Feasibility and safety of left atrial appendage closure in a patient with previous foramen ovale occlusion: a case report.

BACKGROUND: Left atrial appendage (LAA) closure is an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation (AF) at high bleeding risk. Patients with a previous percutaneous closure of a patent foramen ovale (PFO) present an increased risk for developing AF during their life, and the presence of an atrial septal device renders future percutaneous left atrial access more challenging. Very few cases of LAA occlusion in patients with a preexisting PFO closure device have been previously reported. CASE SUMMARY: A 74-years old woman was admitted to our hospital for symptomatic severe anaemia during direct oral anticoagulant treatment. Her past medical history reported an ischaemic stroke at the age of 55, at that time a PFO was diagnosed and a STARFlex™ PFO occluder (NMT Medical, Boston, MA, USA) was implanted. During the current hospitalization, the patient underwent a colonoscopy that showed colonic angiodysplasias unsuitable for endoscopic treatment and LAA closure was indicated for stroke prevention. After a multimodality pre-procedural planning that included a transoesophageal echocardiogram, a cardiac computed tomography scan and a three-dimensional cardiac model printing, the procedure was planned and the LAA successfully occluded. DISCUSSION: LAA closure can be performed safely and effectively in patients carrying a previously implanted PFO occlusion device. In complex settings, a pre-procedural multimodality imaging is critical for improving the procedural safety and success rate. We describe the first case of percutaneous LAA closure in a patient with a prior PFO occlusion with the implantation of a STARflex™ septal occlusion device.

[An unusual case of postinfarction ventricular septal rupture in a patient with angiographically normal coronary arteries]. / Un caso inusuale di rottura di setto interventricolare postinfartuale in coronarie indenni da lesioni.

Ventricular septal defect is a rare but potentially fatal complication of acute myocardial infarction. It usually occurs during the first episode of myocardial infarction, most often in patients with single vessel coronary artery disease and total occlusion of the culprit vessel, in the absence of an adequate collateral circulation. However, this complication is observed in patients with myocardial infarction with normal coronary arteries and its pathogenesis may be attributed to different mechanisms such as inflammation, hypercoagulable state or coronary vasospasm. We report the case of a 59-year-old female patient with anteroseptal myocardial infarction developed 4 days after admission, complicated by ventricular septal defect with signs of congestive heart failure and angiographically normal coronary arteries.

Glycosylated hemoglobin and coronary artery disease in patients without diabetes mellitus.

BACKGROUND: Abnormal glucose metabolism is a major determinant of coronary artery disease (CAD) and mortality in developed countries. Glycosylated hemoglobin (HbA1c) is a more stable, accurate parameter of glucose homeostasis than fasting glycemia, thus providing prognostic information in diabetics. However, its role and relationship with CAD remains unclear in non-diabetics. PURPOSE: To evaluate the relationship between HbA1c and CAD in a consecutive cohort of patients without diabetes mellitus. METHODS: Non-diabetic patients undergoing coronary angiography between April 2007 and October 2012 were included. Additionally carotid intima-media thickness (C-IMT) was evaluated during hospitalization in a consecutive cohort of patients. RESULTS: 1,703 consecutive patients were included and divided according to HbA1c tertiles (<5.5%, 5.5%-5.79%, ≥5.8%). HbA1c was associated with aging (p<0.001); hypercholesterolemia (p=0.01); renal failure (p=0.006); hypertension (p=0.002); previous myocardial infarction (p=0.004); previous percutaneous coronary intervention (p=0.01); indication to angiography (p=0.01); use of angiotensin receptor blockers (p=0.01); beta-blockers (p=0.03); nitrates (p=0.02); statins (p=0.008); calcium antagonists (p=0.01); diuretics (p<0.001); acetylsalicylic acid (p<0.001); baseline glycemia (p<0.001); triglycerides (p=0.02); and uric acid (p=0.04). HbA1c, but not fasting glycemia, was significantly associated with the prevalence of CAD (adjusted OR=1.51, 95% CI=1.15, 1.97, p=0.002), with 5.8% identified by the receiver operating characteristic (ROC) curve as the best cut-off value for CAD prediction. HbA1c was significantly associated with C-IMT and carotid plaques prevalence. CONCLUSIONS: Among non-diabetic patients, higher HbA1c even within the normal range is significantly associated with the risk of CAD. Future large studies are needed to evaluate whether more aggressive cardiovascular prevention can reduce the risk of CAD among patients with HbA1c ≥ 5.8%.