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1.
Mali Med ; 36(1): 66-69, 2021.
Artigo em Francês | MEDLINE | ID: mdl-37973568

RESUMO

OBJECTIF: The aim of this study was to describe the results of radiochemotherapy in patients after transurethral resection of muscle invasive bladder tumors. MATERIAL AND METHODS: A retrospective study from May 2014 to May 2016 in the radiotherapy department of the Mali Hospital. Have been included, all patients with bladder cancer infiltrating the muscle. Secondary cancers of the bladder and metastatic forms have been excluded from our study. Transurethral resection of bladder was performed. Neoadjuvant chemotherapy with paclitaxel- carboplatin was administered every three weeks in all patients, then external phototherapy 6 MV at a dose of 66 Gy due to 2 Gy of 5 sessions per week 6MV photon of external beam radiotherapy at a dose of 66 Gy due to 2 Gy of 5 sessions per week associated with concomitant cisplatin at dose of 40mg / m2 / week. RESULTS: Eight patients were included in ourstudy. The average age of 53.75 ± 14.84 years. The male sex was predominant 87.5% (n = 7). The history of chronic smoking wasfound in four patients. The main carcinogenic risk factor identified in our patients was urogenital bilharzia (6 cases / 8).The histological type found was urothelial carcinomain 12.5% (n = 1) and invasive squamous cell carcinomain 87.5% (n = 7). Transurethral resection of the tumor was performed in 62.5% (n = 5). Endoscopic biopsy was performed in 37.5% (n = 3). The tumor was classified pT2N0M0 in 50% (n = 4), pT3aN0M0 in 37.5% (n = 3) and pT3bN0M0 in 12.5% (n = 1). Neoadjuvant chemotherapy with paclitaxel - carboplatin every three weeks was administered to all patients. The results of radiochemotherapy (see Table: evolution). CONCLUSION: Concomitant radiochemotherapy is a conservative curative treatment that can be proposed as a replacement for cystectomy, for non-metastatic infiltrating tumors after the most complete endoscopic resection.


OBJECTIF: Le but de cette étude était de décrire les résultats d'une radiochimiothérapie chez les patients après résection transurétrale des tumeurs de vessie infiltrant le muscle. MATÉRIEL ET MÉTHODES: Une étude rétrospective allant de mai 2014 à mai 2016 au service de radiothérapie de l'hôpital du Mali. Ont été inclus, tous les patients présentant un cancer de vessie infiltrant le muscle. Les cancers secondaires de la vessie ainsi que les formes métastatiques ont été exclus de notre étude. La résection transurétrale de vessie a été réalisée. La chimiothérapie néoadjuvante à base de paclitaxel ­ carboplatine a été administrée toutes les trois semaines. La radiothérapie externe au photon 6MV à la dose de 66 Gy en raison de 2 Gy de 5 séances par semaine associée à la chimiothérapie concomitante à base de cisplatine (CDDP) 40mg/m2/semaine a été réalisée. RÉSULTATS: Au total huit patients ont été inclus dans notre étude. L'âge moyen de 53,75±14,84 ans. Le sexe masculin était prédominant 87.5% (n=7). L'antécédent de tabagisme chronique était retrouvé chez quatre patients. Le principal facteur de risque cancérigène identifié chez nos patients était la bilharziose urogénitale (6cas/8). Le type histologique retrouvé était le carcinome urothelial dans 12.5% (n=1) et le carcinome épidermoïde infiltrant dans 87.5% (n=7). La résection transurétrale de la tumeur a été réalisée dans 62.5% (n=5). La biopsie par voie endoscopique été réalisée dans 37.5% (n=3). La tumeur été classée pT2N0M0 dans 50% (n= 4), pT3aN0M0 dans 37.5% (n=3) et pT3bN0M0 dans 12.5% (n= 1). La chimiothérapie néoadjuvante à base de paclitaxel ­ carboplatine chaque trois semaines a été administrée chez tous les malades.Les résultats de la radiochimiothérapie (cf. Tableau: évolution). CONCLUSION: La radiochimiothérapie concomitante est un traitement curatif conservateur qui peut être proposée en remplacement à la cystectomie pour les tumeurs infiltrantes non métastatiques après une résection endoscopique la plus complète possible.

2.
Mali Med ; 34(3): 39-43, 2019.
Artigo em Francês | MEDLINE | ID: mdl-35897220

RESUMO

PURPOSE: Delays to access to radiotherapy are long in our context. The purpose of this study was to analyze the effect of neoadjuvant chemotherapy to concomitant chemoradiotherapy in locally advanced cervical cancers. PATIENTS AND METHODS: We conducted a retrospective study from April 2014 to April 2016 at the radiotherapy center of "Hopital du Mali" in Bamako, Mali. Patients were allocated according to age, histological type, tumor size and the 2002 classification of the FIGO. Experimental protocol was the administration of a neoadjuvante chemotherapy with association of Paclitaxel 175mg/m2 + Carboplatine AUC 5 every 3 weeks and radiothérapy cure with avec linac 6 MV at 70 Gy due to 5 sessions of 2 Gy per week associated with a concomitant chemotherapy with cisplatin at 40 mg/m2/week. The clinical response was assessed at the end of neoadjuvant chemotherapy and of concomitant chemoradiotherapy. RESULTS: Thirty patients were included in the study. The mean age was 53.63 ± 8.9 years. The mean size of the tumor was 5.17 cm (2 to 7 cm). According to the 2002 classification of the FIGO stages IIB were 33% (n = 10); IIIB were 57% (n = 17) and IVA were 10% (n = 3). Clinical evaluation at the end of neoadjuvant chemotherapy found: complete response 17 % (n = 5), partial response 10% (n = 3) and stable disease 73 % (n = 22). Evaluation at the end of the concomitant chemoradiotherapy had found the complete response in 90% (n = 27) and stable disease in 10% (n = 3). CONCLUSION: Neoadjuvant chemotherapy to concomitant chemoradiotherapy in locally advanced cervical cancer allows stabilization of the tumor and improves local control. Due to long delays to access to radiotherapy treatment in our context; neoadjuvant chemotherapy is an alternative to stabilize the disease and prevent distant metastasis from locally advanced cervical cancers.


OBJECTIF: Les délais d'attente pour accéder à la radiothérapie sont longs dans note contexte. L'objet de cette étude était d'analyser le résultat de la chimiothérapie néo adjuvante à la radiothérapie dans les cancers localement avancés du col utérin. PATIENTS ET MÉTHODES: Nous avons réalisé une étude rétrospective allant d'avril 2014 à avril 2016 au centre de radiothérapie de l'hôpital du Mali. Les patients ont été regroupés selon l'âge, le type histologique, la taille de la tumeur, la classification de la FIGO 2002. Le schéma thérapeutique était une chimiothérapie néo adjuvante associant Paclitaxel 175 mg/m2 et Carboplatine AUC 5 toutes les 3 semaines suivie d'une radiothérapie avec linac 6 MV à la dose de 70 Gy en raison de 5 séances de 2 Gy par semaine faite concomitamment à une chimiothérapie avec du cisplatine à la dose de 40 mg/m2/semaine. La réponse clinique était évaluée à la fin de la chimiothérapie néoadjuvante et de la radiochimiothérapie concomitante. RÉSULTATS: Trente patientes ont été incluses dans l'étude. L'âge moyen était de 53.63 ± 8.9 ans. La taille moyenne de la tumeur était de 5,17 cm (2 à 7 cm). Selon la classification FIGO 2002, 10 (33%) étaient en stade IIB distal, 17 (57%) étaient en stade IIIB et 3 (10%) en stade IVA. L'évaluation clinique à la fin de la chimiothérapie néo adjuvante avait retrouvé 17 % de réponses complètes (n=5), 10% de réponses partielles (n=3) 73 % d'évolutions stables (n=22). L'évaluation à la fin de la radiochimiothérapie concomitante avait trouvé une réponse complète chez 27 patientes (90%) et une maladie stable chez 3 (10%). CONCLUSION: La chimiothérapie néo adjuvante à la chimioradiothérapie concomitante dans les cancers localement avancés du col utérin permet la stabilisation de la tumeur et améliore le control local. En raison des délais d'attente longs pour accéder à la radiothérapie, la chimiothérapie néo adjuvante est une alternative pour stabiliser la maladie et réduire le risque de métastases à distance des cancers du col utérin localement avancés.

3.
Mali méd. (En ligne) ; 34(3): 39-43, 2019. ilus
Artigo em Francês | AIM (África) | ID: biblio-1265751

RESUMO

Les délais d'attente pour accéder à la radiothérapie sont longs dans note contexte. L'objet de cette étude était d'analyser le résultat de la chimiothérapie néo adjuvante à la radiothérapie dans les cancers localement avancés du col utérin. Patients et méthodes: Nous avons réalisé une étude rétrospective allant d'avril 2014 à avril 2016 au centre de radiothérapie de l'hôpital du Mali. Les patients ont été regroupés selon l'âge, le type histologique, la taille de la tumeur, la classification de la FIGO 2002. Le schéma thérapeutique était une chimiothérapie néo adjuvante associant Paclitaxel 175 mg/m2 et Carboplatine AUC 5 toutes les 3 semaines suivie d'une radiothérapie avec linac 6 MV à la dose de 70 Gy en raison de 5 séances de 2 Gy par semaine faite concomitamment à une chimiothérapie avec du cisplatine à la dose de 40 mg/m2/semaine. La réponse clinique était évaluée à la fin de la chimiothérapie néoadjuvante et de la radiochimiothérapie concomitante. Résultats : Trente patientes ont été incluses dans l'étude. L'âge moyen était de 53.63 ± 8.9 ans. La taille moyenne de la tumeur était de 5,17 cm (2 à 7 cm). Selon la classification FIGO 2002, 10 (33%) étaient en stade IIB distal, 17 (57%) étaient en stade IIIB et 3 (10%) en stade IVA. L'évaluation clinique à la fin de la chimiothérapie néo adjuvante avait retrouvé 17 % de réponses complètes (n=5), 10% de réponses partielles (n=3) 73 % d'évolutions stables (n=22). L'évaluation à la fin de laradiochimiothérapie concomitante avait trouvé une réponse complète chez 27 patientes (90%) et une maladie stable chez 3 (10%). Conclusion - La chimiothérapie néo adjuvante à la chimioradiothérapie concomitante dans les cancers localement avancés du col utérin permet la stabilisation de la tumeur et améliore le control local. En raison des délais d'attente longs pour accéder à la radiothérapie, la chimiothérapie néo adjuvante est une alternative pour stabiliser la maladie et réduire le risque de métastases à distance des cancers du col utérin localement avancés


Assuntos
Quimiorradioterapia , Mali , Neoplasias do Colo do Útero
4.
Med. Afr. noire (En ligne) ; 66(7): 363-369, 2019.
Artigo em Francês | AIM (África) | ID: biblio-1266340

RESUMO

Introduction : La sécurité transfusionnelle constitue un défi majeur dans les pays en développement. La sélection médicale est un élément essentiel dans la stratégie visant à réduire la transmission d'agents infectieux Mali. Dans ce travail nous avons évalué l'outil utilisé pour le screening pré-don dans l'unité de banque de sang de l'hôpital du Mali. Matériel et Méthodes : Il s'agissait d'une étude prospective du 30 mars 2016 au 14 février 2017 incluant tous les candidats au don de sang. Après la sélection médicale, une qualification biologique a été réalisée au niveau du Centre National de Transfusion Sanguine notamment pour les 4 infections transmissibles obligatoires de l'OMS (VHB, VHC, VIH et Syphilis). Résultats : Au total, 726 candidats au don ont été inclus. La moyenne d'âge était de 30,72 ± 8,8 ans, compris entre 17 et 60 ans. Le sex-ratio H/F était : 8,48. Il s'agissait dans 83,5% des cas d'un don de compensation, 67% étaient à leur premier don. La sélection médicale a permis d'écarter 108 candidats pour des raisons diverses. Sur les 618 candidats retenus, 79 soit 12,8% des PSL n'étaient pas qualifiés pour la distribution pour VIH (0,3%), VHB (10,7%), VHC (1,8%), syphilis (0,3%) et co-infection VHB+VHC (0,3%). Conclusion : Cette étude nous a permis d'identifier quelques insuffisances de l'outil. Nous concluons que cet outil utilisé pour la sélection médicale doit être amélioré


Assuntos
Doadores de Sangue , Segurança do Sangue , Países em Desenvolvimento , Mali
5.
Tese em Francês | AIM (África) | ID: biblio-1277423

RESUMO

Nous avons realise une etude prospective sur une periode d`une annee (janvier 2003-Decembre 2003) dans le service de reanimation de l`hopital du point G sur le paludisme grave et complique. Le but de cette etude a ete de determiner la frequence et les modalites de prise en charge du paludisme grave et complique : Interet de l`Optimal IT dans le diagnostic du paludisme. Nous avons inclus au total 91 cas de Paludisme grave; la tranche d`age la plus representee se situait entre 20 et 50 ans; l`automedication a ete lepremier recours en cas de paludisme; la letalite hospitaliere du neuropaludisme etait de 21.4. Le coma sur fond de detresse respiratoire associe a des crises convulsives etait le tableau clinique le plus frequent ce qui a necessite en plus de l`oxygenotherapie; une intubation tracheale chez certains patients et la mise en place d`une canule de Guedel


Assuntos
Malária/complicações , Malária/diagnóstico
6.
J Radiol ; 79(7): 683-6, 1998 Jul.
Artigo em Francês | MEDLINE | ID: mdl-9757296

RESUMO

We report a case of a rare and particular cause of abdominal calcifications represented by the lithopedion. We describe different radiologic appearances observed by: abdominal plain film, echography and CT. It appeared to us that abdominal plain film alone is sufficient for diagnosis and undertaking surgery. Echography and CT are helpful, especially for complementary evaluation.


Assuntos
Calcinose/etiologia , Morte Fetal/diagnóstico , Gravidez Abdominal/diagnóstico , Idoso , Calcinose/diagnóstico por imagem , Calcinose/cirurgia , Feminino , Morte Fetal/diagnóstico por imagem , Morte Fetal/cirurgia , Humanos , Gravidez , Gravidez Abdominal/diagnóstico por imagem , Gravidez Abdominal/cirurgia , Radiografia Abdominal , Fatores de Tempo , Tomografia Computadorizada por Raios X , Ultrassonografia
7.
Sante ; 7(1): 25-31, 1997.
Artigo em Francês | MEDLINE | ID: mdl-9172873

RESUMO

The abdomen in patients with acquired immunodeficiency syndrome (AIDS) is subject to various damage. In AIDS patients, manifestations in the retroperitoneal region, including apparent changes in the pancreas, kidney and lymph nodes, have been well described in the radiological literature. However, abnormalities of the vessels and perivascular spaces have not been well investigated in this syndrome. We performed abdominal sonography in 10 patients who were seropositive for HIV. They had no history of known risk factors such as drug abuse or homosexuality. Also, 4 healthy male controls were examined for comparison. Our aim was to demonstrate and to characterize the pathological changes of the retroperitoneal vessels and perivascular spaces from sonographic observations. The sonographic evaluation included determination of the morphologic and dynamic aspects of the aorta, vena cava and superior mesenteric vessels. The echostructure of the perivascular spaces was analyzed. In this prospective and preliminary study, we have not considered the presence of an AIDS condition. We have precisely analyzed the upper umbilical areas. In all cases, there were supposed to be the same landmarks. The sonographic scans were obtained through the left renal and mesenteric vessel areas, essentially through axial scans. In all 10 patients, sonography showed at least two abnormalities. Three patients had abnormal echostructural changes in all the sites. The images showed echostructural disorganization with poor definition and "fuzzy" and "dirty" aspects of the retroperitoneal vessels and perivascular spaces. The aorta was normal in 2 patients and abnormal in 8 patients with diminished hyperechography and regularity of the aortal wall. The aortic diameter was smaller than 1.5 cm in 7 cases, with a significant attenuation of the beating of the aorta. Despite these abnormalities, the aorta had a normal left paramedian position ahead of the rachis. The inferior vena cava was normal in 1 case and abnormal in 9 cases with diminished hyperechography and regularity of the wall. The vena cava position was normal in 4 cases, displaced in 6, and laminated in 3. The superior mesenteric vessels were abnormal in 8 cases, with poorly defined aims in 6, an indefinite position in 2, and spreading in 2. Adenopathy was present in 6 patients, multiple in 5 and singular in 1 case. A retrocaval location was always observed. A perivascular infiltration and thickening was noted which was diffuse in 6 cases and micronodular in 1 case. From our observations, we conclude that these echostructural changes could be related to AIDS. However, further studies are necessary to confirm these observations and to determine if this sonographic pattern may be seen during the course of the disease. This is the first study to our knowledge which stressed the echostructural changes of the retroperitoneal vessels and perivascular spaces in patients with AIDS.


Assuntos
Abdome/diagnóstico por imagem , Infecções por HIV/diagnóstico por imagem , Soropositividade para HIV/diagnóstico por imagem , Síndrome da Imunodeficiência Adquirida/diagnóstico por imagem , Adulto , Aorta Abdominal/diagnóstico por imagem , Feminino , Humanos , Linfonodos/diagnóstico por imagem , Masculino , Artéria Mesentérica Superior/diagnóstico por imagem , Veias Mesentéricas/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Prospectivos , Artéria Renal/diagnóstico por imagem , Veias Renais/diagnóstico por imagem , Espaço Retroperitoneal , Ultrassonografia , Umbigo/diagnóstico por imagem , Veia Cava Inferior/diagnóstico por imagem
8.
Sante ; 6(4): 245-8, 1996.
Artigo em Francês | MEDLINE | ID: mdl-9026323

RESUMO

Subcutaneous and soft tissue involvement is frequent in AIDS patients. Although the relevant clinical characteristics have been extensively described in the literature, there has been little work on the radiological features. We therefore report three cases of AIDS with subcutaneous and soft tissue involvement: two cases of pyomyositis and one case of non-Hodgkin's lymphoma. All three were black African men and were aged 22, 28 and 41 years. They were diagnosed as suffering from AIDS and were HIV1 and HIV2 positive. Diagnosis was established using needle puncture and histological (lymphoma) and bacteriological (pyomyositis) examination. We report ultrasound scan findings. The features of the pyomyositis differed from those usually observed in immunocompetent patients. The lymphoma nodules were similar to those described in the literature. They were hypoechoic and homogeneous, with no necrotic center. We believe that subcutaneous and soft tissue infectious involvement, for example pyomyositis, is more frequent in tropical regions than tumors (Kaposi's sarcoma, lymphoma) which are more frequent in Europe. This soft tissue involvement can be considered to be part of the particular picture which is "tropical AIDS".


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico por imagem , Linfoma Relacionado a AIDS/diagnóstico por imagem , Linfoma não Hodgkin/diagnóstico por imagem , Miosite/diagnóstico por imagem , Infecções dos Tecidos Moles/diagnóstico por imagem , Infecções Oportunistas Relacionadas com a AIDS/patologia , Adulto , Biópsia por Agulha , Côte d'Ivoire , Soropositividade para HIV , HIV-1 , HIV-2 , Humanos , Linfoma Relacionado a AIDS/patologia , Linfoma não Hodgkin/patologia , Masculino , Miosite/microbiologia , Miosite/patologia , Infecções dos Tecidos Moles/patologia , Clima Tropical , Ultrassonografia
9.
Sante ; 6(3): 145-50, 1996.
Artigo em Francês | MEDLINE | ID: mdl-8764447

RESUMO

Echography was prospectively performed in 345 black African female patients with pelvic masses which had been clinically detected in some cases. The women were between 11 and 65 years old. The aims of this study were to list the pelvic masses observed in black. African women, to record any potentially distinguishing features and to evaluate the sensitivity and the specificity of echography as applied here. A total of 477 masses were listed. Ovarian masses were the most frequent (56.66%) followed by uterine masses (31.45%). Most masses were benign. We observed only two cases of ovarian cancer. The sensitivity was 100% and the specificity was 97.69%. Eleven cases (2.3%) of the ultrasound diagnoses did not correspond with the final diagnoses. As for distinguishing aspects, these patients were younger than European patients-this was particularly true for patients with fibroid masses (a range of 31 to 40 years compared to 40 to 50 years). Genetic factors in these patients could explain the high rate and early appearance of fibroids. Because the diagnosis of vaginal masses is well established by clinical examination rather than by echography, this lesion was rarely observed. The most frequent clinical complaint was pelvic pain (36.94%), followed by pelvic mass impression (28.65%). We found high rates of both past histories of miscarriage and abortion (60.7%) and postabortion pelvic hematoma. The hematomas comprised 45.4% of the non-genital pelvic masses. Misdiagnosis of pyosalpinx was often a source of diagnostic error. Thus, to avoid false diagnoses of pyosalpinx in evaluating pelvic masses with a void in ultrasound, the possibility of an infectious episode should be evaluated by definitive questioning. Ultrasound examination is of value in evaluating the pelvic masses of women; however, this should be considered within the appropriate disease context.


Assuntos
População Negra , Doenças dos Genitais Femininos/diagnóstico por imagem , Doenças Uterinas/diagnóstico por imagem , Doenças Vaginais/diagnóstico por imagem , Aborto Induzido/efeitos adversos , Aborto Espontâneo/complicações , Adolescente , Adulto , Fatores Etários , Idoso , Infecções Bacterianas/diagnóstico por imagem , Criança , Côte d'Ivoire , Doenças das Tubas Uterinas/diagnóstico por imagem , Doenças das Tubas Uterinas/microbiologia , Feminino , Hematoma/complicações , Humanos , Leiomioma/diagnóstico por imagem , Leiomioma/genética , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico por imagem , Gravidez , Estudos Prospectivos , Sensibilidade e Especificidade , Ultrassonografia , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/genética , Neoplasias Vaginais/diagnóstico por imagem , Neoplasias Vaginais/genética
10.
Rev Pneumol Clin ; 52(6): 398-403, 1996.
Artigo em Francês | MEDLINE | ID: mdl-9033934

RESUMO

Both clinical and radiologic manifestations can have unusual figures in patients with acquired immunodeficiency syndrome (AIDS). Infectious involvement, as in particularly tuberculosis, may simulate a neoplasm, and vice versa. We report a case of a tubercular pleuresy followed 14 months later by a lung cancer in a patient infected with the human immunodeficiency virus (HIV). This observation pose the delicate diagnostic problem of a recurred endobronchial tuberculosis we describe the chest roentgenograms and the computed tomography-scans patterns. We give the place of both of them. We call attention to the valuable rôle of the endobronchial endoscopy in the differential diagnosis between a recurrence of the tuberculosis or a lung cancer. This case demonstrate quite well that thoracic complications in AIDS are multiple and can be variable in the course of the disease. That command a definite exploration for an appropriate diagnosis and treatment.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Adenocarcinoma/etiologia , Neoplasias Brônquicas/etiologia , HIV-1 , HIV-2 , Tuberculose Pleural/etiologia , Humanos , Masculino , Pessoa de Meia-Idade
11.
Publications Medicales Africaines ; 26(125): 30-36, 1993.
Artigo em Francês | AIM (África) | ID: biblio-1268871

RESUMO

A partir d'une etude prospective portant sur 7 ans; 2000 cas de derangements internes du genou ont ete analyses. Les lesions sont frequentes chez les sujets jeunes de sexe masculin (87 pour cent) avec pour cause essentielle les traumatismes surtout lors de la pratique du football. Les resultats arthrographiques revelent l'atteinte frequente des menisques surtout avec une predominance des fissurations


Assuntos
Artrografia/métodos , Traumatismos em Atletas , Futebol Americano , Traumatismos do Joelho/diagnóstico por imagem , Menisco
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