Residual malaria transmission: Magnitude and drivers of persistent Plasmodium infections despite high coverage of control interventions in Burkina Faso, West Africa.

This study collected baseline data on malaria vectors to characterize the drivers and the factors of persistent malaria transmission in two villages in the western part of Burkina Faso. Mosquitoes were collected in each village using the Human landing catch and pyrethrum spray catch and identified using the morphological keys. Molecular analyses were performed for the identification of An. gambiae complex species, the detection of Plasmodium infection and kdr-995F mutation. Anopheles mosquito larvae were also collected in the same villages, reared to adult's stage for the WHO tube and cone tests performing. The physical integrity of the LLINs already used by people in each village was assessed using the proportional hole index (pHI). An. gambiae s.l. was the main malaria vector accounting for 79.82% (5560/6965) of all collected mosquitoes. The biting pattern of An. gambiae s.l. was almost constant during the survey with an early aggressiveness before 8 p.m. and later biting activity after 6 a.m. The EIR varied from 0.13 to 2.55 infected bites per human per night (average: 1.03 infected bites per human per night). An. gambiae s.l. populations were full susceptible to Chlorpyrifos-methyl (0.4%) and Malathion (5%) with high kdr-995F mutation frequencies (>0.8). The physical integrity assessment showed high proportion of good nets in Santidougou compared to those collected in Kimidougou. This study highlighted a persistence of malaria transmission despite the intense use of vector control tools as LLINs and IRS by correlating mosquito biting time and human behavior. It provided a baseline guide for the monitoring of the residual malaria transmission in sub-Saharan Africa and encouraging the development of new alternative strategies to support the current malaria control tools.

Epidemiology of Dengue in patients with febrile syndrome at Saint Camille Hospital, Ouagadougou, Burkina Faso from 2020 to 2

: Dengue is still a public health problem in tropical countries. This disease, which had almost disappeared in some areas of the world, has become re-emergent in certain parts of the world including Africa.The aim of this study is to determine the seroprevalence and evolution of Dengue virus (DENV) infection from 2020 to 2021 at the Hospital Saint Camille de Ouagadougou (HOSCO), Burkina Faso. Methodology: This was a descriptive analytical study of patients seen in general practice with febrile syndrome referred for serological diagnosis of Dengue at the HOSCO laboratory over a period of 2 years (January 1, 2020 ­ December 31, 2021). The "Dengue Duo (AgNS1/IgM/IgG)" kit from SD Bioline was used for the rapid diagnosis through the detection of NS1 antigen and IgM/IgG antibodies in plasma. Data were analysed with SPSS version 20.0 software. Association between demographic data and prevalence of DENV infection was determined by Chisquare test and odds ratio (with 95% confidence interval). P value less than 0.05 was considered statistical significance. Results: A total of 2957 patients aged 0-94 years were referred for serological diagnosis of DENV infection at the HOSCO laboratory over the period 2020-2021, comprising 56.3% females and 43.7% males. The overall prevalence of acute DENV infection (NS1Ag positive) was 5.4% (159/2957), with 2.4% (41/1700) in 2020 and 9.4% (118/1257) in 2021 (OR=4.192, 95% CI=2.915-6.028, p<0.0001). The prevalence of acute DENV infection of 7.0% (91/1292) in the males was significantly higher than 4.1% (68/1665) in the females (OR=1.779, 95% CI=1.288-2.458, p=0.0005), and also significantly higher in age groups 20-29 years (7.6%), 10-19 years (6.9%) and 40-49 years (5.8%) than other age groups (X 2=14.928, p=0.0107). The overall prevalence of DENV IgM and IgG antibodies was 3.2% and 37.3% respectively. The prevalence of DENV IgG antibodies was significantly higher in males (44.0%) than females (32.1%) (OR=1.667, 95%CI=1.434-1.938, p<0.0001) and in age groups 30-39 (43.4%), 40-49 (44.0%) and >50 years (49.3%) than other age groups (X2=121.0, p<0.0001), indicating that past exposure to DENV infection is higher among males and older age groups. The peak of DENV infection was between October and November with 84.3% (134/159) of NS1Ag positivity occurring during this period. Conclusion: The present study reports a high prevalence of acute Dengue virus infection in patients from October to November. To eradicate Dengue which has become a tropical silent epidemic, interventions such as vector control, availability of and accessibility to diagnostic tests, and good therapeutic management are of great importance

[Management of patients with Covid 19: analysis of prescription drugs at Gabriel Touré University Hospital]. / Prise en charge des patients atteints de Covid 19 : analyse des prescriptions médicamenteuses au CHU Gabriel Touré.

COVID-19 was declared a pandemic in March 2020. For case management, Mali has created several treatment sites including the site of the CHU Gabriel Touré. AIMS: The objective of the study was to analyse drug prescriptions for the COVID-19 treatment at the CHU Gabriel Touré. METHODS: We performed a retrospective and descriptive study from April to September 2020. Drug prescriptions and hospital records were used to collect data. Prescriptions and hospital records were used to collect data. RESULTS: A total of 29 patients were hospitalized. The median age was 44 years, 75.90% of patients had at least one pathology associated with COVID-19. The number of prescriptions was 333 comprising 870 lines of prescriptions including 33.21% for standard treatments, and 66.79% for associated pathologies. with 86.23% available at the Hospital Pharmacy. Chloroquine, dosed at 250mg, was administered at 500mg twice a day. The national guidelines from the treatment of COVID-19 recommends 200mg of chloroquine in two doses. Vitamin C was prescribed for all patients although not included in the national guidelines. The class of drugs for the blood and blood-forming organs was the most prescribed (31.49%). The average cost of treatments was 65,602 ± 106,858 FCFA with a maximum of 567,860 FCFA. An evaluation of prescriptions in other treatment sites is necessary.

La COVID-19 est une infection virale qui s'est propagé dans tout le monde. Pour la prise en charge des cas, le Mali a créé des sites de traitement dont celui du CHU Gabriel Touré. OBJECTIF: C'était d'analyser les prescriptions médicamenteuses pour le traitement de la COVID-19 au CHU Gabriel Touré. MÉTHODOLOGIE: L'étude était rétrospective et descriptive et a concerné la période d'avril à septembre 2020. Elle s'est déroulée au Centre de Traitement COVID-19 du CHU Gabriel Touré et à la Pharmacie Hospitalière de cet hôpital. Les ordonnances et les registres d'hospitalisation ont servi à collecter les données. RÉSULTATS: Au total, 29 patients ont été hospitalisés. L'âge médian était de 44ans, 75,90% des patients présentaient au moins une pathologie associée à la COVID-19. Le nombre d'ordonnances était de 333 comportant 870 lignes de prescriptions dont 33,21% de traitements standards et 66,79% pour les pathologies associées avec 86,23% disponibles à la Pharmacie Hospitalière. Le phosphate de chloroquine, dosé à 250mg, était administré à 500mg deux fois quotidiennement. Dans les directives nationales le phosphate de chloroquine était à 100mg pour 200mg trois fois quotidienne. La vitamine C non prévue dans les directives a été prescrite à tous les patients. La classe des médicaments du sang et des organes hématopoïétiques a été les plus prescrits (31,49%). Le coût moyen des traitements était de 65602±106858 FCFA avec maximum de 567860 FCFA. Une évaluation des prescriptions dans les autres sites de traitement est nécessaire.

[Epidemioclinical and Therapeutic Study of Condylomas (Genital Warts) in Dermato-Venereology Department (CHU Treichville, Abidjan, Côte d'Ivoire, 2013-2016)]. / Étude épidémioclinique et thérapeutique des condylomes vénériens dans un service de dermatovénéréologie (CHU Treichville, Abidjan, Côte d'Ivoire, 2013-2016).

We have conducted a retrospective study in the dermatology department of the CHU Treichville in Abidjan during 4 years. Three hundred and fifty cases of venereal warts were recorded with a hospital frequency of 1.5%, an average age of 29.37, a female predominance (51.3%), and a sex ratio (M/F) of 0.94. We have observed a giant condyloma in 0.9%, a main localization to the vulva (47.7%) and male genitalia (34.6%); HIV testing carried out in 60.8% of patients was positive in 80.7% of cases, all HIV1. Electrocoagulation was the mean treatment (93.1%), followed by cryotherapy (15 cases), chemotherapy (6 cases), and surgery (3 cases). Recurrences were reported in 9 cases (2.6%) of which more than half has occurred within a month.

Nous avons réalisé une étude rétrospective au sein du service de dermatologie du CHU de Treichville d'Abidjan pendant quatre ans. Trois cent cinquante cas de condylomes vénériens ont été recensés (1,5 % des hospitalisations en dermatologie) ; une moyenne d'âge de 29,37 ans ; une prédominance féminine (51,3 %) et un sexe-ratio (H/F) de 0,94. Nous avons observé un condylome géant dans 0,9 %, une localisation à la vulve (47,7 %) et aux organes génitaux externes masculins (34,6 %). Le dépistage du VIH-1, réalisé dans 60,8 % des cas, s'est avéré positif dans 80,7 % des cas, toujours avec VIH-1. L'électrocoagulation a été le traitement de choix (93,1 %), suivie de la cryothérapie (15 cas), la chimiothérapie (6 cas) et la chirurgie (3 cas). Des récidives ont été relevées dans neuf cas (2,6 %), dont plus de la moitié avant un mois.

Efficacité du Dakin Cooper Stabilisé® dans la prise en charge des plaies drépanocytaires

Objectif : Apprécier l'efficacité et la tolérance du Dakin Cooper Stabilisé® dans le traitement des plaies drépanocytaires.Patients et méthodes : Il s'agit d'une étude prospective descriptive sur 35 patients, ayant des plaies drépanocytaires, recrutés au centre de Dermatologie de Treichville (Abidjan, Côte d'Ivoire) de janvier 2010 à déceRésultat : La douleur a disparu chez 91,4% des patients, une semaine après le début du traitement. La guérison est survenue chez 80% des patients après six semaines.Conclusion : Le Dakin Cooper Stabilisé® est efficace en six semaines dans le traitement des plaies drépanocytaires et est bien toléré

[Squamous cell carcinoma secondary to Buruli ulcer in West Africa]. / Carcinomes épidermoïdes sur cicatrices d'ulcère de Buruli en Afrique de l'Ouest.

BACKGROUND: Buruli ulcer is an infection caused by Mycobacterium ulcerans occurring in tropical areas. In West Africa, it is an emerging threat mainly affecting children aged under 15years. This chronic disease is complicated by dystrophic scars in which squamous cell carcinoma can occur in the long term. PATIENTS AND METHODS: This is a retrospective study of squamous cell carcinomas in Buruli ulcer scars seen at the Treichville University Hospital (Abidjan, Ivory Coast) over a five-year period. RESULTS: During the study period, 8cases were observed and concerned young adults presenting Buruli ulcer in their childhood. Tumours were restricted to the limbs, with loco-regional invasion. Treatment was primarily surgical. Four of the patients died. DISCUSSION: The risk of recurrence of cancer in these scars remains poorly evaluated, highlighting the importance of long-term monitoring strategies for human patients in order to ensure rapid identification of any changes in Buruli ulcer scars.

Target-site resistance mutations (kdr and RDL), but not metabolic resistance, negatively impact male mating competiveness in the malaria vector Anopheles gambiae.

The implementation of successful insecticide resistance management strategies for malaria control is currently hampered by poor understanding of the fitness cost of resistance on mosquito populations, including their mating competiveness. To fill this knowledge gap, coupled and uncoupled Anopheles gambiae s.l. males (all M form (Anopheles coluzzii)) were collected from mating swarms in Burkina Faso. This multiple insecticide resistant population exhibited high 1014F kdr(R) allele frequencies (>60%) and RDL(R) (>80%) in contrast to the Ace-1(R) allele (<6%). Kdr heterozygote males were more likely to mate than homozygote resistant (OR=2.36; P<0.001), suggesting a negative impact of kdr on An. coluzzii mating ability. Interestingly, heterozygote males were also more competitive than homozygote susceptible (OR=3.26; P=0.006), suggesting a heterozygote advantage effect. Similarly, heterozygote RDL(R)/RDL(S) were also more likely to mate than homozygote-resistant males (OR=2.58; P=0.007). Furthermore, an additive mating disadvantage was detected in male homozygotes for both kdr/RDL-resistant alleles. In contrast, no fitness difference was observed for the Ace-1 mutation. Comparative microarray-based genome-wide transcription analysis revealed that metabolic resistance did not significantly alter the mating competitiveness of male An. coluzzii mosquitoes. Indeed, no significant difference of expression levels was observed for the main metabolic resistance genes, suggesting that metabolic resistance has a limited impact on male mating competiveness. In addition, specific gene classes/GO terms associated with mating process were detected including sensory perception and peroxidase activity. The detrimental impact of insecticide resistance on mating competiveness observed here suggests that resistance management strategies such as insecticide rotation could help reverse the resistance, if implemented early.

IRM du cancer du col de l'uterus en milieu tropical

Introduction : Le cancer du col de l'uterus est le premier cancer de la femme en Cote d'Ivoire avec un fort de mortalite eleve .Son diagnostic tardif et l'absence de radiotherapie limite sa prise en charge. L'IRM permet le bilan d'extension.Objectif : Decrire les aspects epidemiologiques et radiologiques du cancer du col de l'uterus en milieu tropical.Materiels et Methode : Etude descriptive retrospective realisee sur 12 mois. Ont ete inclus 50 patientes presentant un cancer histologiquement prouve.Resultats : La moyenne d'age des patientes etait de 48;42 ans. Les lesions etaient dans 50% des cas endocervicales; dans 33% des cas infiltrantes. Le diametre tumoral moyen etait de 6;29cm; superieur au seuil d'operabilite de 04 cm. Il a ete observe 80% d'invasion vaginale; 73% d'invasion parametriale; 40% d'infiltration de la vessie ou du rectum. 41% des tumeurs presentaient une extension lymphatique. Les tumeurs etaient au stade IB de FIGO dans 6% des cas; IIB dans 33% des cas; et IVA dans 60% des cas.Conclusion : Le cancer du col de l'uterus est de decouverte tardive dans les pays tropicaux. L'IRM permet au mieux la stadification de la tumeur

La radiofrequence percutanee dans la prise en charge de l'hepatocarcinome : un espoir pour nos pays en voie de developpement

Objectif : Evaluer l'apport de la radiofrequence percutanee dans la prise en charge de l'hepatocarcinome en terme de faisabilite et d'efficacite sous nos tropiques. Materiel et Methodes :Etude retrospective sur une periode de 12 mois ayant porte sur l'analyse de tous les dossiers adresses dans notre service d'imagerie pour la prise en charge par radiofrequence percutanee d'hepatocarcinome apres discussion multidisciplinaire entre chirurgiens oncologues et radiologues digestifs. Cinq dossiers ont ete retenus. La necrose tumorale etait consideree comme complete en l'absence de prise de contraste arterielle nodulaire du site de radiofrequence sur l'examen TDM ou IRM de controle realise un a deux mois apres la procedure. Resultats :L'age moyen des patients etait de 64;4 ans. L'hepatopathie sous jacente etait de type cirrhotique pour tous les patients. Six nodules ont ete traites par radiofrequence. La necrose complete etait objectivee pour 05 nodules sur 06 traites soit 83%. La persistance d'un residu tumoral a ete observe dans 01 cas soit 17%. Deux deces etaient survenus a 08 et 09 mois. La survie sans recidive a 01 an etait de 100%.Conclusion : La prise en charge par radiofrequence percutanee de l'hepatocarcinome constitue une alternative efficace alliant innocuite; facilite et disponibilite

Aspects radiographiques des fractures traumatiques du coude de l'enfant

Introduction. Les observations cliniques semblaient indiquer que les fractures du coude qui sont des solutions de continuite osseuse concernant la palette humerale; l'olecrane et la tete radiale etaient frequentes et multimodales. Elles necessitaient des explorations radiographiques en complement du diagnostic clinique en meme temps qui permettaient la surveillance clinique de ces traumatismes. Les objectifs de ce travail etaient d'analyser les caracteristiques epidemiologiques et radiographiques des differents types de fractures du coude de l'enfant et de determiner l'existence de specificites eventuelles. Population et methodes. Il s'est agi d'une etude retrospective a visee descriptive sur une periode de 5 ans de patients adresses par le service de chirurgie pediatrique du CHU de Treichville qui presentaient une fracture du coude et qui avaient beneficie d'une radiographie standard de face et de profil avant et apres le traitement. Les examens ont ete realises sur un appareil analogique de marque APELEM Excel 2TS R (Nimes;France). Resultats. L'age moyen des patients etait de 6;35 ans avec 63;4 de sujets masculins. Le traumatisme etait survenu au decours d'une activite sportive dans 39;4 des cas. Le cote gauche etait atteint dans 60;6 des cas. Les lesions observees a la radiographie standard etaient des fractures supra-condyliennes (50;7); un refoulement des clartes graisseuses (73;2). Les lesions associees etaient craniennes (8;5). Nos patients ont beneficie d'un traitement orthopedique dans 63;4 et d'une chirurgie par embrochage dans 31. Le controle a 4 semaines indiquait que 95;1 des fractures etaient reduites et consolidees. Conclusion. Les fractures du coude de l'enfant etaient frequentes et graves. La radiographie standard a represente le support diagnostic de premiere intention et a permis une prise en charge adequate et une surveillance post therapeutique rendant ainsi le pronostic fonctionnel favorable

Apport de l'echographie mode B dans le diagnostic de decollement de la retine

Objectifs Preciser les aspects epidemiocliniques puis repertorier les aspects echographiques des decollements retiniens. Patients et methode. 65 patients ont beneficie d'une echographie oculaire avec une sonde lineaire de haute frequence de 12 Mhz sur une duree 18 mois. Resultats. La moyenne d'age etait de 26 ans avec des extremes de2 et90 ans et une predominance masculine (46 hommes pour 19 femmes); soit un sexe ratio de 2 hommes pour une femme. Les motifs de consultation etaient domines par le traumatisme et la cataracte. L'echographie a revele 37 decollements retiniens (DR) de l'oil droit avec 25 decollements totaux et 12 decollements partiels. Par contre 38 DR etaient localises au niveau de l'oil gauche (27 total et 11 partiel). 64;62 de patients presentaient un decollement retinien total et 27;69 pour decollement retinien partiel. Les pathologies associees au decollement etaient dominee par la cataracte et l'hemorragie intra-vitreenne. Conclusion. L'echographie oculaire est un examen essentiel dans le diagnostic du decollement retinien. C'est un examen simple a realiser permettant de deceler les pathologies associees

Apport de l'echographie mode B dans le diagnostic de decollement de la retine

Objectifs Preciser les aspects epidemiocliniques puis repertorier les aspects echographiques des decollements retiniens. Patients et methode. 65 patients ont beneficie d'une echographie oculaire avec une sonde lineaire de haute frequence de 12 Mhz sur une dure 18 mois.Resultats. La moyenne d'age etait de 26 ans avec des extremes de 2 et 90 ans et une predominance masculine (46 hommes pour 19 femmes); soit un sexe ratio de 2 hommes pour une femme. Les motifs de consultation etaient domines par le traumatisme et la cataracte. L'echographie a revele 37 decollements retiniens (DR) de l'oil droit avec 25 decollements totaux et 12 decollements partiels. Par contre 38 DR etaient localises au niveau de l'oil gauche (27 total et 11 partiel). 64;62% de patients presentaient un decollement retinien total et 27;69% pour decollement retinien partiel. Les pathologies associees au decollement etaient dominee par la cataracte et l'hemorragie intra-vitreenne. Conclusion. L'echographie oculaire est un examen essentiel dans le diagnostic du decollement retinien. C'est un examen simple a realiser permettant de deceler les pathologies associees

[Clinical-epidemiological profile of severe cutaneous drug reactions in children in Abidjan (Côte d'Ivoire)]. / Profil épidémio-clinique des toxidermies bulleuses chez l'enfant à Abidjan (Côte d'Ivoire).

Severe cutaneous drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life threatening in adults. They seem to be less common in children. The purpose of this study was to describe the epidemiological, clinical and etiological profile of these drug reactions in African child. It was about a retrospective study carried on for 10 years at the Dermatology center of University Hospital of Treichville, Abidjan (Cote d'Ivoire).Were included all children aged 0-15 years hospitalized for severe cutaneous drug reaction. They represented 14.1% (27 cases) with an estimated hospital rate of 0.01%. The sex ratio (M/F) was 1.2. The mean age was 10.3 years. 19 children were suffering from SJS (63%) and 9 children (33.3%) from TEN. Sulfonamides were the most commonly used drugs with sulfadoxin-pyrimethamin (25.9%), used for malariae, and cotrimoxazole (22.2%). Self-medication was practiced by 70.4% of parents. The average time to onset of lesions from drug intake was 8.2 days. Only one child was HIV infected. Three children affected by TEN (11.1%) died.

Occurrence of natural Anopheles arabiensis swarms in an urban area of Bobo-Dioulasso City, Burkina Faso, West Africa.

The swarming behaviour of natural populations of Anopheles arabiensis was investigated by conducting transect surveys on 10 consecutive days, around dusk, from March to April and from September to October 2012 in Dioulassoba, a district of Bobo-Dioulasso city in Burkina Faso (West Africa). Swarms were observed outside, around identified larval breeding sites on the banks of the Houet River, as well as in the open-air courtyards found at the centre of many homes in the region. Swarms were found to occur in open sunlit spaces, mostly located above physical or visual cues somehow visually distinct from the surrounding area. Overall 67 and 78 swarms were observed, respectively, during the dry season (March-April) and the rainy season (September-October) of 2012, between 1.5m and 4.5m above the ground at their centre. 964 mosquitoes were collected and analysed from dry season swarms, of which most were male, and all were An. arabiensis, as were the few resting mosquitoes collected indoors. Larvae collected from breeding sites found on the banks of the Houet River mostly consisted of An. arabiensis and only a minority of Anopheles coluzzii (formerly identified as An. gambiae M form). Of 1694 mosquitoes analysed from 78 swarms in the rainy season collections, a few An. gambiae (formerly known as An. gambiae S form) males were identified, and the remainders were An. arabiensis. The majority of larvae collected during the wet season from the same breeding sites were identified as An. arabiensis followed by An. coluzzii and An. gambiae. The same pattern of species composition was observed in resting mosquitoes, though the proportion of An. arabiensis was less overwhelming. These data support the conclusion that An. arabiensis is the most prevalent species in this area, though the difference in species composition when using different population sampling techniques is noteworthy. Further studies are required for more detailed investigations of male dispersal, feeding behaviour and mating patterns in this urban setting.

Swarming behaviour in natural populations of Anopheles gambiae and An. coluzzii: review of 4 years survey in rural areas of sympatry, Burkina Faso (West Africa).

The swarming behaviour of natural populations of Anopheles gambiae and An. coluzzii (formerly known as An. gambiae S and M forms, respectively) were investigated through longitudinal surveys conducted between July 2006 and October 2009 in two rural areas of south-western Burkina Faso where these forms are sympatric. In both sites, the majority of swarms were recorded above visual markers localised among houses. In Soumousso, a wooded area of savannah, 108 pairs caught in copula from 205 swarms were sampled; in VK7, a rice growing area, 491 couples from 250 swarms were sampled. If segregated swarms were the norm in both sites, many visual markers were shared by the two forms of An. gambiae. Furthermore, mixed swarms were collected annually in frequencies varying from one site to another, though no mixed inseminations were recorded, corroborating the low hybrid rate previously reported in the field. The occurrence of inter-specific mate-recognition mechanisms, which allow individuals to avoid hybridisation, is discussed.

[Bifocal Buruli ulcer: multiple cephalic lesions after initiation of medical treatment]. / Ulcère de Buruli à début bifocal: multiples lésions céphaliques après instauration du traitement médical.

BACKGROUND: Buruli ulcer (BU) denotes a cutaneous infection by Mycobacterium ulcerans endemic in certain tropical and subtropical regions. Treatment may be either medical and surgical or else purely medical for early lesions. The literature contains reports of several cases of transient aggravation of BU following initiation of medical treatment. We report a case observed in the Ivory Coast, one of the areas with the highest prevalence of BU worldwide. The distinguishing features of our case are the early onset of this paradoxical reaction and the multiple cephalic site of lesions. PATIENTS AND METHODS: A 4-year-old child with no prior medical history was referred for two painless ulcerative cutaneous nodules. Incubation of samples from the edges of these lesions revealed the presence of acid-alcohol resistant bacilli (AARB), which were shown by PCR to be M. ulcerans, the causative agent in BU. Treatment consisted of levofloxacin (100mg/d) and rifampicin (150mg/d) for 8weeks. After 7days of medical treatment, seven painless nodules appeared on the patient's scalp. Further PCR for these lesions confirmed the presence of M. ulcerans. The same medical therapy was maintained and after 54days of treatment, all lesions had been healed. DISCUSSION: The originality of this case rests on two features: the bifocal aspect of the lesions, which is uncommon, and the early development of cephalic predominance that occurred after the start of drug treatment. While cases of lesions secondary to initiation of medical therapy have already been described, such lesions generally occurred after at least 2months of treatment and did not involve the head.

Assortative mating in mixed swarms of the mosquito Anopheles gambiae s.s. M and S molecular forms, in Burkina Faso, West Africa.

The molecular form composition of Anopheles gambiae Giles s.s. (Diptera: Culicidae) mating swarms and the associated mating pairs (copulae) were investigated during two rainy seasons (July to October, 2005 and July to November, 2006) in the villages of Soumousso and Vallée du Kou (VK7). Although the habitats of these villages differ markedly, sympatric populations of M and S molecular forms of An. gambiae s.s. occur in both places periodically. The main aim was to assess the degree to which these molecular forms mate assortatively. In Soumousso, a wooded savannah habitat, the majority of swarm samples consisted of only S-form males (21/28), although a few M-form males were found in mixed M- and S-form swarms. In VK7, a rice growing area, the majority of swarm samples consisted of only M-form males (38/62), until October and November 2006, when there were nearly as many mixed-form as single-form swarms. Overall, ∼60% of M- and S-form swarms were temporally or spatially segregated; the two forms were effectively prevented from encountering each other. Of the remaining 40% of swarms, however, only about half were single-form and the rest were mixed-form. Of the 33 copulae collected from mixed-form swarms, only four were mixed-form pairs, significantly fewer than expected by random pairing between forms (χ(2) = 10.34, d.f. = 2, P < 0.01). Finally, all specimens of inseminated females were of the same form as the sperm contained within their spermatheca (n = 91), even for the four mixed-form copulae. These findings indicate that assortative mating occurs within mixed-form swarms, mediated most probably by close-range mate recognition cues.

Maladie de kaposi developpee sur greffon de peau chez un patient infecte par le VIH a Abidjan

Introduction : La maladie de Kaposi est une proliferation maligne multifocale de cellules endotheliales. 95 des cas observes a Abidjan; sont associes au SIDA. Observation : Nous rapportons chez un malade atteint de SIDA un cas d' erysipele de jambe complique de fasciite necrosante; sur laquelle se sont developpees des lesions de maladie de Kaposi a la phase de cicatrisation. Conclusion Devant une lesion angiomateuse chez un malade seropositif presentant une grosse jambe; il faudrait evoquer une maladie de Kaposi