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1.
Pediatr Blood Cancer ; 52(4): 491-6, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19058214

RESUMO

BACKGROUND: Demographics, outcome, and management of idiopathic thrombocytopenic purpura (ITP) in children present differences between countries. Although several factors influence outcome, it is impossible to predict at diagnosis which patients will have acute or chronic disease. High rates of spontaneous remission in chronic ITP have been reported. PROCEDURE: Data concerning 1,683 patients with ITP diagnosed from 1981 to date are presented; outcome was evaluated in 1,418 children. RESULTS: Remarkable presenting features were an incidence peak in the first 2 years of age and male predominance in patients <24 months of age. Three age groups with different recovery rates (P < 0.001) were established (2-12 months: 89.8%; 1-8 years: 71.3%; 9-18 years: 49.0%). Platelet count <10 x 10(9)/L and history of previous illness were associated with higher remission rates only in patients >12 months of age. The score developed by the NOPHO Group showed a predictive value of 83.9% for acute ITP. Spontaneous remission between 6 months and 11 years from diagnosis was achieved by 107 of 325 (32.9%) non-splenectomized children with chronic ITP, and in 44.9% of them between 6 and 12 months from diagnosis. CONCLUSIONS: Age and score were main prognostic factors. Infants <1 year of age are a special group with a brief course and very high recovery rate that are not influenced by other prognostic factors. Definition of groups based on age and scoring could be useful to establish differential management guidelines. The cut-off value to define chronic ITP should be changed to 12 months.


Assuntos
Púrpura Trombocitopênica Idiopática/epidemiologia , Púrpura Trombocitopênica Idiopática/fisiopatologia , Adolescente , Distribuição por Idade , Argentina/epidemiologia , Criança , Pré-Escolar , Demografia , Feminino , Humanos , Incidência , Lactente , Masculino , Prognóstico , Distribuição por Sexo
2.
Pediatr Blood Cancer ; 47(5 Suppl): 737-9, 2006 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-16933257

RESUMO

Two hundred thirty of 696 evaluable children were identified as having chronic idiopathic thrombocytopenic purpura (ITP). Splenectomy was performed in 30 (13%), achieving remission in 22 (73%). Favorable response was associated to higher initial platelet count. Spontaneous remission was achieved by 53/200 non-splenectomized patients (26.5%), up to 10 years from diagnosis. More than half of them recovered between 6th and 12th month from diagnosis. The recovery rate was significantly higher (P=0.03) in children aged<9 years (31.2%) than in older children (14.6%). No reliable factor predictive of response in individual cases is still available.


Assuntos
Avaliação de Resultados em Cuidados de Saúde , Púrpura Trombocitopênica Idiopática/cirurgia , Esplenectomia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Doença Crônica , Bases de Dados Factuais , Seguimentos , Humanos , Lactente , Contagem de Plaquetas , Púrpura Trombocitopênica Idiopática/diagnóstico , Indução de Remissão , Remissão Espontânea , Resultado do Tratamento
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