.6 days vs. 12.7 days, Pâ<â0.001). Mean follow-up duration was 151â±â159 days. The 1-year stent patency probability was greater in the EUS-CDS group [0.98 (95â%CI 0.76â-â0.96) vs 0.60 (95â%CI 0.35â-â0.78)] but overall patency was not significantly different. There was no difference in median survival times between the groups (Pâ=â0.36) CONCLUSIONS: Both EUS-CDS and EUS-HG are effective and safe techniques for the treatment of distal biliary obstruction after failed ERCP. However, CDS is associated with shorter hospital stay, improved stent patency, and fewer procedure- and stent-related complications. Metallic stents should be placed whenever feasible and non-coaxial electrocautery should be avoided when possible as plastic stenting and non-coaxial electrocautery were independently associated with occurrence of adverse events.