RESUMO
During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1:1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (µmol/l) of total AA (3,176 ± 722), essential AA (889 ± 221), and branched chain AA (459 ± 140) levels in HFR were similar to those in AFB (3,399 ± 621, 938 ± 277, and 463 ± 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood.
Assuntos
Aminoácidos/sangue , Hemodiafiltração , Diálise Renal , Idoso , Estudos Transversais , Soluções para Hemodiálise/administração & dosagem , Humanos , Pessoa de Meia-IdadeRESUMO
Studies in patients with uremia due to diabetes mellitus treated with CAPD show that the kinetics of amino acid equilibration between dialysate and plasma behave differently from those in patients with uremia of different etiology. Diabetics also have larger amino acid losses in dialysate.
Assuntos
Aminoácidos/metabolismo , Diabetes Mellitus/metabolismo , Diálise Peritoneal Ambulatorial Contínua , Diálise Peritoneal , Uremia/metabolismo , Adulto , Complicações do Diabetes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Uremia/terapiaRESUMO
The equilibrium between plasma and peritoneal dialysis fluid has been studies for 23 amino acids during peritoneal exchanges at dwell times up to 8 hours in patients on CAPD. It is demonstrated that equilibration is a particular process typical for each amino acid which after 8 hour is nearly complete only for Glycine, Alanine and Asparagine.
Assuntos
Assistência Ambulatorial , Aminoácidos/metabolismo , Diálise Peritoneal , Adulto , Feminino , Humanos , Cinética , Masculino , Pessoa de Meia-Idade , Diálise Peritoneal/métodos , Equilíbrio PosturalRESUMO
Amino acid losses in peritoneal dialyzate during CAPD were less than 2 g a day (15, 128 micrometers). CAPD does not correct the tyrosine/phenylalanine ratio in plasma and does not prevent accumulation of 3-methylhistidine.
